DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12268 and FAR2

DIOPT Version :9

Sequence 1:	NP_001247272.1	Gene:	CG12268 / 42833	FlyBaseID:	FBgn0039131	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	XP_011519049.1	Gene:	FAR2 / 55711	HGNCID:	25531	Length:	535	Species:	Homo sapiens

Alignment Length:	531	Identity:	182/531 - (34%)
Similarity:	282/531 - (53%)	Gaps:	41/531 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SDIAKFYANKTILITGATGFMGKVLVEKLLRSCADLNVIYLLIRTKKGVDPSVRKEQYFKCVIFG 77
            |.||.||..|:|||||||||:||||:|||.|:..||.|||:|:|.|.|.....|..|.....:|.
Human    22 STIAAFYGGKSILITGATGFLGKVLMEKLFRTSPDLKVIYILVRPKAGQTLQQRVFQILDSKLFE 86

  Fly    78 KLLEKNPGIVDKVRVVKGDLLEPDLGLSANDTNTLASNVEVVFHCAANVRFDQPLRPMVMMNVVG 142
            |:.|..|.:.:|:|.:..||.:.|..:|..|...|.|...::|||||.||||..||..|.:||..
Human    87 KVKEVCPNVHEKIRAIYADLNQNDFAISKEDMQELLSCTNIIFHCAATVRFDDTLRHAVQLNVTA 151

  Fly   143 TLKVLRLAEKMSQLQALVHVSTSYCQCNESVLEERAYPAPQNPFSIIEMVETMDDEALAEITPKL 207
            |.::|.:|.:|.:|:|.:|:||:|..||...::|..||.|..|..||:.:|.:||..:.||||||
Human   152 TRQLLLMASQMPKLEAFIHISTAYSNCNLKHIDEVIYPCPVEPKKIIDSLEWLDDAIIDEITPKL 216

  Fly   208 LNGLPNTYAYSKALSEDLICRYNNKLPIIITRPSIVTAAIHEPLPGWIEGVNGPTGLMIGAARGV 272
            :...||.|.|:|||.|.::.:.:..|.|.|.|||||.|...||.|||::.:|||.|::|...:|.
Human   217 IRDWPNIYTYTKALGEMVVQQESRNLNIAIIRPSIVGATWQEPFPGWVDNINGPNGIIIATGKGF 281

  Fly   273 IRSMHCNPDYASTVIPVDKAINGMILCGY----QRGKASQ----EKGNKQTGVEFCNLCISSKAL 329
            :|::...|...:.|||||..:|.|:..|:    .|.|::.    ..||...    ||
Human   282 LRAIKATPMAVADVIPVDTVVNLMLAVGWYTAVHRPKSTLVYHITSGNMNP----CN-------- 334

  Fly   330 MSWG----DSIETGRRFFYETPLSFALWYPGGSIKKNYYHHLFCVIFFHYLPAYFIDFWLLVFGQ 390
              |.    ..:.|..:..:|.|..    .|..:...|.:...:.....|..||...|.:|.:.|:
Human   335 --WHKMGVQVLATFEKIPFERPFR----RPNANFTSNSFTSQYWNAVSHRAPAIIYDCYLRLTGR 393

  Fly   391 KPFLLNVQRKVSMGLKLLQYYTTKRWEFRNERFQEMSSQLSLLDQDLFDTSVGQVNWETYISNYI 455
            ||.:..:..::...:.:|:|:..:.||:.....:.:.|:||..||.:|:..|.|:||..||.||:
Human   394 KPRMTKLMNRLLRTVSMLEYFINRSWEWSTYNTEMLMSELSPEDQRVFNFDVRQLNWLEYIENYV 458

  Fly   456 VGMRTYILGESEDTLPQARKVLRRLYILDWVSKVLFFSLSFWFL----------WTHLDGFVERS 510
            :|::.|:|.|....:|:|::.|:||..:.::.....|.:::..|          |..:..|..:.
Human   459 LGVKKYLLKEDMAGIPKAKQRLKRLRNIHYLFNTALFLIAWRLLIARSQMARNVWFFIVSFCYKF 523

  Fly   511 DAFIRSSLSTI 521
            .::.|:| ||:
Human   524 LSYFRAS-STL 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12268	NP_001247272.1	PLN02996	12..463	CDD:215538	167/461 (36%)
		FAR-N_SDR_e	22..347	CDD:187547	131/336 (39%)
		FAR_C	372..463	CDD:176924	28/90 (31%)
FAR2	XP_011519049.1	PLN02996	22..467	CDD:215538	167/462 (36%)
		FAR-N_SDR_e	31..335	CDD:187547	128/317 (40%)
		Sterile	377..467	CDD:281068	28/89 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750