DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31140 and DGKB

DIOPT Version :9

Sequence 1:NP_001262893.1 Gene:CG31140 / 42836 FlyBaseID:FBgn0051140 Length:1571 Species:Drosophila melanogaster
Sequence 2:NP_001337634.1 Gene:DGKB / 1607 HGNCID:2850 Length:804 Species:Homo sapiens


Alignment Length:419 Identity:148/419 - (35%)
Similarity:224/419 - (53%) Gaps:84/419 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  1108 IEPSMVPSDVRPLLVFVNVKSGGCQGLELISSFRKLLNPYQVFDLDNGGPLPGYVQPITVFVIRP 1172
            ::.:.||. ..|||||||.||||.||..:...|:.||||.||:.|...||:||            
Human   428 LQVTPVPG-THPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPG------------ 479

  Fly  1173 LIFDSIISLYVFRQITNYKILVCGGDGTIGWVLQCLD--NVGQDSECSSPPCAIVPLGTGNDLAR 1235
                    |..||.:.::::|.||||||:||||.|::  |||:     .||.||:||||||||||
Human   480 --------LNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGK-----HPPVAILPLGTGNDLAR 531

  Fly  1236 VLCWGSGYTGGEDPLNLLRDVIEAEEIRLDRWTVVFHPEDKPEEPAMKAPSQTTGGAQNEDNSQI 1300
            .|.||.||. ||:.:.:|:|:..:.||.||||.....|.||.|:               .|....
Human   532 CLRWGGGYE-GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEK---------------GDPVPY 580

  Fly  1301 FVMNNYFGIGIDADLCLDFHNAREENPNQFNSRLRNKGYYVKMGLRKIVGRKAVKDLQKELRLEV 1365
            .::||||.||:||.:...||..||::|.:||||::||.:|.:.|..:... ...|.|.:.:.:|.
Human   581 SIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFS-ATCKKLHESVEIEC 644

  Fly  1366 DGKIVELPPV--DGIIILNILSWGSGANPWGPD-----------------------KDDQFSTPN 1405
            ||..::|..:  :||.||||.|...|:|.||..                       |:.:|::.:
Human   645 DGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQD 709

  Fly  1406 HYDGMLEVVGVTGVVHLGQIQSGIRTA-MRIAQGGHIKIHLNTDMPVQVDGEPWIQSPGDVVVL- 1468
            ..|.:|||||:.|.:.:|||.:|:::| .|:||...:.|..:..:|:|:|||||:|:|..:.:. 
Human   710 LSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITH 774

  Fly  1469 ------------KSALKATMLKKTKSKRR 1485
                        |:.|..:::|:|:::.:
Human   775 KNQAPMLMGPPPKTGLFCSLVKRTRNRSK 803

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31140NP_001262893.1 C1 6..55 CDD:237996
C1 69..116 CDD:197519
C1_1 135..185 CDD:278556
RA 833..922 CDD:279168
UBQ 923..1022 CDD:294102
RRM_SF 1032..1102 CDD:302621
DAGKc 1121..1266 CDD:214487 67/146 (46%)
DAGK_acc 1302..1457 CDD:279003 60/180 (33%)
DGKBNP_001337634.1 DAG_kinase_N 6..149 CDD:373103
EFh 153..222 CDD:238008
C1 245..294 CDD:237996
C1_1 310..359 CDD:365894
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 385..406
DAGKc 440..561 CDD:214487 67/146 (46%)
DAGKa 582..762 CDD:214486 60/180 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..694 2/20 (10%)
Required for association with membranes and function in neurite spine formation. /evidence=ECO:0000305|PubMed:11719522 771..804 4/33 (12%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1169
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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