DRSC/TRiP Functional Genomics Resources

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Protein Alignment GluProRS and EARS2

DIOPT Version :9

Sequence 1:NP_524471.2 Gene:GluProRS / 42834 FlyBaseID:FBgn0005674 Length:1714 Species:Drosophila melanogaster
Sequence 2:NP_001295140.1 Gene:EARS2 / 124454 HGNCID:29419 Length:534 Species:Homo sapiens


Alignment Length:467 Identity:103/467 - (22%)
Similarity:189/467 - (40%) Gaps:128/467 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 LIQKVLQSLPEDAKVKRSPQSSKEQTPAKTGE--RKQEGKFVDLPGAEMGKVV-VRFPPEASGYL 216
            |::::||               :|:..|.:|.  .::|...    |.:.|..| |||.|..:|:|
Human     4 LLRRLLQ---------------RERPSAASGRPVGRREANL----GTDAGVAVRVRFAPSPTGFL 49

  Fly   217 HIGHAKAALLNQYYALAFQGTLIMRFDDTNPAKETVEFENVILGDLEQLQ-------IKPDVFT- 273
            |:|..:.||.|..:|..:||:.|:|.:||:..:       |:.|..|.::       |.||... 
Human    50 HLGGLRTALYNYIFAKKYQGSFILRLEDTDQTR-------VVPGAAENIEDMLEWAGIPPDESPR 107

  Fly   274 --------HTSNYFDLMLDYCVRLIKESKAYVDDTPPEQMKLEREQ--RVESANRSNSVEKNLSL 328
                    ..|...:|.......|:|...||.....|::::|.:::  |.....|.::..:|:| 
Human   108 RGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRYDNRCRNMS- 171

  Fly   329 WEEMVKGSEKGQKYCVRAKIDMSSP------NGCMR--------DPTIYRCKNEPHPRTGTKYKV 379
            .|::.:...|..|..:|.:::...|      .|..|        ||.|.:...            
Human   172 QEQVAQKLAKDPKPAIRFRLEQVVPAFQDLVYGWNRHEVASVEGDPVIMKSDG------------ 224

  Fly   380 YPTYDFACPIVDAIENVTHTLRTTEYHDRDDQFYWFIDALK---LRKPYIWSYSR-------LNM 434
            :|||..||.:.|....::|.||.:|         |.:...|   |.:...|....       ||.
Human   225 FPTYHLACVVDDHHMGISHVLRGSE---------WLVSTAKHLLLYQALGWQPPHFAHLPLLLNR 280

  Fly   435 TNTVLSKRKLTWFVDSGLVDGWDDPRFP-TVRGII----------RRGMTV-EGLKEFIIAQGSS 487
            ..:.||||:...|::....||:    .| ::..||          :.|.|: |.:.:|.:.|.:.
Human   281 DGSKLSKRQGDVFLEHFAADGF----LPDSLLDIITNCGSGFAENQMGRTLPELITQFNLTQVTC 341

  Fly   488 KSVVFMNWDKIWAFNKKVIDPIAPRYTALEKEKRVIVNVAGAKVERIQVSVHPKDESLG---KKT 549
            .|.: ::.:|:..||:..:.    |..:.|.::|.:|.       ::||.|   :|:.|   :..
Human   342 HSAL-LDLEKLPEFNRLHLQ----RLVSNESQRRQLVG-------KLQVLV---EEAFGCQLQNR 391

  Fly   550 VLLGPRIYIDYV 561
            .:|.| :|::.:
Human   392 DVLNP-VYVERI 402

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GluProRSNP_524471.2 PLN02907 1..715 CDD:215492 103/467 (22%)
GST_C_GluProRS_N 76..153 CDD:198342
tRNA-synt_1c 203..508 CDD:279135 82/359 (23%)
tRNA-synt_1c_C 510..688 CDD:281883 12/55 (22%)
WHEP-TRS 748..799 CDD:278865
WHEP-TRS 821..870 CDD:278865
WHEP-TRS 894..945 CDD:278865
WEPRS_RNA 973..1022 CDD:238473
WHEP-TRS 1050..1100 CDD:278865
WHEP-TRS 1122..1168 CDD:278865
PRK08661 1220..1714 CDD:236327
ProRS_core_arch_euk 1224..1486 CDD:238401
ProRS_anticodon_zinc 1492..1714 CDD:238439
EARS2NP_001295140.1 GluRS_core 36..361 CDD:173905 82/362 (23%)
gltX 37..508 CDD:234953 94/415 (23%)
Glutamate binding. /evidence=ECO:0000250 40..42 1/1 (100%)
'HIGH' region 45..53 3/7 (43%)
Glutamate binding. /evidence=ECO:0000250 228..232 1/3 (33%)
'KMSKS' region 284..288 2/3 (67%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0008
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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