DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13604 and ubash3bb

DIOPT Version :9

Sequence 1:	NP_001262894.1	Gene:	CG13604 / 42840	FlyBaseID:	FBgn0039137	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	NP_001122227.1	Gene:	ubash3bb / 569827	ZFINID:	ZDB-GENE-080724-6	Length:	642	Species:	Danio rerio

Alignment Length:	752	Identity:	264/752 - (35%)
Similarity:	365/752 - (48%)	Gaps:	138/752 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPPRKSQTPTRICISKQHLTPLQTLLQMGFPRHRAEKALASTGNRGVQIASDWLLAHVNDGTLDE 68
            :|.|..|..   |:|.:|.:.|..||.||||:.||.|||||||.|.||:|.|||.:|::|..||:
Zfish    12 IPRRLRQNS---CVSVKHGSNLDVLLSMGFPQQRALKALASTGGRSVQLACDWLFSHLDDPFLDD 73

  Fly    69 CAPREYIIYACPTGPFLQQLEEFWAKSRQMCGWNGAHNYVPHITLVSFFKAPDECSLQLSKALKQ 133
            ..||||::|..|:||...||..||.:||..||.|.|||..|||||..||..||...:.|.:||:.
Zfish    74 SLPREYVLYLRPSGPLQNQLSHFWQQSRFTCGKNKAHNIFPHITLCQFFMCPDSKLVALCEALQS 138

  Fly   134 VVDMTGALLDRPLKLEPYMSQNFMGFFVAEEDANYLKRLALQYVKEVSNSIISDTYEQLDAIVAC 198
            .|:........||.||.|.|.||:|.||.|:.|..||:.|..:..|.:..:
Zfish   139 SVNQWRGRFPSPLPLELYTSTNFIGLFVEEQVAETLKQFAADFAVEAAAKV-------------- 189

  Fly   199 FPWCGAVSSGTRCIPRSSRSISLEPHVKSLHLTLAYQFPQAQFNALKALVETLDASCASNWELRL 263
                               .:.:|||.|.|||||||.||...:::|:.|.:.::.....:|...|
Zfish   190 -------------------DVHVEPHKKQLHLTLAYHFPTNHYHSLEKLAKGIEVKLGCDWLAAL 235

  Fly   264 YSRDPRLATKQVQKVVYPHNPHETDELELRIGDYIYLNTEVVDSSSDGWAEGISWLTGSTGHLPV 328
            :|||.|.|..:..:|:||:.|...|||||..||||:.:|....|:|:||..|.|..||.:|.||.
Zfish   236 FSRDIRFANHETLRVMYPYTPQNDDELELVPGDYIFSSTLEQMSTSEGWVYGTSLGTGISGLLPE 300

  Fly   329 NYTERTAESDAWTLHRVVQLSKSVASSLTSAEDLDIVDGRSISTEPDD---RQNTAHPDIIEGSS 390
            ||.....|||.|..|.    |.|.                 ..|.|.:   ::..|...::....
Zfish   301 NYVSPADESDTWVFHG----SHSF-----------------FCTSPSEKGCKETKALDGLLNIRC 344

  Fly   391 FEESEQSVEKYLRQTLKPCLELPSVQLLNSHNLTHQHNPNTPTIEITTNMSSSSTSMSKQPVDEI 455
            ||.|.......|....:|      :|:|.| |:
Zfish   345 FENSRLGESAILSVICQP------MQVLRS-NI-------------------------------- 370

  Fly   456 LVEPPAAQPPRPDDTLSVHSDHSLHPGSLDASHAKNRKIYIMRHGERVDFTFGT-WIPYCFDEFG 519
                                          .|.|..|.:::.|||||:|..||. |:..|.|..|
Zfish   371 ------------------------------QSRAPKRTLFVCRHGERMDVVFGKHWLSQCSDSKG 405

  Fly   520 NYMRKDLNMPKTLPRRKNSPEGWQNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCSPSYRCIQT 584
            .|:|::||||..||.|..:...::.|:|:|.||..||.::|:||||:...||.||||||.||:||
Zfish   406 RYVRRNLNMPAALPARGATHRDYEMDAPITVVGSTQAKIVGEALLESNTSIDFVYCSPSLRCVQT 470

  Fly   585 CTSALEGLKLTGKQKIKLEPGLFEWMAWYP-SGVPDWLTKNELTEAKFDVDLDYEPVQPASELTA 648
            ....|.|::..|:..|::|||||||..|.. :.:|.|:...:|..|..:||..|.|..|.|:||
Zfish   471 AHEILRGMQQEGRLSIRVEPGLFEWTKWVSGTSLPAWIPPTDLAAANLNVDTTYRPHMPISKLT- 534

  Fly   649 RLKESTEQFYERNHDV---ILQLLEQTTGNILVVAHATTLDTCSRQLTGGVPRSTNELRQVIHKI 710
             :.|:.|.:..|::.|   ||...:....|||.|.||::|:.|:|||.|...:::.:..||:.||
Zfish   535 -VSEAYETYISRSNQVTKDILAYCKNKGKNILFVGHASSLEACTRQLQGLSSQNSKDFVQVVRKI 598

  Fly   711 PYCSL-ATVEQVD-GVWKLVEPECLPVTHSKNPRFEW 745
            ||..| |..||.| |:|:||:|..||:||..|..|.|
Zfish   599 PYLGLCACEEQGDSGIWQLVDPPILPLTHGPNHSFSW 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13604	NP_001262894.1	UBA_UBS3B	23..60	CDD:270486	23/36 (64%)
		SH3_UBASH3	275..333	CDD:212725	27/57 (47%)
		His_Phos_1	494..728	CDD:278716	100/240 (42%)
ubash3bb	NP_001122227.1	UBA_UBS3B	28..65	CDD:270486	23/36 (64%)
		SH3_UBASH3B	245..306	CDD:212869	27/60 (45%)
		HP_PGM_like	378..613	CDD:132718	98/236 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584105
Domainoid	1	1.000	139	1.000	Domainoid score	I4749
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13152
Inparanoid	1	1.050	469	1.000	Inparanoid score	I1487
OMA	1	1.010	-	-		QHG45538
OrthoDB	1	1.010	-	-		D130139at33208
OrthoFinder	1	1.000	-	-		FOG0002396
OrthoInspector	1	1.000	-	-		otm24640
orthoMCL	1	0.900	-	-		OOG6_102745
Panther	1	1.100	-	-	O	PTHR16469
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1080
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770