DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluProRS and Eprs

DIOPT Version :9

Sequence 1:	NP_524471.2	Gene:	GluProRS / 42834	FlyBaseID:	FBgn0005674	Length:	1714	Species:	Drosophila melanogaster
Sequence 2:	NP_001344403.1	Gene:	Eprs / 107508	MGIID:	97838	Length:	1519	Species:	Mus musculus

Alignment Length:	1750	Identity:	885/1750 - (50%)
Similarity:	1095/1750 - (62%)	Gaps:	276/1750 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LKANLNNPPISGLATAHLINGTVPVEIVWSKE-----ETSLQFPDNRLLVCHSNNDVLRALARAA 64
            |..|..|||:..|.....:.|.|.:.:...||     ..::.|.|        .|.:||.|||.|
Mouse     6 LTVNAGNPPLEALLAVEHVKGDVSISVEEGKENLLRVSETVAFTD--------VNSILRYLARIA 62

  Fly    65 PDYKLYGETAIERTQIDHWLSFSLT----CEDDISWALSFLDKSIAPVTYLVANKLTIADFALFN 125
            ....|||...:|.|:|||||.||.|    | |.::.|::.|:..::..||||.|.||:||..::.
Mouse    63 TTSGLYGTNLMEHTEIDHWLEFSATKLSSC-DRLTSAINELNHCLSLRTYLVGNSLTLADLCVWA 126

  Fly   126 EMHSR---YEFLAAKGIPQHVQRWYDLITAQPLIQKVLQSLPEDAKVKRSPQSSKEQTPAKTGER 187
            .:...   .|.|.......||:||:..:.||...:.|         ..:...|....|.|.  ::
Mouse   127 TLKGSAAWQEHLKQNKTLVHVKRWFGFLEAQQAFRSV---------GTKWDVSGNRATVAP--DK 180

  Fly   188 KQE-GKFVDLPGAEMGKVVVRFPPEASGYLHIGHAKAALLNQYYALAFQGTLIMRFDDTNPAKET 251
            ||: ||||:|||||||||.|||||||||||||||||||||||:|.:.|:|.||||||||||.||.
Mouse   181 KQDVGKFVELPGAEMGKVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEK 245

  Fly   252 VEFENVILGDLEQLQIKPDVFTHTSNYFDLMLDYCVRLIKESKAYVDDTPPEQMKLEREQRVESA 316
            .:||.|||.|:..|.||||.||:||::|:.::.|..:||:|.||||||||.||||.|||||.||.
Mouse   246 EDFEKVILEDVAMLHIKPDQFTYTSDHFETIMKYAEKLIQEGKAYVDDTPAEQMKAEREQRTESK 310

  Fly   317 NRSNSVEKNLSLWEEMVKGSEKGQKYCVRAKIDMSSPNGCMRDPTIYRCKNEPHPRTGTKYKVYP 381
            :|.|||||||.:||||.|||:.||..|:||||||||.||||||||:||||.:||||||.||.|||
Mouse   311 HRKNSVEKNLQMWEEMKKGSQFGQSCCLRAKIDMSSNNGCMRDPTLYRCKIQPHPRTGNKYNVYP 375

  Fly   382 TYDFACPIVDAIENVTHTLRTTEYHDRDDQFYWFIDALKLRKPYIWSYSRLNMTNTVLSKRKLTW 446
            ||||||||||:||.|||.||||||||||:||||.|:||.:||||||.|||||:.|||||||||||
Mouse   376 TYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPYIWEYSRLNLNNTVLSKRKLTW 440

  Fly   447 FVDSGLVDGWDDPRFPTVRGIIRRGMTVEGLKEFIIAQGSSKSVVFMNWDKIWAFN-------KK 504
            ||:.||||||||||||||||::||||||||||:||.|||||:|||.|.||||||||       ||
Mouse   441 FVNEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRSVVNMEWDKIWAFNKKLRALCKK 505

  Fly   505 VIDPIAPRYTALEKEKRVIVNVAGAKVERIQVSVHPKDESLGKKTVLLGPRIYIDYVDAEALKEG 569
            ||||:||||.||.|::.|.|||..|:.|..:|:.|||:..:|.|.|...|:::|:..|||...||
Mouse   506 VIDPVAPRYVALLKKEVVPVNVLDAQEEMKEVARHPKNPDVGLKPVWYSPKVFIEGADAETFSEG 570

  Fly   570 ENATFINWGNILIRKVNKDASGNITSVDAALNLENKDFKKTLKLTWLAVEDDPSAYPPTFCVYFD 634
            |..||||||||.|.|::|:|.|.|||:||.|||||||:|||.|:|||| |...:...|..||.::
Mouse   571 EMVTFINWGNINITKIHKNADGKITSLDAKLNLENKDYKKTTKITWLA-ESTHALSIPAVCVTYE 634

  Fly   635 NIISKAVLGKDEDFKQFIGHKTRDEVPMLGDPELKKCKKGDIIQLQRRGFFKVDVAYAPPSGYTN 699
            ::|:|.||||||||||:|...::.|..|||||.||..||||||||||||||..|..|.|.|.|:.
Mouse   635 HLITKPVLGKDEDFKQYINKDSKHEELMLGDPCLKDLKKGDIIQLQRRGFFICDQPYEPVSPYSC 699

  Fly   700 VPSPIVLFSIPDGHTKDVPTSGLK------------VNAPDAKATKKASSPVSSSGQASELDSQI 752
            ..:|.:|..|||||||::||||.|            .:||..:.....||..:::..:|.|.|::
Mouse   700 REAPCILIYIPDGHTKEMPTSGSKEKTKVEISKKETSSAPKERPAPAVSSTCATAEDSSVLYSRV 764

  Fly   753 SQQGDLVRDLKSKKAAKDQIDVAVKKLLALKADYKSATGKDWKPGQTSASSA-PVPAASSSSAND 816
            :.|||:||:||:|||.|:.||.|||:||.|||:||..||:::|||..||::. .|...|||:..:
Mouse   765 AVQGDVVRELKAKKAPKEDIDAAVKQLLTLKAEYKEKTGQEYKPGNPSAAAVQTVSTKSSSNTVE 829

  Fly   817 AVSVNASIVKQGDLVRDLKGKKASKPEIDAAVKTLLELKAQYKTLTGQDWKPGTVPTT----AAP 877
            :.|:...:..||::||.||.:||.|.::..||:.||.|||:||..||:|:.||..|.:    :.|
Mouse   830 STSLYNKVAAQGEVVRKLKAEKAPKAKVTEAVECLLSLKAEYKEKTGKDYVPGQPPASQNSHSNP 894

  Fly   878 SASAAPSVGVNDSVAQIL-SQITAQGDKVRELKSAKADKATVDAAVKTLLSLKADYKAATGSDWK 941
            .::|.|: |.....|::| .::..||:.||:||:.||.|..||:||:.||.|||.||:.||.::|
Mouse   895 VSNAQPA-GAEKPEAKVLFDRVACQGEVVRKLKAEKASKDQVDSAVQELLQLKAQYKSLTGIEYK 958

  Fly   942 PGTTAPAPAAAPVKVKQEKNPDPASVLTVNTLLNKIAQQGDKIRQLKSAKSEKSLVEAEVKLLLA 1006
            |.:...                              |:..||.::.|..||||.
Mouse   959 PVSATG------------------------------AEDKDKKKKEKENKSEKQ----------- 982

  Fly  1007 LKTDYKSLTGQEWKPGTVAPAPTTVNVIDLTGGDSGSDVGSVLSKIQAQGDKIRKLKSEKAAKNV 1071
                                                       :|.|.|.|
Mouse   983 -------------------------------------------NKPQKQND-------------- 990

  Fly  1072 IDPEVKTLLALKGEYKTLSGKDWTPDAKSEPAVVKKEASPVSMASPAKDELTQEINAQGEKVRAA 1136
                        |:     |||   .:||:
Mouse   991 ------------GQ-----GKD---SSKSQ----------------------------------- 1000

  Fly  1137 KGNKAAKEVIDAEVAKLLALKAKYKEVTGTDFPVAGRGGGGGGGSAKKAPKEAQPKPAKPVKKEP 1201
                                               |.|...||....:.|
Mouse  1001 -----------------------------------GSGLSSGGAGEGQGP--------------- 1015

  Fly  1202 AADASGAVKKQTRLGLEATKEDNLPDWYSQVITKGEMIEYYDVSGCYILRQWSFAIWKAIKTWFD 1266
                    ||||||||||.||:||.:||||||||.|||||||||||||||.||::||::||.:||
Mouse  1016 --------KKQTRLGLEAKKEENLAEWYSQVITKSEMIEYYDVSGCYILRPWSYSIWESIKDFFD 1072

  Fly  1267 AEITRMGVKECYFPIFVSKAVLEKEKTHIADFAPEVAWVTKSGDSDLAEPIAVRPTSETVMYPAY 1331
            |||.::||:.||||||||:|.|||||.||.||||||||||:||.::||||||:||||||||||||
Mouse  1073 AEIKKLGVENCYFPIFVSQAALEKEKNHIEDFAPEVAWVTRSGKTELAEPIAIRPTSETVMYPAY 1137

  Fly  1332 AKWVQSYRDLPIRLNQWNNVVRWEFKQPTPFLRTREFLWQEGHTAFADKEEAAKEVLDILDLYAL 1396
            ||||||:||||:|||||.||||||||.|.||||||||||||||:|||..||||.|||.||:|||.
Mouse  1138 AKWVQSHRDLPVRLNQWCNVVRWEFKHPQPFLRTREFLWQEGHSAFATFEEAADEVLQILELYAR 1202

  Fly  1397 VYTHLLAIPVVKGRKTEKEKFAGGDYTTTVEAFISASGRAIQGATSHHLGQNFSKMFEIVYEDPE 1461
            ||..|||||||:|||||||||||||||||:||||||||||||||||||||||||||.|||:|||:
Mouse  1203 VYEELLAIPVVRGRKTEKEKFAGGDYTTTIEAFISASGRAIQGATSHHLGQNFSKMCEIVFEDPK 1267

  Fly  1462 TQ-QKKYVYQNSWGITTRTIGVMIMVHADNQGLVLPPHVACIQAIVVPCGITVNTKDDERAQLLD 1525
            |. :|::.||.|||:||||||||:|||.||.||||||.||.:|.:|:|||||....:::|..|:.
Mouse  1268 TPGEKQFAYQCSWGLTTRTIGVMVMVHGDNMGLVLPPRVASVQVVVIPCGITNALSEEDREALMA 1332

  Fly  1526 ACKALEKRLVGGGVRCEGDYRDNYSPGWKFNHWELKGVPLRLEVGPKDLKAQQLVAVRRDTVEKI 1590
            .|....:||:|..:|...|.|||||||||||||||||||:||||||:|:|:.|.|||||||.||:
Mouse  1333 KCNEYRRRLLGANIRVRVDLRDNYSPGWKFNHWELKGVPVRLEVGPRDMKSCQFVAVRRDTGEKL 1397

  Fly  1591 TIPLADVEKKIPALLETIHESMLNKAQEDMTSHTKKVTNWTDFCGFLEQKNILLAPFCGEISCED 1655
            ||...:.|.|:..:||.|..::..:|.||:.:|........||...|:...:...||||||.|||
Mouse  1398 TIAEKEAEAKLEKVLEDIQLNLFTRASEDLKTHMVVSNTLEDFQKVLDAGKVAQIPFCGEIDCED 1462

  Fly  1656 KIKADSARGEEAEPGAPAMGAKSLCIPFDQPAPIAASDKCINPSCTNKP-KFYTLFGRSY 1714
            .||..:||.::.|||||:||||||||||:....:.....|:   |...| ||||||||||
Mouse  1463 WIKKMTARDQDVEPGAPSMGAKSLCIPFNPLCELQPGAMCV---CGKNPAKFYTLFGRSY 1519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluProRS	NP_524471.2	PLN02907	1..715	CDD:215492	417/729 (57%)
		GST_C_GluProRS_N	76..153	CDD:198342	29/83 (35%)
		tRNA-synt_1c	203..508	CDD:279135	233/311 (75%)
		tRNA-synt_1c_C	510..688	CDD:281883	100/177 (56%)
		WHEP-TRS	748..799	CDD:278865	30/50 (60%)
		WHEP-TRS	821..870	CDD:278865	22/48 (46%)
		WHEP-TRS	894..945	CDD:278865	25/51 (49%)
		WEPRS_RNA	973..1022	CDD:238473	8/48 (17%)
		WHEP-TRS	1050..1100	CDD:278865	8/49 (16%)
		WHEP-TRS	1122..1168	CDD:278865	0/45 (0%)
		PRK08661	1220..1714	CDD:236327	330/495 (67%)
		ProRS_core_arch_euk	1224..1486	CDD:238401	210/262 (80%)
		ProRS_anticodon_zinc	1492..1714	CDD:238439	113/222 (51%)
Eprs	NP_001344403.1	GlnS	6..718	CDD:332033	419/732 (57%)
		'HIGH' region	204..214		9/9 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..315		14/20 (70%)
		'KMSKS' region	432..436		3/3 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	716..749		7/32 (22%)
		WEPRS_RNA	760..809	CDD:238473	28/48 (58%)
		3 X 57 AA approximate repeats	767..963		89/196 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	802..826		10/23 (43%)
		WEPRS_RNA	833..882	CDD:238473	21/48 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..905		9/29 (31%)
		WEPRS_RNA	911..959	CDD:238473	23/47 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	963..1018		24/265 (9%)
		Proline--tRNA ligase	1014..1519		341/530 (64%)
		PRK08661	1026..1519	CDD:236327	330/495 (67%)
		L-proline binding. /evidence=ECO:0000250\|UniProtKB:P07814	1128..1130		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850470
Domainoid	1	1.000	500	1.000	Domainoid score	I346
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	972	1.000	Inparanoid score	I319
Isobase	1	0.950	-	0	Normalized mean entropy	S1284
OMA	1	1.010	-	-		QHG52536
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002386
OrthoInspector	1	1.000	-	-		oto93035
orthoMCL	1	0.900	-	-		OOG6_100749
Panther	1	1.100	-	-	LDO	PTHR43382
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1877
SonicParanoid	1	1.000	-	-		X1809
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740