DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluProRS and GUS1

DIOPT Version :9

Sequence 1:	NP_524471.2	Gene:	GluProRS / 42834	FlyBaseID:	FBgn0005674	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_011269.2	Gene:	GUS1 / 852606	SGDID:	S000003214	Length:	708	Species:	Saccharomyces cerevisiae

Alignment Length:	732	Identity:	314/732 - (42%)
Similarity:	441/732 - (60%)	Gaps:	68/732 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LATAHLINGTVP----VEIVWSKEETSLQFPDNRLLVCHSNNDVLRALARAAPDYKLYGETAI-- 75
            |..|.::|...|    :::|..|:..:.:..|       :..||..         |:..:.|.
Yeast    19 LIAARIVNALAPNSIAIKLVDDKKAPAAKLDD-------ATEDVFN---------KITSKFAAIF 67

  Fly    76 ---ERTQIDHWLSFS---LTCED--DISWALSFLDKSIAPVTYLVAN-KLTIADFALFNEMHSR- 130
               ::.|:..|::.:   |..::  .:|.:|..||..:...|:::.. |.:.||.|.:..:.|.
Yeast    68 DNGDKEQVAKWVNLAQKELVIKNFAKLSQSLETLDSQLNLRTFILGGLKYSAADVACWGALRSNG 132

  Fly   131 -YEFLAAKGIPQHVQRWYDLITAQPLIQKVLQSLPED-AKVKRSPQSSKEQTPAKTGERKQEGKF 193
             ...:....:..:|.|||.|:...|:..:....|.:. .::|:|         |..|::|:..|.
Yeast   133 MCGSIIKNKVDVNVSRWYTLLEMDPIFGEAHDFLSKSLLELKKS---------ANVGKKKETHKA 188

  Fly   194 ---VDLPGAEMGKVVVRFPPEASGYLHIGHAKAALLNQYYALAFQGTLIMRFDDTNPAKETVEFE 255
               :|||.|:||:||.|||||.|||||||||||||||||:|.|::|.||:|||||||:||..||:
Yeast   189 NFEIDLPDAKMGEVVTRFPPEPSGYLHIGHAKAALLNQYFAQAYKGKLIIRFDDTNPSKEKEEFQ 253

  Fly   256 NVILGDLEQLQIKPDVFTHTSNYFDLMLDYCVRLIKESKAYVDDTPPEQMKLEREQRVESANRSN 320
            :.||.||:.|.||.|..|::|:||..|.||||::||:.|||.||||.|:|:.||...|.||.|..
Yeast   254 DSILEDLDLLGIKGDRITYSSDYFQEMYDYCVQMIKDGKAYCDDTPTEKMREERMDGVASARRDR 318

  Fly   321 SVEKNLSLW-EEMVKGSEKGQKYCVRAKIDMSSPNGCMRDPTIYRCKNEPHPRTGTKYKVYPTYD 384
            |||:||.:: |||..|:|:|.|.|||||||..:.|..:|||.||||...||.|||:.:|:|||||
Yeast   319 SVEENLRIFTEEMKNGTEEGLKNCVRAKIDYKALNKTLRDPVIYRCNLTPHHRTGSTWKIYPTYD 383

  Fly   385 FACPIVDAIENVTHTLRTTEYHDRDDQFYWFIDALKLRKPYIWSYSRLNMTNTVLSKRKLTWFVD 449
            |..|||||||.|||.|||.||.||:.|:.|.:.||:|||.:||.::|:|...|:||||||.|.||
Yeast   384 FCVPIVDAIEGVTHALRTIEYRDRNAQYDWMLQALRLRKVHIWDFARINFVRTLLSKRKLQWMVD 448

  Fly   450 SGLVDGWDDPRFPTVRGIIRRGMTVEGLKEFIIAQGSSKSVVFMNWDKIWAFNKKVIDPIAPRYT 514
            ..||..|||||||||||:.|||||||||:.|:::||.|::|:.:.|:.|||||||||||||||:|
Yeast   449 KDLVGNWDDPRFPTVRGVRRRGMTVEGLRNFVLSQGPSRNVINLEWNLIWAFNKKVIDPIAPRHT 513

  Fly   515 ALEKEKRVIVNVAGAKVE-RIQVS-VHPKDESLGKKTVLLGPRIYIDYVDAEALKEGENATFINW 577
            |:....::.:..:.|..| :|::. .|.|:.::|:|.|:....|.:|..||:.:...|..|.::|
Yeast   514 AIVNPVKIHLEGSEAPQEPKIEMKPKHKKNPAVGEKKVIYYKDIVVDKDDADVINVDEEVTLMDW 578

  Fly   578 GNILIRKVNKDASGNITSVDAALNLENKDFKKTL-KLTWLAVEDDPSAYPPTFCVYFDNIISKAV 641
            ||::|.|.|.|.     |:.|.||||. |||||. ||||||   |.....|...|.||::|:|..
Yeast   579 GNVIITKKNDDG-----SMVAKLNLEG-DFKKTKHKLTWLA---DTKDVVPVDLVDFDHLITKDR 634

  Fly   642 LGKDEDFKQFIGHKTRDEVPMLGDPELKKCKKGDIIQLQRRGFFKVDVAYAPPSGYTNVPSPIVL 706
            |.:||.|:.|:..:|......:.|..:|..|.|||||.:|:|::::|.  .|..|     .|.|.
Yeast   635 LEEDESFEDFLTPQTEFHTDAIADLNVKDMKIGDIIQFERKGYYRLDA--LPKDG-----KPYVF 692

  Fly   707 FSIPDGHTKDVPTSGLK 723
            |:||||  |.|...|.|
Yeast   693 FTIPDG--KSVNKYGAK 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluProRS	NP_524471.2	PLN02907	1..715	CDD:215492	310/722 (43%)
		GST_C_GluProRS_N	76..153	CDD:198342	18/84 (21%)
		tRNA-synt_1c	203..508	CDD:279135	188/305 (62%)
		tRNA-synt_1c_C	510..688	CDD:281883	66/180 (37%)
		WHEP-TRS	748..799	CDD:278865
		WHEP-TRS	821..870	CDD:278865
		WHEP-TRS	894..945	CDD:278865
		WEPRS_RNA	973..1022	CDD:238473
		WHEP-TRS	1050..1100	CDD:278865
		WHEP-TRS	1122..1168	CDD:278865
		PRK08661	1220..1714	CDD:236327
		ProRS_core_arch_euk	1224..1486	CDD:238401
		ProRS_anticodon_zinc	1492..1714	CDD:238439
GUS1	NP_011269.2	GST_C_family	72..>128	CDD:413470	12/55 (22%)
GUS1	NP_011269.2	gltX_arch	102..696	CDD:273091	289/618 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346665
Domainoid	1	1.000	395	1.000	Domainoid score	I91
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002386
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1809
TreeFam	0	0.000	Not matched by this tool.
	6	5.740