DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12268 and LYS2

DIOPT Version :9

Sequence 1:	NP_001247272.1	Gene:	CG12268 / 42833	FlyBaseID:	FBgn0039131	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_009673.1	Gene:	LYS2 / 852412	SGDID:	S000000319	Length:	1392	Species:	Saccharomyces cerevisiae

Alignment Length:	294	Identity:	69/294 - (23%)
Similarity:	114/294 - (38%)	Gaps:	73/294 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 ILITGATGFMGKVLVEKLL-RSCADLNV-IYLLIRTKKGVDPSVRKEQYFKCVIFGKLLEKNPGI 86
            :.:||.|||:|..::..|| ||..:.:. ::..:|.|.......|.::  ..:.:|...||   .
Yeast   973 VFVTGVTGFLGSYILADLLGRSPKNYSFKVFAHVRAKDEEAAFARLQK--AGITYGTWNEK---F 1032

  Fly    87 VDKVRVVKGDLLEPDLGLSANDTNTLASNVEVVFHCAANVRFDQPLRPMVMMNVVGTLKVLRLAE 151
            ...::||.|||.:...|||......||:.|:::.|..|.|.:..|...:...||:.|:.|:.||
Yeast  1033 ASNIKVVLGDLSKSQFGLSDEKWMDLANTVDIIIHNGALVHWVYPYAKLRDPNVISTINVMSLA- 1096

  Fly   152 KMSQLQALVHVSTSYCQCNESVLEERAYPAPQNP--FSIIEMVETMDDEALAEITPKLL------ 208
                                         |...|  |..:....|:|.|....::.||:
Yeast  1097 -----------------------------AVGKPKFFDFVSSTSTLDTEYYFNLSDKLVSEGKPG 1132

  Fly   209 -----------NGLPNTYAYSKALSEDLICRYNNK-LPIIITRPSIVTAAIHEPLPGWIEGVNGP 261
                       :||...|..||..:|.:|.|...: |...|.||..||.|          ..||.
Yeast  1133 ILESDDLMNSASGLTGGYGQSKWAAEYIIRRAGERGLRGCIVRPGYVTGA----------SANGS 1187

  Fly   262 TG---LMIGAARGVIRSMHCNPDYASTV--IPVD 290
            :.   .::...:|.:: :...||..::|  :|||
Yeast  1188 SNTDDFLLRFLKGSVQ-LGKIPDIENSVNMVPVD 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12268	NP_001247272.1	PLN02996	12..463	CDD:215538	69/294 (23%)
		FAR-N_SDR_e	22..347	CDD:187547	69/294 (23%)
		FAR_C	372..463	CDD:176924
LYS2	NP_009673.1	alpha_am_amid	7..1379	CDD:274582	69/294 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I2873
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.712175	Normalized mean entropy	S3219
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860