DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluProRS and Qars

DIOPT Version :9

Sequence 1:	NP_524471.2	Gene:	GluProRS / 42834	FlyBaseID:	FBgn0005674	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_598555.2	Gene:	Qars / 97541	MGIID:	1915851	Length:	775	Species:	Mus musculus

Alignment Length:	603	Identity:	173/603 - (28%)
Similarity:	259/603 - (42%)	Gaps:	93/603 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 QKVLQSLPEDAKVKRSPQSSKEQTPAKTGERKQEGKFVDLPGAEM----------------GKVV 205
            :|..:.:.|..:|.....|..||...:..:..:.|:....||..:                |:|.
Mouse   201 RKTAKDVVEKGEVAGQTLSLMEQLRGEALKFHKPGENYKTPGYVITPYTMDLLKQHLEITGGQVR 265

  Fly   206 VRFPPEASGYLHIGHAKAALLNQYYALAFQGTLIMRFDDTNPAKETVEFENVILGDLEQLQIKPD 270
            .|||||.:|.||||||||...|..||.|..|...:|||||||.||..:|...|...:..|...|.
Mouse   266 TRFPPEPNGILHIGHAKAINFNFGYAKANNGICFLRFDDTNPEKEEAKFFTAIYDMVTWLGYTPY 330

  Fly   271 VFTHTSNYFDLMLDYCVRLIKESKAYVDDTPPEQMKLEREQRVESANRSNSVEKNLSLWEEMVKG 335
            ..|:.|:|||.:..:.|.||....|||.....|::|  ....:.|..|....|::|.|:|.|.||
Mouse   331 KVTYASDYFDQLYAWAVELIHGGLAYVCHQRVEELK--GHNPLPSPWRDRPKEESLLLFEAMRKG 393

  Fly   336 SEKGQKYCVRAKIDMSSPNGCMRDPTIYRCKNEPHPRTGTKYKVYPTYDFACPIVDAIENVTHTL 400
            .....:..:|.|:.|.  :|.| ||..||.|..||.|||.|:.:|||||:...:.|:||::||:|
Mouse   394 KFAEGEATLRMKLVME--DGKM-DPVAYRVKYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSL 455

  Fly   401 RTTEYHDRDDQFYWFIDALKLRKPYIWSYSRLNMTNTVLSKRKLTWFVDSGLVDGWDDPRFPTVR 465
            .|.|:..|...::|..:|||:..|..|.|.|||:...|:||||:...|.:|.|..|||||..|:.
Mouse   456 CTKEFQARRSSYFWLCNALKVYCPVQWEYGRLNLHYAVVSKRKILQLVAAGAVRDWDDPRLFTLT 520

  Fly   466 GIIRRGMTVEGLKEFIIAQGSSKSVVFMNWDKIWAFNKKVIDPIAPRYTA-LEKEKRVIVNVAGA 529
            .:.|||...|.:..|....|.:.:...|....:.|..:.|::..|||..| ||..:.||.|....
Mouse   521 ALRRRGFPPEAINNFCARVGVTVAQTTMEPHLLEACVRDVLNDAAPRAMAVLEPLQVVITNFPAP 585

  Fly   530 KVERIQVSVHPKDESLGKKTVLLGPRIYIDYVD--------AEALKEGENATFINWGNIL-IRKV 585
            |...|:|...|.||:.|...|.....::|:..|        .:.|..|:.....:.|.:: ::.:
Mouse   586 KPLDIRVPNFPADETKGFHQVPFASTVFIERSDFKEESEPGYKRLASGQPVGLRHTGYVIELQNI 650

  Fly   586 NKDASGNITSVDAALNLENKDFKKTLKLTWLAVEDDPSAYPPTFCVYFDNIISKAVLGKDEDFKQ 650
            .:.:||.:..::......:...|....:.|                     :|:.::.:...::.
Mouse   651 VRGSSGCVERLEVTCRRADAGEKPKAFIHW---------------------VSQPLVCEIRLYEC 694

  Fly   651 FIGHKTRD---EVP-----------------MLGDPELKKCKKGDIIQLQRRGFFKVDVAYAPPS 695
            ...||..:   |||                 .|.|..:...|..|..|.:|.|:|.||
Mouse   695 LFQHKNPEDPVEVPGGFLSDLNPASLQVVEGALVDCSVALAKPFDKFQFERLGYFSVD------- 752

  Fly   696 GYTNVPSPIVLFSIPDGH 713
                          ||.|
Mouse   753 --------------PDSH 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluProRS	NP_524471.2	PLN02907	1..715	CDD:215492	173/603 (29%)
		GST_C_GluProRS_N	76..153	CDD:198342
		tRNA-synt_1c	203..508	CDD:279135	118/304 (39%)
		tRNA-synt_1c_C	510..688	CDD:281883	40/207 (19%)
		WHEP-TRS	748..799	CDD:278865
		WHEP-TRS	821..870	CDD:278865
		WHEP-TRS	894..945	CDD:278865
		WEPRS_RNA	973..1022	CDD:238473
		WHEP-TRS	1050..1100	CDD:278865
		WHEP-TRS	1122..1168	CDD:278865
		PRK08661	1220..1714	CDD:236327
		ProRS_core_arch_euk	1224..1486	CDD:238401
		ProRS_anticodon_zinc	1492..1714	CDD:238439
Qars	NP_598555.2	GlnS	2..774	CDD:332033	173/603 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111937at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820