DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluProRS and Ears2

DIOPT Version :9

Sequence 1:NP_524471.2 Gene:GluProRS / 42834 FlyBaseID:FBgn0005674 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_080416.1 Gene:Ears2 / 67417 MGIID:1914667 Length:523 Species:Mus musculus


Alignment Length:419 Identity:91/419 - (21%)
Similarity:161/419 - (38%) Gaps:111/419 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   185 GER--KQEGKFVDLPGAEMGKVVVRFPPEASGYLHIGHAKAALLNQYYALAFQGTLIMRFDDTNP 247
            |.|  ::|......|||   .|.|||.|..:|:||:|..:.||.|..:|...||:.|:|.:||:.
Mouse    19 GHRVGRREASLGPDPGA---PVRVRFAPSPTGFLHLGGLRTALYNYIFAKKHQGSFILRLEDTDQ 80

  Fly   248 AKETVEFENVILGDLEQLQIKPDVFTH---------TSNYFDLMLDYCVRLIKESKAYVDDTPPE 303
            ::........|...||...|.||....         .|....|.......|::...||.....|:
Mouse    81 SRLVPGAAESIEDMLEWAGIPPDESPRRGGPAGPYCQSQRLALYAQATEALLRSGAAYPCFCLPQ 145

  Fly   304 QMKLEREQRVESAN--RSNSVEKNLSLWEEMVKGSEKGQKYCVRAK------------------- 347
            :::|.:::.:.|..  |.::..:|||       .::..||..|..|                   
Mouse   146 RLELLKKEALRSRQTPRYDNRCRNLS-------QAQVAQKLAVDPKPAIRFRLEEAVPAFQDLVY 203

  Fly   348 ----IDMSSPNGCMRDPTIYRCKNEPHPRTGTKYKVYPTYDFACPIVDAIENVTHTLRTTEYHDR 408
                .:::|..|   ||.|.:...            :|||..||.:.|...:::|.||.:|    
Mouse   204 GWTQHEVASVEG---DPVILKSDG------------FPTYHLACVVDDHHMSISHVLRGSE---- 249

  Fly   409 DDQFYWFIDALK---LRKPYIWSYSR-------LNMTNTVLSKRK---------LTWFVDSGLVD 454
                 |.:...|   |.:...|...|       ||...:.||||:         .|.|:...|:|
Mouse   250 -----WLVSTSKHLLLYQALGWQPPRFAHLPLLLNRDGSKLSKRQGDIFLEHFAATGFLPEALLD 309

  Fly   455 -------GWDDPRFPTVRGIIRRGMTV-EGLKEFIIAQGSSKSVVFMNWDKIWAFN----KKVID 507
                   |:.:.:.         |.|: |.:.:|.:.:.:..|.: ::.:|:..||    ::::.
Mouse   310 IITNCGSGFAENQM---------GRTLPELITQFDLTRITCHSAL-LDLEKLPEFNRLHLRRLVS 364

  Fly   508 PIAPRYTALEKEKRVIVNVAGAKVERIQV 536
            ....|...:||.:.::....|::::...|
Mouse   365 SETQRPQLVEKLQGLVKEAFGSELQNKDV 393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluProRSNP_524471.2 PLN02907 1..715 CDD:215492 91/419 (22%)
GST_C_GluProRS_N 76..153 CDD:198342
tRNA-synt_1c 203..508 CDD:279135 80/369 (22%)
tRNA-synt_1c_C 510..688 CDD:281883 5/27 (19%)
WHEP-TRS 748..799 CDD:278865
WHEP-TRS 821..870 CDD:278865
WHEP-TRS 894..945 CDD:278865
WEPRS_RNA 973..1022 CDD:238473
WHEP-TRS 1050..1100 CDD:278865
WHEP-TRS 1122..1168 CDD:278865
PRK08661 1220..1714 CDD:236327
ProRS_core_arch_euk 1224..1486 CDD:238401
ProRS_anticodon_zinc 1492..1714 CDD:238439
Ears2NP_080416.1 gltX 36..521 CDD:234953 85/399 (21%)
GluRS_core 37..361 CDD:173905 80/364 (22%)
Glutamate binding. /evidence=ECO:0000250 40..42 1/1 (100%)
'HIGH' region 45..53 3/7 (43%)
Glutamate binding. /evidence=ECO:0000250 228..232 1/3 (33%)
'KMSKS' region 284..288 2/3 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0008
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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