DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13604 and UBASH3B

DIOPT Version :9

Sequence 1:	NP_001262894.1	Gene:	CG13604 / 42840	FlyBaseID:	FBgn0039137	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	XP_005271769.1	Gene:	UBASH3B / 84959	HGNCID:	29884	Length:	677	Species:	Homo sapiens

Alignment Length:	714	Identity:	246/714 - (34%)
Similarity:	351/714 - (49%)	Gaps:	133/714 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 EKALASTGNRGVQIASDWLLAHVNDGTLDECAPREYIIYACPTGPFLQQLEEFWAKSRQMCGWNG 103
            :|||||||.|.||.|.|||.:||.|..||:..||||::|..||||..|:|.:||.:|:|:||.|.
Human    83 QKALASTGGRSVQAACDWLFSHVGDPFLDDPLPREYVLYLRPTGPLAQKLSDFWQQSKQICGKNK 147

  Fly   104 AHNYVPHITLVSFFKAPDECSLQLSKALKQVVDMTGALLDRPLKLEPYMSQNFMGFFVAEEDANY 168
            |||..|||||..||...|.....|.:||:..|.........||.||.|.|.||:|.||.|:.|..
Human   148 AHNIFPHITLCQFFMCEDSKVDALGEALQTTVSRWKCKFSAPLPLELYTSSNFIGLFVKEDSAEV 212

  Fly   169 LKRLALQYVKEVSNSIISDTYEQLDAIVACFPWCGAVSSGTRCIPRSSRSISLEPHVKSLHLTLA 233
            ||:.|..:..|.:                                 |...:.:|||.|.||:|||
Human   213 LKKFAADFAAEAA---------------------------------SKTEVHVEPHKKQLHVTLA 244

  Fly   234 YQFPQAQFNALKALVETLDASCASNWELRLYSRDPRLATKQVQKVVYPHNPHETDELELRIGDYI 298
            |.|..:....|:.|.:.:|.....:|...::|||.|.|..:..:|:||:.|...|||||..||:|
Human   245 YHFQASHLPTLEKLAQNIDVKLGCDWVATIFSRDIRFANHETLQVIYPYTPQNDDELELVPGDFI 309

  Fly   299 YLNTEVVDSSSDGWAEGISWLTGSTGHLPVNYTERTAESDAWTLHRVVQLSKSVASSLTSAEDLD 363
            :::.....|:|:||..|.|..||.:|.||.||..:..|...|..|.    |.|:.:: :|:..|.
Human   310 FMSPMEQTSTSEGWIYGTSLTTGCSGLLPENYITKADECSTWIFHG----SYSILNT-SSSNSLT 369

  Fly   364 IVDGRSISTEPDDRQNTAHPDIIEGSSFEESEQSVEKYLRQTLKPCLELPSVQLLNSHNLTHQHN 428
            ..||                 ::|...:|      ::.|.:|
Human   370 FGDG-----------------VLERRPYE------DQGLGET----------------------- 388

  Fly   429 PNTPTIEITTNMSSSSTSMSKQPVDEILVEPPAAQPPRPDDTLSVHSDHSLHPGSLDASHAKNRK 493
              ||...|                         .||.:|   |.|:|    .||      .:.|.
Human   389 --TPLTII-------------------------CQPMQP---LRVNS----QPG------PQKRC 413

  Fly   494 IYIMRHGERVDFTFGT-WIPYCFDEFGNYMRKDLNMPKTLPRRKNSPEGWQNDSPLTNVGVYQAN 557
            :::.|||||:|..||. |:..|||..|.|:|.:||||.:||:|......::.|:|:|..|..||.
Human   414 LFVCRHGERMDVVFGKYWLSQCFDAKGRYIRTNLNMPHSLPQRSGGFRDYEKDAPITVFGCMQAR 478

  Fly   558 LIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEGLKLTGKQKIKLEPGLFEWMAWYP-SGVPDWL 621
            |:|:||||:...|||||||||.||:||..:.|:||:.....||::|||||||..|.. |.:|.|:
Human   479 LVGEALLESNTIIDHVYCSPSLRCVQTAHNILKGLQQENHLKIRVEPGLFEWTKWVAGSTLPAWI 543

  Fly   622 TKNELTEAKFDVDLDYEPVQPASELTARLKESTEQFYERNHDVILQLLEQTT---GNILVVAHAT 683
            ..:||..|...||..|.|..|.|:|.  :.||.:.:..|:..|..:::.:..   .|||:||||:
Human   544 PPSELAAANLSVDTTYRPHIPISKLV--VSESYDTYISRSFQVTKEIISECKSKGNNILIVAHAS 606

  Fly   684 TLDTCSRQLTGGVPRSTNELRQVIHKIPYCSLATVEQV--DGVWKLVEPECLPVTHSKNPRFEW 745
            :|:.|:.||.|..|:::.:..|::.||||....:.|::  .|:|:|.:|..||:||.....|.|
Human   607 SLEACTCQLQGLSPQNSKDFVQMVRKIPYLGFCSCEELGETGIWQLTDPPILPLTHGPTGGFNW 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13604	NP_001262894.1	UBA_UBS3B	23..60	CDD:270486	14/20 (70%)
		SH3_UBASH3	275..333	CDD:212725	25/57 (44%)
		His_Phos_1	494..728	CDD:278716	98/240 (41%)
UBASH3B	XP_005271769.1	UBA_like_SF	<83..104	CDD:304366	14/20 (70%)
		SH3_UBASH3B	284..345	CDD:212869	25/60 (42%)
		HP_PGM_like	414..626	CDD:132718	90/213 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149956
Domainoid	1	1.000	140	1.000	Domainoid score	I4757
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13152
Inparanoid	1	1.050	463	1.000	Inparanoid score	I1557
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45538
OrthoDB	1	1.010	-	-		D130139at33208
OrthoFinder	1	1.000	-	-		FOG0002396
OrthoInspector	1	1.000	-	-		otm41135
orthoMCL	1	0.900	-	-		OOG6_102745
Panther	1	1.100	-	-	LDO	PTHR16469
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3907
SonicParanoid	1	1.000	-	-		X1080
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800