DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluProRS and ears-1

DIOPT Version :9

Sequence 1:	NP_524471.2	Gene:	GluProRS / 42834	FlyBaseID:	FBgn0005674	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_001366832.1	Gene:	ears-1 / 172904	WormBaseID:	WBGene00001337	Length:	1149	Species:	Caenorhabditis elegans

Alignment Length:	1224	Identity:	573/1224 - (46%)
Similarity:	738/1224 - (60%)	Gaps:	118/1224 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKANLNNPPISGLATAHLINGTVPVEIVWS-KEETSLQFPDNRLLVCHSNN-DVLRALARA--AP 65
            ||||...||.:.:........::...:.:| |::.:|.. |..||   ||: ::.|.:|::  |.
Worm     9 LKANREQPPYASILALAASGFSLEKSVQFSEKQQLALNL-DGELL---SNDVEIARIIAQSTDAA 69

  Fly    66 DYKLYGETAIERTQIDHWLSFSLTCEDDISWALSFLDKSIAPVTYLVANKLTIADFALFNEMHSR 130
            | .|.|.:.|:...:|...:|.........::| .|.|...  |.::.|.||:||||:|:..|:.
Worm    70 D-SLLGSSIIDFAVVDDLTNFIADAVTKNDYSL-LLGKDFP--TKILDNSLTVADFAIFSVAHNN 130

  Fly   131 YEFLAAK--GIPQHVQRWYDLITAQPLIQKVLQSLPEDA---------KVKRSPQSSKEQTPAKT 184
            .: |.||  ||                |.|||:. |..|         |...:|.::     |.|
Worm   131 PQ-LKAKFSGI----------------IDKVLKE-PTLAAAHNFVGLYKSAAAPTAT-----AST 172

  Fly   185 G--ERKQEGKFVDLPGAEMGKVVVRFPPEASGYLHIGHAKAALLNQYYALAFQGTLIMRFDDTNP 247
            |  ::|.|||||:|||||.|||||||||||||||||||||||||||||..||:|.||||||||||
Worm   173 GKEKKKDEGKFVELPGAEKGKVVVRFPPEASGYLHIGHAKAALLNQYYQQAFEGQLIMRFDDTNP 237

  Fly   248 AKETVEFENVILGDLEQLQIKPDVFTHTSNYFDLMLDYCVRLIKESKAYVDDTPPEQMKLEREQR 312
            |||...||:||..||..|.|.||.:||:|::|:::|..|.:|:||.||:||||..|.|:.|||||
Worm   238 AKENAHFEHVIKEDLSMLNIVPDRWTHSSDHFEMLLTMCEKLLKEGKAFVDDTDTETMRNEREQR 302

  Fly   313 VESANRSNSVEKNLSLWEEMVKGSEKGQKYCVRAKIDMSSPNGCMRDPTIYRCKNEPHPRTGTKY 377
            .:|.||||:.||||.|||||.|||.||...|||.||||.|.||.||||||||||.|.|.|||.||
Worm   303 QDSRNRSNTPEKNLQLWEEMKKGSPKGLTCCVRMKIDMKSNNGAMRDPTIYRCKPEEHVRTGLKY 367

  Fly   378 KVYPTYDFACPIVDAIENVTHTLRTTEYHDRDDQFYWFIDALKLRKPYIWSYSRLNMTNTVLSKR 442
            ||||||||.|||||::|.|||.||||||||||||:|:..|||.||:|:||.|:||||||||:|||
Worm   368 KVYPTYDFTCPIVDSVEGVTHALRTTEYHDRDDQYYFICDALGLRRPHIWEYARLNMTNTVMSKR 432

  Fly   443 KLTWFVDSGLVDGWDDPRFPTVRGIIRRGMTVEGLKEFIIAQGSSKSVVFMNWDKIWAFNKKVID 507
            |||||||.|.|:||||||.|||||::|||:||||||:||:|||.|:|||.|.|||||||||||||
Worm   433 KLTWFVDEGHVEGWDDPRLPTVRGVMRRGLTVEGLKQFIVAQGGSRSVVMMEWDKIWAFNKKVID 497

  Fly   508 PIAPRYTALEKEKRVI-VNVAGA-KVERIQVSVHPKDESLGKKTVLLGPRIYIDYVDAEALKEGE 570
            |:|||||||:....:: :.:..: ..:...||:|||:..:|.|.|..|.::.::.|||.||||||
Worm   498 PVAPRYTALDSTSPLVSIELTDSISDDTSNVSLHPKNAEIGSKDVHKGKKLLLEQVDAAALKEGE 562

  Fly   571 NATFINWGNILIRKVNKDASGNITSVDAALNLENKDFKKTLKLTWLA-VEDDPSAYPPTFCVYFD 634
            ..||:|||||.|.|:.|..: .||.:.|.|.|:|.|:|||.|:|||. |:.:.....|.....:|
Worm   563 IVTFVNWGNIKIGKIEKKGA-VITKISATLQLDNTDYKKTTKVTWLGDVKAEAGKTIPVVTADYD 626

  Fly   635 NIISKAVLGKDEDFKQFIGHKTRDEVPMLGDPELKKCKKGDIIQLQRRGFFKVDVAYAPPSGYTN 699
            :|||||::|||||:||||...:.....|:|:|.:|..|||||||:||:||:.||..|.|.|..:.
Worm   627 HIISKAIIGKDEDWKQFINFDSVHYTKMVGEPAIKNVKKGDIIQIQRKGFYIVDQPYNPKSELSG 691

  Fly   700 VPSPIVLFSIPDGHT---KDVPTSGLKVNAPDAKATKKASSPVSSSGQASELDSQISQQGDLVRD 761
            |.:|::|.:||||||   .:.|..|..|:|        |:|  |....|.:|.:.|.|||.:|||
Worm   692 VETPLLLIAIPDGHTGKEAEKPPKGAPVSA--------AAS--SGGSDALQLYNSIEQQGGIVRD 746

  Fly   762 LKSKKAAKDQIDVAVKKLLALKADYKSATGKDWKPGQTSASSAPVPAA-SSSSANDAVSVNASIV 825
            ||:|.|.......|:.|||.||..||..||.|.|||  :..|||.|.. |||.:|.|:::...|.
Worm   747 LKTKDAKSQATKDAIAKLLDLKKKYKELTGSDHKPG--APPSAPAPTTPSSSESNSALNIYNLIE 809

  Fly   826 KQGDLVRDLKGKKASKPEIDAAVKTLLELKAQYKTLTGQDWKPGTVPTTAAPSASA-APSVGVND 889
            .||.|||:||||.|.......|:..|||||.|||.::|.|.|||..|..:..||.| ||:.|..:
Worm   810 AQGLLVRELKGKDAKSQATKDAIAKLLELKKQYKEVSGSDHKPGVPPAASVASAPAPAPAAGSTN 874

  Fly   890 SVAQILSQITAQGDKVRELKSAKA-DKATVDAAVKTLLSLKADYKAATGSDWKPGTTAPAPAAAP 953
            :: .|..||.:||..|||||...| .:||.||..| ||:||..||..||||.|||.   .|.:||
Worm   875 AL-DIYHQIESQGALVRELKGKDAKSQATKDAIAK-LLALKKQYKEVTGSDHKPGV---VPVSAP 934

  Fly   954 VKVKQEKNPDPASVLTVNTLLNKIAQQGDKIRQLKSAKSEKSLVEAEVKLLLALKTDYKSLTGQE 1018
            .         |..:.....:..:|..||..:|.||:..|:....:..:..||.||.:||.:||.:
Worm   935 A---------PTPLAGGADIAGQIEAQGVLVRDLKNKDSKSQETKDAIAKLLELKKNYKEVTGSD 990

  Fly  1019 WKPG---TVAPAPTTVNVIDLTGGDSGSDVGSVLSK-IQAQGDKIRKLKSEKAAKNVIDPEVKTL 1079
            :|||   ..|||..||....::|||:       ||| |..|...:|:||.:.|........:..|
Worm   991 YKPGPAPAAAPAKVTVPAPSVSGGDT-------LSKQIDDQALLVRELKMKDAKSQETKDAIAKL 1048

  Fly  1080 LALKGEYKTLSGKDWTPDAKSEPAVVKKEASPVSMASPAKDE--LTQEINAQGEKVRAAKG-NKA 1141
            |.||.:||..:|.|:.|    .||.:...|:.....:||.||  |.:||..||..||.||. :..
Worm  1049 LQLKKQYKDATGSDYKP----APAQLAASAAAAPAPAPAFDEAALLKEIEEQGAVVRDAKSKDPK 1109

  Fly  1142 AKEVIDAEVAKLLALKAKYKEVTGTDFPVAGRGGGGGGGSAKKAPKEAQPKPAK 1195
            :::..|| :.|||||||.:|:.||.|||               ||..||.|..|
Worm  1110 SQDSADA-INKLLALKANFKKATGKDFP---------------APSNAQSKKGK 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluProRS	NP_524471.2	PLN02907	1..715	CDD:215492	384/732 (52%)
		GST_C_GluProRS_N	76..153	CDD:198342	20/78 (26%)
		tRNA-synt_1c	203..508	CDD:279135	223/304 (73%)
		tRNA-synt_1c_C	510..688	CDD:281883	81/180 (45%)
		WHEP-TRS	748..799	CDD:278865	26/50 (52%)
		WHEP-TRS	821..870	CDD:278865	24/48 (50%)
		WHEP-TRS	894..945	CDD:278865	29/51 (57%)
		WEPRS_RNA	973..1022	CDD:238473	16/48 (33%)
		WHEP-TRS	1050..1100	CDD:278865	17/50 (34%)
		WHEP-TRS	1122..1168	CDD:278865	21/46 (46%)
		PRK08661	1220..1714	CDD:236327
		ProRS_core_arch_euk	1224..1486	CDD:238401
		ProRS_anticodon_zinc	1492..1714	CDD:238439
ears-1	NP_001366832.1	PLN02907	6..708	CDD:215492	384/730 (53%)
		S15_NS1_EPRS_RNA-bind	733..782	CDD:412325	24/48 (50%)
		WEPRS_RNA	804..853	CDD:238473	23/48 (48%)
		WEPRS_RNA	878..927	CDD:238473	27/49 (55%)
		WEPRS_RNA	948..994	CDD:238473	16/45 (36%)
		WEPRS_RNA	1017..1064	CDD:238473	17/46 (37%)
		WEPRS_RNA	1089..1138	CDD:238473	24/64 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167608
Domainoid	1	1.000	475	1.000	Domainoid score	I209
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H111277
Inparanoid	1	1.050	930	1.000	Inparanoid score	I177
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111937at33208
OrthoFinder	1	1.000	-	-		FOG0002386
OrthoInspector	1	1.000	-	-		oto18703
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43382
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1809
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900