DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13604 and ubash3ba

DIOPT Version :9

Sequence 1:	NP_001262894.1	Gene:	CG13604 / 42840	FlyBaseID:	FBgn0039137	Length:	763	Species:	Drosophila melanogaster
Sequence 2:	XP_001923885.2	Gene:	ubash3ba / 558545	ZFINID:	ZDB-GENE-060526-172	Length:	643	Species:	Danio rerio

Alignment Length:	760	Identity:	261/760 - (34%)
Similarity:	365/760 - (48%)	Gaps:	148/760 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ATLPPR--KSQTPTRICISKQHLTPLQTLLQMGFPRHRAEKALASTGNRGVQIASDWLLAHVNDG 64
            |.:.||  :...|..:    :|...|..||.||||:.||.|||.|||.|.||.|.|||.:||:|.
Zfish     9 AKVAPRMQRQNRPATV----KHGNSLDVLLSMGFPKTRALKALVSTGGRNVQAACDWLFSHVDDP 69

  Fly    65 TLDECAPREYIIYACPTGPFLQQLEEFWAKSRQMCGWNGAHNYVPHITLVSFFKAPDECSLQLSK 129
            .||:..||||::|..|:||.|.||..||.:||..||.|.|||..|||||..||...|.....|.:
Zfish    70 FLDDPLPREYVLYLKPSGPLLNQLSNFWQQSRITCGKNKAHNIFPHITLCQFFMCADGKVDALGE 134

  Fly   130 ALKQVVDMTGALLDRPLKLEPYMSQNFMGFFVAEEDANYLKRLALQYVKEVSNSIISDTYEQLDA 194
            ||:.||.........||.||.|.|.||:|.||.|:.|..:|..|..:..|.:
Zfish   135 ALQTVVGNWKGRFPSPLPLEFYSSSNFIGLFVEEKVAEVIKSFAADFATEAA------------- 186

  Fly   195 IVACFPWCGAVSSGTRCIPRSSRSISLEPHVKSLHLTLAYQFPQAQFNALKALVETLDASCASNW 259
                                |...:.:|||.|.||:||||.|......:|:.|.:.:|.:...:|
Zfish   187 --------------------SKADVHVEPHKKQLHVTLAYHFQSNHLASLEKLAKGVDITLGCDW 231

  Fly   260 ELRLYSRDPRLATKQVQKVVYPHNPHETDELELRIGDYIYLNTEVVDSSSDGWAEGISWLTGSTG 324
            :..|.|||.|.|..:..:|:||:.|...|||||..||:|::::....::|:||..|.|..||.:|
Zfish   232 QTVLLSRDIRFANHETLRVMYPYVPQNDDELELVPGDFIFMSSIEQTTASEGWVYGTSMSTGLSG 296

  Fly   325 HLPVNYTERTAESDAWTLHRVVQLSKSVASSLTSAEDLDIVDGRSISTEPDDRQNT-------AH 382
            .||.||..|..|.|.|..|                .....::|    |.|.:.:..       .|
Zfish   297 LLPENYVNRADECDTWVSH----------------GSFSFLNG----TPPTNIRGAMGGLFLDQH 341

  Fly   383 PDIIEGSSFEESEQSVEKYLRQTLKPCLELPSVQLLNSHNLTHQHNPNTPTIEITTNMSSSSTSM 447
               ::|..|::                 .:|    |:|.||:
Zfish   342 ---LDGRLFDD-----------------PMP----LDSPNLS----------------------- 359

  Fly   448 SKQPVDEILVEPPAAQPPRPDDTLSVHSDHSLHPGSLDASHAKNRKIYIMRHGERVDFTFGT-WI 511
                   ::.:|  .|..||:.:|                 ...|.:::.|||||:|..||. ||
Zfish   360 -------VICQP--MQMLRPNQSL-----------------LPKRTLFVCRHGERMDVVFGKHWI 398

  Fly   512 PYCFDEFGNYMRKDLNMPKTLPRRKNSPEGWQNDSPLTNVGVYQANLIGQALLEAQVQIDHVYCS 576
            ..|||..|.|:|.:||||.:||.|......:..|.|:|..|..||.|:|:||.|:...:|.||||
Zfish   399 TQCFDAKGRYVRSNLNMPLSLPARSGGYRDYDKDCPITVFGSTQARLVGEALFESHTVVDFVYCS 463

  Fly   577 PSYRCIQTCTSALEGLKLTGKQKIKLEPGLFEWMAWYP-SGVPDWLTKNELTEAKFDVDLDYEPV 640
            ||.||:||..:.|.||:..||.||::|||||||..|.. :.:|.|:...:|..|...||..|.|.
Zfish   464 PSLRCVQTAHNILRGLQKDGKTKIRVEPGLFEWTKWVSGTSLPAWIPPTDLAAANLSVDTTYRPH 528

  Fly   641 QPASELTARLKESTEQFYERNHDVILQLLEQ--TTGN-ILVVAHATTLDTCSRQLTGGVPRSTNE 702
            .|.|:||  :.||.|.:..|:..|..::|.:  ..|| :|:||||::|:.|:||:.|..|:::.:
Zfish   529 IPISKLT--VSESYETYISRSFQVTREILSECNNLGNTVLIVAHASSLEACTRQIQGLTPQNSKD 591

  Fly   703 LRQVIHKIPYCSLATVEQV--DGVWKLVEPECLPVTHSKNPRFEW 745
            ..||:.||||......|::  .|||:||:|..||:||..|..|.|
Zfish   592 FVQVVRKIPYLGFCACEEMGETGVWQLVDPPILPLTHGPNHSFNW 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13604	NP_001262894.1	UBA_UBS3B	23..60	CDD:270486	22/36 (61%)
		SH3_UBASH3	275..333	CDD:212725	24/57 (42%)
		His_Phos_1	494..728	CDD:278716	101/240 (42%)
ubash3ba	XP_001923885.2	UBA_UBS3B	29..65	CDD:270486	22/35 (63%)
		LigT	<114..>206	CDD:224431	38/124 (31%)
		SH3	245..306	CDD:302595	24/60 (40%)
		HP_PGM_like	379..615	CDD:132718	98/237 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584106
Domainoid	1	1.000	139	1.000	Domainoid score	I4749
eggNOG	1	0.900	-	-		E1_COG0406
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13152
Inparanoid	1	1.050	469	1.000	Inparanoid score	I1487
OMA	1	1.010	-	-		QHG45538
OrthoDB	1	1.010	-	-		D130139at33208
OrthoFinder	1	1.000	-	-		FOG0002396
OrthoInspector	1	1.000	-	-		otm24640
orthoMCL	1	0.900	-	-		OOG6_102745
Panther	1	1.100	-	-	LDO	PTHR16469
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3907
SonicParanoid	1	1.000	-	-		X1080
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800