DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab7 and RAB10

DIOPT Version :9

Sequence 1:	NP_001247276.1	Gene:	Rab7 / 42841	FlyBaseID:	FBgn0015795	Length:	207	Species:	Drosophila melanogaster
Sequence 2:	NP_057215.3	Gene:	RAB10 / 10890	HGNCID:	9759	Length:	200	Species:	Homo sapiens

Alignment Length:	170	Identity:	64/170 - (37%)
Similarity:	105/170 - (61%)	Gaps:	10/170 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLKVIILGDSSVGKTSLMNQYVNKRFSNQYKATIGADFCTKEVVVNDRVVTMQIWDTAGQERFQS 72
            |.|::::|||.||||.::.::.:..|:..:.:|||.||..|.|.:..:.:.:|||||||||||.:
Human     9 LFKLLLIGDSGVGKTCVLFRFSDDAFNTTFISTIGIDFKIKTVELQGKKIKLQIWDTAGQERFHT 73

  Fly    73 LGVAFYRGADCCVLVYDVTAPNSFKNLDSWR---DEFLIQASPRDPDHFPFVVLGNKVDLDNRQV 134
            :..::||||...:||||:|...||:|:..|.   ||...:...|       ::||||.|:|:::|
Human    74 ITTSYYRGAMGIMLVYDITNGKSFENISKWLRNIDEHANEDVER-------MLLGNKCDMDDKRV 131

  Fly   135 STRRAQQWCQSKNDIPYYETSAKEGINVEMAFQVIAKNAL 174
            ..:...:....::.|.::|||||..||:|.||..:|::.|
Human   132 VPKGKGEQIAREHGIRFFETSAKANINIEKAFLTLAEDIL 171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab7	NP_001247276.1	Rab7	9..179	CDD:206655	63/169 (37%)
Rab7	NP_001247276.1	RAB	9..174	CDD:197555	62/167 (37%)
RAB10	NP_057215.3	Rab8_Rab10_Rab13_like	7..173	CDD:206659	64/170 (38%)
RAB10	NP_057215.3	Effector region. /evidence=ECO:0000250	38..46		3/7 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910