DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG13604 and PFKFB2

DIOPT Version :9

Sequence 1:NP_001262894.1 Gene:CG13604 / 42840 FlyBaseID:FBgn0039137 Length:763 Species:Drosophila melanogaster
Sequence 2:NP_006203.2 Gene:PFKFB2 / 5208 HGNCID:8873 Length:505 Species:Homo sapiens


Alignment Length:276 Identity:62/276 - (22%)
Similarity:95/276 - (34%) Gaps:94/276 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   488 HAKNRKIYIMRHGERVDFTFGTWIPYCFDEFGNYMRKDLNMPKTLPRRKNSPEGWQNDSPLTNVG 552
            |.:.|.||:.||||              .|| |.:.|                 ...||.|:..|
Human   246 HVQPRTIYLCRHGE--------------SEF-NLLGK-----------------IGGDSGLSVRG 278

  Fly   553 VYQANLIGQALLEAQVQIDHVYCSPSYRCIQTCTSALEGLKLTGKQKIKLEPGLFEWMAWYPSGV 617
            ...|..:.:.|.|.::....|:.|...|.|||..|.                           ||
Human   279 KQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESL---------------------------GV 316

  Fly   618 P--DWLTKNELTEAKFDVDLDYEPVQP--ASELTARLK----------ESTEQFYERNHDVILQL 668
            |  .|...||: :|....::.|..::.  ..|...|.:          ||.:...:|...||::|
Human   317 PYEQWKILNEI-DAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMEL 380

  Fly   669 LEQTTGNILVVAHATTLDTCSRQLTGGVPRSTNELRQVIHKIPY--CSLATVEQVDGVWKLVEPE 731
            ..|  ||:||::|...: .|  .|...:.:..:||       ||  |.|.|:.::..|....:.|
Human   381 ERQ--GNVLVISHQAVM-RC--LLAYFLDKGADEL-------PYLRCPLHTIFKLTPVAYGCKVE 433

  Fly   732 CLPV------THSKNP 741
            .:.:      ||...|
Human   434 TIKLNVEAVNTHRDKP 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG13604NP_001262894.1 UBA_UBS3B 23..60 CDD:270486
SH3_UBASH3 275..333 CDD:212725
His_Phos_1 494..728 CDD:278716 56/249 (22%)
PFKFB2NP_006203.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
6-phosphofructo-2-kinase 2..248 1/1 (100%)
6PF2K 26..249 CDD:396253 1/2 (50%)
Fructose-2,6-bisphosphatase 249..505 61/273 (22%)
His_Phos_1 252..435 CDD:395236 57/254 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 445..505 2/5 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0406
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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