DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31140 and Dgkb

DIOPT Version :9

Sequence 1:	NP_001262893.1	Gene:	CG31140 / 42836	FlyBaseID:	FBgn0051140	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_008762871.2	Gene:	Dgkb / 54248	RGDID:	2488	Length:	803	Species:	Rattus norvegicus

Alignment Length:	486	Identity:	153/486 - (31%)
Similarity:	236/486 - (48%)	Gaps:	116/486 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1039 TGLSQRNYEQILNKYVTDENKFISIGPIYYEYGSVVLTFEDSMKAVRAFYNLRETIIEDKKLLVL 1103
            |...::...|..|| |||:||                           ........::.:.|.:.
  Rat   394 TAKKEKGSSQQPNK-VTDKNK---------------------------MQRANSVTMDGQGLQIT 430

  Fly  1104 LLPNIEPSMVPSDVRPLLVFVNVKSGGCQGLELISSFRKLLNPYQVFDLDNGGPLPGYVQPITVF 1168
            .:|.         ..|||||||.||||.||..:...|:.||||.||:.|...||:||
  Rat   431 PIPG---------THPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPG-------- 478

  Fly  1169 VIRPLIFDSIISLYVFRQITNYKILVCGGDGTIGWVLQCLDNVGQDSECSSPPCAIVPLGTGNDL 1233
                        |:.||.:.::::|.||||||:||:|.|::..   :....||.||:||||||||
  Rat   479 ------------LHFFRDVPDFRVLACGGDGTVGWILDCIEKA---NVVKHPPVAILPLGTGNDL 528

  Fly  1234 ARVLCWGSGYTGGEDPLNLLRDVIEAEEIRLDRWTVVFHPEDKPEEPAMKAPSQTTGGAQNEDNS 1298
            ||.|.||.||. ||:.:.:|:|:..:.||.||||.....|.||.|:               .|..
  Rat   529 ARCLRWGGGYE-GENLMKILKDIESSTEIMLDRWKFEVTPNDKDEK---------------GDPV 577

  Fly  1299 QIFVMNNYFGIGIDADLCLDFHNAREENPNQFNSRLRNKGYYVKMGLRKIVGRKAVKDLQKELRL 1363
            ...::||||.||:||.:...||..||::|.:||||::||.:|.:.|..:... ...|.|.:.:.:
  Rat   578 PYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFS-ATCKKLHESVEI 641

  Fly  1364 EVDGKIVELPPV--DGIIILNILSWGSGANPWGPD-----------------------KDDQFST 1403
            |.||..::|..:  :||.||||.|...|:|.||..                       |:.:|::
  Rat   642 ECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKKRSHRRIEKKGSDKRPTLTDAKELKFAS 706

  Fly  1404 PNHYDGMLEVVGVTGVVHLGQIQSGIRTA-MRIAQGGHIKIHLNTDMPVQVDGEPWIQSPGDVVV 1467
            .:..|.:|||||:.|.:.:|||.:|:::| .|:||...:.|..:..:|:|:|||||:|:|..:.:
  Rat   707 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKI 771

  Fly  1468 L-------------KSALKATMLKKTKSKRR 1485
            .             |:.|..:::|:|:::.:
  Rat   772 THKNQAPMLMGPPPKTGLFCSLIKRTRNRSK 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31140	NP_001262893.1	C1	6..55	CDD:237996
		C1	69..116	CDD:197519
		C1_1	135..185	CDD:278556
		RA	833..922	CDD:279168
		UBQ	923..1022	CDD:294102
		RRM_SF	1032..1102	CDD:302621	10/62 (16%)
		DAGKc	1121..1266	CDD:214487	63/144 (44%)
		DAGK_acc	1302..1457	CDD:279003	60/180 (33%)
Dgkb	XP_008762871.2	DAG_kinase_N	6..148	CDD:405237
		EFh	152..221	CDD:238008
		C1_DGKbeta_rpt1	237..302	CDD:410395
		C1_DGKbeta_rpt2	307..365	CDD:410441
		DAGKc	439..560	CDD:214487	63/144 (44%)
		DAGKa	581..761	CDD:214486	60/180 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810