Protein Alignment Epp and UBASH3A

DIOPT Version :10

• Sequence 1: NP_001262894.1
• Gene: Epp / 42840
• FlyBaseID: FBgn0039137
• Length: 763
• Species: Drosophila melanogaster
• Sequence 2: XP_047296787.1
• Gene: UBASH3A / 53347
• HGNCID: 12462
• Length: 676
• Species: Homo sapiens
• Alignment Length: 763
• Identity: 242/763 - (31%)
• Similarity: 357/763 - (46%)
• Gaps: 146/763 - (19%)

  Fly    19 KQHLTP--LQTLLQMGFPRHRAEKALASTGNRGVQIASDWLLAHVNDGTLDECAPREYIIYACPT 81
            |...:|  |:.||.||||.|.|.||||:||.:..:.|..||..|.||.:||:..|:||.::.|||
Human    17 KSRSSPSLLEPLLAMGFPVHTALKALAATGRKTAEEALAWLHDHCNDPSLDDPIPQEYALFLCPT 81

  Fly    82 GPFLQQLEEFWAKSRQMCGWNGAHNYVPHITLVSFFKAPD---ECSLQLSKALKQVVDMTGALLD 143
            ||.|::|:|||.:|::.|..|.||...||:||..||...|   ||   |.:|||:..|.......
Human    82 GPLLEKLQEFWRESKRQCAKNRAHEVFPHVTLCDFFTCEDQKVEC---LYEALKRAGDRLLGSFP 143

  Fly   144 RPLKLEPYMSQNFMGFFVAEEDANYLKRLALQYVKEVSNSIISDTYEQLDAIVACFPWCG---AV 205
            ..:.|..:.|.:::||||:...|:.::..|:.:..|.  |:::.|......|.:..|..|   .:
Human   144 TAVPLALHSSISYLGFFVSGSPADVIREFAMTFATEA--SLLAGTSVSRFWIFSQVPGHGPNLRL 206

  Fly   206 SSGTRCIPRS----SRSISLEPHVKSLHLTLAYQFPQAQFNALKALVETLDASCASNWELRLYSR 266
            |:.||....|    .:..|::|..|.||||||::|.......|:.|...:....:..|...||||
Human   207 SNLTRASFVSHYILQKYCSVKPCTKQLHLTLAHKFYPHHQRTLEQLARAIPLGHSCQWTAALYSR 271

  Fly   267 DPRLATKQVQKVVYPHNPHETDELELRIGDYIYLNTEVVDSSSDGWAEGISWLTGSTGHLPVNYT 331
            |.|....|..:.::.:.|...|||.|..||||:::....|.:|:||..|||..||..|.||.|||
Human   272 DMRFVHYQTLRALFQYKPQNVDELTLSPGDYIFVDPTQQDEASEGWVIGISQRTGCRGFLPENYT 336

  Fly   332 ERTAESDAWTLHRVVQLSKSVASSLTSAEDLDIVDGRSISTEPDDRQNTAHPDIIEGSSFEESEQ 396
            :|.:|||.|..||:...  |:|:.|.|.:|                             .|.|.:
Human   337 DRASESDTWVKHRMYTF--SLATDLNSRKD-----------------------------GEASSR 370

  Fly   397 SVEKYLRQTLKPCLELPSVQLLNSHNLTHQHNPNTPTIEITTNMSSSSTSMSKQPVDEILVEPPA 461
            ...::|.||.:   .|.|:|
Human   371 CSGEFLPQTAR---SLSSLQ--------------------------------------------- 387

  Fly   462 AQPPRPDDTLSVHSDHSLHPGSLDASHAKNRKIYIMRHGERVDFTFG-TWIPYCFDEFGNYMRKD 525
                                 :|.|:.|: :.:.::|||||||..|| .|:..|....|.|.|.|
Human   388 ---------------------ALQATVAR-KSVLVVRHGERVDQIFGKAWLQQCSTPDGKYYRPD 430

  Fly   526 LNMPKTLPRRKNSPEGWQNDSPLTNVGVYQAN--------LIGQALLEAQVQIDHVYC---SPSY 579
            ||.|.:||||....:.::||.||::.|::|:.        |:|:......|..:...|   .||.
Human   431 LNFPCSLPRRSRGIKDFENDPPLSSCGIFQSRIAGMFEDCLVGKGTRYWTVVSESALCLPPQPSA 495

  Fly   580 RCIQTCTS-----ALEGLKLTGKQKIKLEPGLFEWMAWYPSG--VPDWLTKNELTEAKFDVDLDY 637
            .|.:..:|     .|| |||..|.||::|||:|||..| .:|  .|..::..||.||.|::|.||
Human   496 VCRRPNSSWKVSENLE-LKLEKKIKIRVEPGIFEWTKW-EAGKTTPTLMSLEELKEANFNIDTDY 558

  Fly   638 EPVQPASELTARLKESTEQFYERNHDVILQLLE---QTTGNILVVAHATTLDTCSRQLTGGVPRS 699
            .|..|.|.|..  .||.:::.:|....::|::.   |.||.||:|:|.:|||:|:|.|.|..||.
Human   559 RPAFPLSALMP--AESYQEYMDRCTASMVQIVNTCPQDTGVILIVSHGSTLDSCTRPLLGLPPRE 621

  Fly   700 TNELRQVIHKIPYCSLATVEQ--VDGVWKLVEPECLPVTHSKNPRFEW 745
            ..:..|::.|||...:...|:  .:|.|:||.|....:||..|..|.|
Human   622 CGDFAQLVRKIPSLGMCFCEENKEEGKWELVNPPVKTLTHGANAAFNW 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Epp	NP_001262894.1	UBA_UBS3B	23..60	CDD:270486	19/38 (50%)
		SH3_UBASH3	275..333	CDD:212725	24/57 (42%)
		PhoE	492..728	CDD:440175	92/259 (36%)
UBASH3A	XP_047296787.1	UBA_UBS3A_like	25..61	CDD:270485	18/35 (51%)
		ThpR	76..>166	CDD:441123	35/92 (38%)
		SH3_UBASH3A	279..338	CDD:212870	25/58 (43%)
		His_Phos_1	<511..627	CDD:459751	48/119 (40%)