DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AP-1sigma and AP2S1

DIOPT Version :9

Sequence 1:	NP_001247273.1	Gene:	AP-1sigma / 42835	FlyBaseID:	FBgn0039132	Length:	157	Species:	Drosophila melanogaster
Sequence 2:	XP_011524725.1	Gene:	AP2S1 / 1175	HGNCID:	565	Length:	172	Species:	Homo sapiens

Alignment Length:	146	Identity:	63/146 - (43%)
Similarity:	94/146 - (64%)	Gaps:	14/146 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 FMLLFSRQGKLRLQKWYMAYPDKVKKKITRELVTTILARKPKMCSF--------------LEWKD 54
            |:|:.:|.||.||.||||.:.|..|:|:..|:...:..|..|..:|              |::::
Human    20 FILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEVLAISVADSLSVLQFRN 84

  Fly    55 CKIVYKRYASLYFCCAIEQNDNELLTLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDELLI 119
            .||:|:|||.||||..::.|||.|..||.||.:||:|::||.:|||||::|||.|.|.::||:.:
Human    85 FKIIYRRYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFL 149

  Fly   120 GGEIQETSKKNVLKAI 135
            .|||:|||:..|||.:
Human   150 AGEIRETSQTKVLKQL 165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AP-1sigma	NP_001247273.1	AP1_sigma	4..145	CDD:341435	63/146 (43%)
AP2S1	XP_011524725.1	Clat_adaptor_s	18..172	CDD:250451	63/146 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5030
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53551
OrthoDB	1	1.010	-	-		D1307450at2759
OrthoFinder	1	1.000	-	-		FOG0000441
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X298
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.830