DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31140 and DGKQ

DIOPT Version :9

Sequence 1:NP_001262893.1 Gene:CG31140 / 42836 FlyBaseID:FBgn0051140 Length:1571 Species:Drosophila melanogaster
Sequence 2:NP_001338.2 Gene:DGKQ / 1609 HGNCID:2856 Length:942 Species:Homo sapiens


Alignment Length:1494 Identity:388/1494 - (25%)
Similarity:547/1494 - (36%) Gaps:645/1494 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 GHSFVKKTFHKPTYCHHCSDLLWGLIQQGYICEVCNFIIHERCVSSVVTPCSGIAPCIIKNPVAH 69
            ||||.|.|..|||:||.|||.:|||  .|::|:||||:.||:|:..|..||:.:||.:::.||||
Human    60 GHSFRKVTLTKPTFCHLCSDFIWGL--AGFLCDVCNFMSHEKCLKHVRIPCTSVAPSLVRVPVAH 122

  Fly    70 CWSEPTHHKRKFCTVCRKRLDETPAVHCLVCEYFAHIECQDFAVPDCTENATYVPGKELLNVKHQ 134
            |:.....||||||.||||.| |.||:||.|||...|.:|..||..||.:  .:..|.:..:. |.
Human   123 CFGPRGLHKRKFCAVCRKVL-EAPALHCEVCELHLHPDCVPFACSDCRQ--CHQDGHQDHDT-HH 183

  Fly   135 HHWREGNLPSTSKCAYCKKTCWSSECLTGYRCEWCGMTTHAGCRMYLPTECNFGILQPIYLPPHS 199
            ||||||||||.::|..|:|||.||:.|.|.||||||:..|:.|...|..||.||.|:.:.|||  
Human   184 HHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLRSLVLPP-- 246

  Fly   200 VSIPRTEVPIEAIIGVQVKSKTSLVRDYSCPSPDLSCPIPGAGSGSLTSLGLKELLELHRQRLEQ 264
                                                                             
Human   247 ----------------------------------------------------------------- 246

  Fly   265 SKQHFLLSTPPTPTSCGSISLCHSPTPSSLTVGETSNEAEQDRERDQDQPEEEPEEENTEQDSAL 329
                                                                             
Human   247 ----------------------------------------------------------------- 246

  Fly   330 QLTTSTSNVIGNLQKWPSANSSLHLLYTNLFRKLGQGKRRRKRGISSGGLSPSEDEDDVDGGVCD 394
                                                                             
Human   247 ----------------------------------------------------------------- 246

  Fly   395 ISGGDLSDDYDHCDVALRRRSLRSRQPRDVSETDYHGDAEAEAEGETVPRESCYETSDTGGELTN 459
                                                                             
Human   247 ----------------------------------------------------------------- 246

  Fly   460 TDDLDSSLNLISNLSYNSSNNSNACNVPGGATAPDARNTATTSTTAPGKSGHALSVQGGRQQPKT 524
                                   ||                                        
Human   247 -----------------------AC---------------------------------------- 248

  Fly   525 GALAQIKPKPKPILMPKHKAQGKGGSLSSPLSNSNSSDCSSASPSAPATLLQLSPVGRSKSFQES 589
                                                              ::|.|.|.||     
Human   249 --------------------------------------------------VRLLPGGFSK----- 258

  Fly   590 AAITAVSRYKKYGRGLFQRRRSKRSPKNAVGVGGKSNYSLDRLSQNIEITIQDEDGNFHPYDDNY 654
                                                                             
Human   259 ----------------------------------------------------------------- 258

  Fly   655 HMLAGRLDATDVDDDVGFDDLYLDDRPSGASDDVAFAGDISDGGASSRSRASDASDGHVLGRLLR 719
                                                                             
Human   259 ----------------------------------------------------------------- 258

  Fly   720 QVRQGLSVGWRKPRYQKRRARSISEEFSSGDTPRFKDEESASKAESGHGPSSGGAGGGGGSGGAG 784
                                           |..|:..|:|...|              |..||.
Human   259 -------------------------------TQSFRIVEAAEPGE--------------GGDGAD 278

  Fly   785 GSSAAGASASAAGGSSGHYRPDSGSGHKSDKSEKDREKKEKEREEKDIEMIKVFDGNNSFRRQQY 849
            ||:|.|.      |......|:||.                       :.:|:|||:::.||.|:
Human   279 GSAAVGP------GRETQATPESGK-----------------------QTLKIFDGDDAVRRSQF 314

  Fly   850 RVIIVQRTYTLEQLLTTALRAFHITRDPQAFYLTDLYAPAGMEDTPMLDPTPVLNLVHLEGKRP- 913
            |::.|.|....|::|..||||.||..||....|..| .|:...............::..||:.| 
Human   315 RLVTVSRLAGAEEVLEAALRAHHIPEDPGHLELCRL-PPSSQACDAWAGGKAGSAVISEEGRSPG 378

  Fly   914 -------AIYLRFHDRDRGHVRVYPGKLQCSMLEDPYVSVPVDNSTVIKDLIRDALDKFGLQDNQ 971
                   |..:|...|.:..:::|||.|:..:   .||||.|...:..:.::.:.|...|.|...
Human   379 SGEATPEAWVIRALPRAQEVLKIYPGWLKVGV---AYVSVRVTPKSTARSVVLEVLPLLGRQAES 440

  Fly   972 IQDYRCSEVLLDRGVTERILSWNERP-WDIMKQLGKDSIRQMELMRFYMQHKQDPHGPNIALFVG 1035
            .:.::..||.:.....:|.:..:|:| .|.::.:.:.|:||:...|||:...:|. .|:::||||
Human   441 PESFQLVEVAMGCRHVQRTMLMDEQPLLDRLQDIRQMSVRQVSQTRFYVAESRDV-APHVSLFVG 504

  Fly  1036 NLPTGLSQRNYEQILNKYVTDENKFISIGPIYYEYGSVVLTFEDSMKAVRAFYNLRETIIEDKKL 1100
            .||.|||...|..:|::....:...:|:..||...|:|||......:|.|.:..|::..:..:.|
Human   505 GLPPGLSPEEYSSLLHEAGATKATVVSVSHIYSSQGAVVLDVACFAEAERLYMLLKDMAVRGRLL 569

  Fly  1101 LVLLLPNIEPSMVPSDVRPLLVFVNVKSGGCQGLELISSFRKLLNPYQVFDLDNGGPLPGYVQPI 1165
            ..|:||::..:.:|.|..|||||||.||||.:|.:|:.||||||||:|||||.|||||||     
Human   570 TALVLPDLLHAKLPPDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPG----- 629

  Fly  1166 TVFVIRPLIFDSIISLYVFRQITNYKILVCGGDGTIGWVLQCLDNVGQDSECSSPPCAIVPLGTG 1230
                           |::|.|:..:::||||||||:||||..|:.......|..|..||:|||||
Human   630 ---------------LHLFSQVPCFRVLVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTG 679

  Fly  1231 NDLARVLCWGSGYTGGEDPLNLLRDVIEAEEIRLDRWTVVFHPEDKPEEPAMKAPSQTTGGAQNE 1295
            |||.|||.||:||: ||||.::|..|.||:.:.:||||::....:             .|.|:|:
Human   680 NDLGRVLRWGAGYS-GEDPFSVLLSVDEADAVLMDRWTILLDAHE-------------AGSAEND 730

  Fly  1296 ----DNSQIFVMNNYFGIGIDADLCLDFHNAREENPNQFNSRLRNKGYYVKMGLRKIVGRKAVKD 1356
                :..:|..|:||.||||||:|.||||.||||.|.:|.|||.|||.||::||:||   ...:.
Human   731 TADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQKI---SHSRS 792

  Fly  1357 LQKELRLEVDGKIVELPPVDGIIILNILSWGSGANPWGPDKDDQFSTPNHYDGMLEVVGVTGVVH 1421
            |.|::||:|:.:.||||.::|:|.:||.||||||:.||.|.|.:|..|...||:|||||||||||
Human   793 LHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLWGSDSDTRFEKPRMDDGLLEVVGVTGVVH 857

  Fly  1422 LGQIQSGIRTAMRIAQGGHIKIHLNTDMPVQVDGEPWIQSPGDVVVLKSALKATMLKKTKSKRR 1485
            :||:|.|:|:.:|||||.:.::.|....|||||||||:|:||.:::..:..|..||:|.|.|.|
Human   858 MGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGHMIISAAGPKVHMLRKAKQKPR 921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31140NP_001262893.1 C1 6..55 CDD:237996 26/48 (54%)
C1 69..116 CDD:197519 25/46 (54%)
C1_1 135..185 CDD:278556 28/49 (57%)
RA 833..922 CDD:279168 28/96 (29%)
UBQ 923..1022 CDD:294102 24/99 (24%)
RRM_SF 1032..1102 CDD:302621 22/69 (32%)
DAGKc 1121..1266 CDD:214487 74/144 (51%)
DAGK_acc 1302..1457 CDD:279003 87/154 (56%)
DGKQNP_001338.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59
C1 61..108 CDD:237996 26/48 (54%)
C1 122..169 CDD:294036 26/47 (55%)
C1 186..234 CDD:237996 26/47 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 269..295 10/45 (22%)
UBQ 296..>348 CDD:294102 21/74 (28%)
DAGK_delta_RA 395..492 CDD:176378 24/99 (24%)
LXXLL motif 1. /evidence=ECO:0000305|PubMed:17664281 555..559 0/3 (0%)
LXXLL motif 2. /evidence=ECO:0000305|PubMed:17664281 574..578 2/3 (67%)
DAGKc 590..714 CDD:214487 74/144 (51%)
DAGKa 741..893 CDD:214486 87/154 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 908..942 7/14 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142491
Domainoid 1 1.000 185 1.000 Domainoid score I3407
eggNOG 1 0.900 - - E1_KOG1169
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20352
Inparanoid 1 1.050 693 1.000 Inparanoid score I687
Isobase 1 0.950 - 0 Normalized mean entropy S5026
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1275907at2759
OrthoFinder 1 1.000 - - FOG0008476
OrthoInspector 1 1.000 - - oto91008
orthoMCL 1 0.900 - - OOG6_107260
Panther 1 1.100 - - LDO PTHR11255
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X5675
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.710

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