DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31140 and DGKG

DIOPT Version :9

Sequence 1:	NP_001262893.1	Gene:	CG31140 / 42836	FlyBaseID:	FBgn0051140	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_001337.2	Gene:	DGKG / 1608	HGNCID:	2853	Length:	791	Species:	Homo sapiens

Alignment Length:	406	Identity:	151/406 - (37%)
Similarity:	213/406 - (52%)	Gaps:	75/406 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly  1112 MVPS-DVRPLLVFVNVKSGGCQGLELISSFRKLLNPYQVFDLDNGGPLPGYVQPITVFVIRPLIF 1175
            ::|: ...||||.||.||||.||..::..|..||||.|||:||||||.||
Human   426 IIPTPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPG--------------- 475

  Fly  1176 DSIISLYVFRQITNYKILVCGGDGTIGWVLQCLDNVGQDSECSSPPCAIVPLGTGNDLARVLCWG 1240
                 |..||...::::|.||||||:||:|.|:|..   :....||.|::||||||||||.|.||
Human   476 -----LNFFRDTPDFRVLACGGDGTVGWILDCIDKA---NFAKHPPVAVLPLGTGNDLARCLRWG 532

  Fly  1241 SGYTGGEDPLNLLRDVIEAEEIRLDRWTVVFHPEDKPEEPAMKAPSQTTGGAQNEDNSQIFVMNN 1305
            .||.|| ....:|:|:.::..:.||||    |.|..|.|.           .:|.|.....:|||
Human   533 GGYEGG-SLTKILKDIEQSPLVMLDRW----HLEVIPREE-----------VENGDQVPYSIMNN 581

  Fly  1306 YFGIGIDADLCLDFHNAREENPNQFNSRLRNKGYYVKMGLRKIVGRKAVKDLQKELRLEVDGKIV 1370
            ||.||:||.:...||..||::|.:||||::||.:|.:.|..:... ...|.|...:.||.||..|
Human   582 YFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFA-ATCKKLHDHIELECDGVGV 645

  Fly  1371 ELPPV--DGIIILNILSWGSGANPWGPDKDD-----------------QFSTPNHYDGMLEVVGV 1416
            :|..:  :||.||||.|...|.|.||.:|.:                 :|...:..|.:|||||:
Human   646 DLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCVQDLSDQLLEVVGL 710

  Fly  1417 TGVVHLGQIQSGIRTA-MRIAQGGHIKIHLNTDMPVQVDGEPWIQSPGDVVVLKSALKATML--- 1477
            .|.:.:|||.:|:::| .|:||...:.|..|..:|:|||||||:| |...:.:....:|.|:
Human   711 EGAMEMGQIYTGLKSAGRRLAQCASVTIRTNKLLPMQVDGEPWMQ-PCCTIKITHKNQAPMMMGP 774

  Fly  1478 ----------KKTKSK 1483
                      :|::||
Human   775 PQKSSFFSLRRKSRSK 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31140	NP_001262893.1	C1	6..55	CDD:237996
		C1	69..116	CDD:197519
		C1_1	135..185	CDD:278556
		RA	833..922	CDD:279168
		UBQ	923..1022	CDD:294102
		RRM_SF	1032..1102	CDD:302621
		DAGKc	1121..1266	CDD:214487	64/144 (44%)
		DAGK_acc	1302..1457	CDD:279003	65/174 (37%)
DGKG	NP_001337.2	DAG_kinase_N	5..175	CDD:291199
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	82..103
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..154
		EFh	179..248	CDD:238008
		EF-hand_7	180..244	CDD:290234
		C1	272..321	CDD:237996
		C1	336..377	CDD:197519
		DAGKc	436..557	CDD:214487	64/144 (44%)
		DAGKa	578..752	CDD:214486	65/174 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..791		5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810