DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluProRS and GLN4

DIOPT Version :9

Sequence 1:	NP_524471.2	Gene:	GluProRS / 42834	FlyBaseID:	FBgn0005674	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_014811.3	Gene:	GLN4 / 854339	SGDID:	S000005694	Length:	809	Species:	Saccharomyces cerevisiae

Alignment Length:	890	Identity:	232/890 - (26%)
Similarity:	350/890 - (39%)	Gaps:	235/890 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FPDNRLLVCHSNNDVLRALARAAPDYKLYGETAIERTQIDHWLSFSLTCEDDISW-----AL--- 98
            |.|.::.....|..|..:|      |||..||                 ..|..|     ||
Yeast    16 FEDKKVKEIVKNKKVSDSL------YKLIKET-----------------PSDYQWNKSTRALVHN 57

  Fly    99 --SFLDKSIAPVTYLVANKLTIADFALFNEMHSRYEFLAAKG----------------------- 138
              ||:..:..|.:.|:.|.:...|.....::.:.::::.|.|
Yeast    58 LASFVKGTDLPKSELIVNGIINGDLKTSLQVDAAFKYVKANGEASTKMGMNENSGVGIEITEDQV 122

  Fly   139 ---IPQHVQ---------------------------RWYDLITAQPLI-QKVLQSL-PEDAK--- 168
               :.|::|                           :|.|..:.:|:| |:||:.| |:|.:
Yeast   123 RNYVMQYIQENKERILTERYKLVPGIFADVKNLKELKWADPRSFKPIIDQEVLKLLGPKDERDLI 187

  Fly   169 --------------VKRSPQSSKEQTPAKT-------------GERKQE-----GKFVDLPGAEM 201
                          .|:|..:|....|.:|             ||..|.     .:.:::.|
Yeast   188 KKKTKNNEKKKTNSAKKSSDNSASSGPKRTMFNEGFLGDLHKVGENPQAYPELMKEHLEVTG--- 249

  Fly   202 GKVVVRFPPEASGYLHIGHAKAALLNQYYALAFQGTLIMRFDDTNPAKETVEFENVILGDLEQLQ 266
            |||..|||||.:|||||||:||.::|..||....||..:|||||||.||..|:...|...:..|.
Yeast   250 GKVRTRFPPEPNGYLHIGHSKAIMVNFGYAKYHNGTCYLRFDDTNPEKEAPEYFESIKRMVSWLG 314

  Fly   267 IKPDVFTHTSNYFDLMLDYCVRLIKESKAYVDDTPPEQMKLER---------EQRVESANRSNSV 322
            .||...|::|:|||.:......|||..||||.....|::|..|         .:|....:|..|:
Yeast   315 FKPWKITYSSDYFDELYRLAEVLIKNGKAYVCHCTAEEIKRGRGIKEDGTPGGERYACKHRDQSI 379

  Fly   323 EKNLSLWEEMVKGSEKGQKYCVRAKIDMSSPNGCMRDPTIYRCKNEPHPRTGTKYKVYPTYDFAC 387
            |:||..:.:|..|..|..:..:|.|.|::||:..|.|...||..|.||||||||:::||||||..
Yeast   380 EQNLQEFRDMRDGKYKPGEAILRMKQDLNSPSPQMWDLIAYRVLNAPHPRTGTKWRIYPTYDFTH 444

  Fly   388 PIVDAIENVTHTLRTTEYHDRDDQFYWFIDALKLRKPYIWSYSRLNMTNTVLSKRKLTWFVDSGL 452
            .:||::||:||:|.|||::...:.:.|..|.:.:.:|....|.|||:|.|||||||:...||...
Yeast   445 CLVDSMENITHSLCTTEFYLSRESYEWLCDQVHVFRPAQREYGRLNITGTVLSKRKIAQLVDEKF 509

  Fly   453 VDGWDDPRFPTVRGIIRRGMTVEGLKEFIIAQGSSKSVVFMNWDKIWAFNKKVIDPIAPRYT-AL 516
            |.||||||..|:..|.|||:....:..||...|.:.|...:...:..:..:|.::...||.. .|
Yeast   510 VRGWDDPRLFTLEAIRRRGVPPGAILSFINTLGVTTSTTNIQVVRFESAVRKYLEDTTPRLMFVL 574

  Fly   517 EKEKRVIVNVAGAKVERIQVSVHPKDESLGKKTVLLGPRIYIDYVDAEALKEGENATFINWGNIL 581
            :..:.|:.|::....|...:...|.....|::||....:.||:..|..
Yeast   575 DPVEVVVDNLSDDYEELATIPYRPGTPEFGERTVPFTNKFYIERSDFS----------------- 622

  Fly   582 IRKVNKDASGNITSVDAALNLENKDFKKTLKLTWLAVEDDPSAYPPTFCVYFDNIISKAVLGKDE 646
                                 ||.|.|:..:||       |:  .|...:...:.:|...|.|||
Yeast   623 ---------------------ENVDDKEFFRLT-------PN--QPVGLIKVSHTVSFKSLEKDE 657

  Fly   647 DFKQFIGHKTRDEVPMLGDPELKKCKKGDIIQLQRRGFFKVDVAYAPPSGYTNVPSPIV------ 705
            ..|....|...|.....|    .|.||.           |..:.:.|.|...|.|..:.
Yeast   658 AGKIIRIHVNYDNKVEEG----SKPKKP-----------KTYIQWVPISSKYNSPLRVTETRVYN 707

  Fly   706 -LF------SIPDGHTKDVPTSGLKVNAPDAKATKKASSPVSSSGQASE-----LDSQISQQGDL 758
             ||      |.|:|..||:        .|:::...|.|....:.|...:     :||..:.:..:
Yeast   708 QLFKSENPSSHPEGFLKDI--------NPESEVVYKESVMEHNFGDVVKNSPWVVDSVKNSEFYV 764

  Fly   759 VRDLKSKKAAK-----------DQIDVAVKKLLALKADYKSATGK 792
            ..|..||:..:           |:.....|.:|......|.||.|
Yeast   765 EEDKDSKEVCRFQAMRVGYFTLDKESTTSKVILNRIVSLKDATSK 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluProRS	NP_524471.2	PLN02907	1..715	CDD:215492	214/795 (27%)
		GST_C_GluProRS_N	76..153	CDD:198342	16/139 (12%)
		tRNA-synt_1c	203..508	CDD:279135	127/313 (41%)
		tRNA-synt_1c_C	510..688	CDD:281883	34/178 (19%)
		WHEP-TRS	748..799	CDD:278865	12/56 (21%)
		WHEP-TRS	821..870	CDD:278865
		WHEP-TRS	894..945	CDD:278865
		WEPRS_RNA	973..1022	CDD:238473
		WHEP-TRS	1050..1100	CDD:278865
		WHEP-TRS	1122..1168	CDD:278865
		PRK08661	1220..1714	CDD:236327
		ProRS_core_arch_euk	1224..1486	CDD:238401
		ProRS_anticodon_zinc	1492..1714	CDD:238439
GLN4	NP_014811.3	tRNA_synt_1c_R1	5..163	CDD:398315	25/169 (15%)
		tRNA_synt_1c_R2	166..244	CDD:398314	16/77 (21%)
		glnS	252..807	CDD:273079	184/624 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810