DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12268 and CG14893

DIOPT Version :9

Sequence 1:	NP_001247272.1	Gene:	CG12268 / 42833	FlyBaseID:	FBgn0039131	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_650568.2	Gene:	CG14893 / 42023	FlyBaseID:	FBgn0038451	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	167/519 - (32%)
Similarity:	282/519 - (54%)	Gaps:	29/519 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ILRSDADCGESDIAKFYANKTILITGATGFMGKVLVEKLLRSCADLNVIYLLIRTKKGVDPSVRK 67
            :.|::.|.|   |..||.:|.:.:||||||:|||::|||||: .::..||.::|.|:|.|...|.
  Fly     7 VSRTEMDNG---IQGFYKDKVVFLTGATGFLGKVIIEKLLRT-TEVKRIYAMMRPKRGKDIQERL 67

  Fly    68 EQYFKCVIFGKLLEKNPGIVDKVRVVKGDLLEPDLGLSANDTNTLASNVEVVFHCAANVRFDQPL 132
            ..:.|..:|..||:..|..:.::.|:.||.|:||||::.:|...|.|.|.:|.|.||.|||::||
  Fly    68 AIWQKDPLFEVLLKAKPDALKRIFVIAGDCLDPDLGINRSDRKLLVSEVHIVIHGAATVRFNEPL 132

  Fly   133 RPMVMMNVVGTLKVLRLAEKMSQLQALVHVSTSYCQCNESVLEERAYP----APQNPFSIIEMVE 193
            ...:.:|..||..:|:||::|.||:|.:|:||::..|....:||:.||    ...|  |::.|.|
  Fly   133 HVALAINTRGTRLMLQLAKEMLQLEAYLHISTAFSNCVIFRIEEKFYPEHLTCDAN--SVLAMSE 195

  Fly   194 TMDDEALAEITPKLLNGLPNTYAYSKALSEDLICRYNNKLPIIITRPSIVTAAIHEPLPGWIEGV 258
            .:.::.:.::.|.|:...||||.|:|||:||::.|....||:.|.|||::.|...||:.|||:.:
  Fly   196 LLSEQMMDKLAPTLVGNFPNTYTYTKALAEDVVLREFGDLPLSIFRPSVIIATHEEPVSGWIDNL 260

  Fly   259 NGPTGLMIGAARGVIRSMHCNPDYASTVIPVDKAINGMILCGYQRGK-ASQEKGNKQTGVEFCNL 322
            .||...:.|.:.||:|....:.|..::::|||...|..:...:|..| .||.....|..:  ..|
  Fly   261 YGPIAHIYGVSHGVLRLTTYDKDGYASLVPVDYCANAALASIWQTSKDKSQRNAISQPAI--YTL 323

  Fly   323 CISSKALMSWGDSIETGRRFFYETPLSFALWYPGGSIKKNYYHHL-------FCVIFFHYLPAYF 380
            ..|.|.|:...|.|:.......:.||:..:|||       :.|::       ....|:|.||.||
  Fly   324 APSEKNLLLNTDFIKHSLIHRNDFPLTKMIWYP-------FVHNISNPRIFPLAAFFYHTLPGYF 381

  Fly   381 IDFWLLVFGQKPFLLNVQRKVSMGLKLLQYYTTKRWEFRNERFQEMSSQLSLLDQDLFDTSVGQV 445
            .|..|.:.|:||.|:.:.|.:...:.:|:::....|.|..:....:...:|..|:.|::..:..:
  Fly   382 YDLALRLSGRKPRLVKLYRSIHANIAVLEHFMNNSWHFETKSTDRLRVMMSPEDRRLYNFDMETL 446

  Fly   446 NWETYISNYIVGMRTYILGE--SEDTLPQARKVLRRLYILDWVSKVLFFSLSFWFLWTHLDGFV 507
            :|:.|....:.|||.|:..|  ::::|.|.|::..||.||.:....|...::.:.|||.:..|:
  Fly   447 DWKEYFRKALFGMRLYLTKEPPTQESLEQGRRLFYRLKILHYSFVTLLCVIAGFLLWTLVRLFI 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12268	NP_001247272.1	PLN02996	12..463	CDD:215538	151/462 (33%)
		FAR-N_SDR_e	22..347	CDD:187547	117/329 (36%)
		FAR_C	372..463	CDD:176924	25/90 (28%)
CG14893	NP_650568.2	PLN02996	19..452	CDD:215538	145/444 (33%)
		FAR-N_SDR_e	23..339	CDD:187547	117/320 (37%)
		Sterile	375..465	CDD:281068	24/89 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466768
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	10	9.900