DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31140 and DGKA

DIOPT Version :9

Sequence 1:	NP_001262893.1	Gene:	CG31140 / 42836	FlyBaseID:	FBgn0051140	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_016874389.1	Gene:	DGKA / 1606	HGNCID:	2849	Length:	891	Species:	Homo sapiens

Alignment Length:	420	Identity:	146/420 - (34%)
Similarity:	218/420 - (51%)	Gaps:	75/420 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1070 YGSVVLTFEDSMKAVRAFYNLRETIIEDKKLLVLLLPNIEPSMVPSDVRPLLVFVNVKSGGCQGL 1134
            |.||:.:..|     |......:..::|..|.......|:|  || :..|||||||.||||.||.
Human   491 YPSVLASGPD-----RKNSKTSQKTMDDLNLSTSEALRIDP--VP-NTHPLLVFVNPKSGGKQGQ 547

  Fly  1135 ELISSFRKLLNPYQVFDLDNGGPLPGYVQPITVFVIRPLIFDSIISLYVFRQITNYKILVCGGDG 1199
            .::..|:.:|||.|||:|...||                    .|.|.:|:.:.:.:||||||||
Human   548 RVLWKFQYILNPRQVFNLLKDGP--------------------EIGLRLFKDVPDSRILVCGGDG 592

  Fly  1200 TIGWVLQCLDNVGQDSECSSPPCAIVPLGTGNDLARVLCWGSGYTGGEDPLNLLRDVIEAEEIRL 1264
            |:||:|:.:|.....   ..||.|::||||||||||.|.||.||. |::...:|:|:..::.:.:
Human   593 TVGWILETIDKANLP---VLPPVAVLPLGTGNDLARCLRWGGGYE-GQNLAKILKDLEMSKVVHM 653

  Fly  1265 DRWTVVFHPEDKPEEPAMKAPSQTTGGAQNEDNSQIFVMNNYFGIGIDADLCLDFHNAREENPNQ 1329
            |||:|...|: :.||.:...|.|              ::||||.||:||.:...||..||:.|.:
Human   654 DRWSVEVIPQ-QTEEKSDPVPFQ--------------IINNYFSIGVDASIAHRFHIMREKYPEK 703

  Fly  1330 FNSRLRNKGYYVKMGLRKIVGRKAVKDLQKELRLEVDGKIVELP--PVDGIIILNILSWGSGANP 1392
            ||||::||.:|.:....:.: ....|.|::.|.:|:.||.::|.  .::||.:|||.|...|:|.
Human   704 FNSRMKNKLWYFEFATSESI-FSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSNL 767

  Fly  1393 WG----PDKD------------------DQFST--PNHYDGMLEVVGVTGVVHLGQIQSGIRTA- 1432
            ||    |..|                  |...|  |:..|..|||||:.|.:.:|||.:.::.|
Human   768 WGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAG 832

  Fly  1433 MRIAQGGHIKIHLNTDMPVQVDGEPWIQSP 1462
            .|:|:...|..|....:|:|:|||||:|:|
Human   833 RRLAKCSEITFHTTKTLPMQIDGEPWMQTP 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31140	NP_001262893.1	C1	6..55	CDD:237996
		C1	69..116	CDD:197519
		C1_1	135..185	CDD:278556
		RA	833..922	CDD:279168
		UBQ	923..1022	CDD:294102
		RRM_SF	1032..1102	CDD:302621	7/31 (23%)
		DAGKc	1121..1266	CDD:214487	58/144 (40%)
		DAGK_acc	1302..1457	CDD:279003	61/181 (34%)
DGKA	XP_016874389.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810