DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12268 and CG5065

DIOPT Version :9

Sequence 1:	NP_001247272.1	Gene:	CG12268 / 42833	FlyBaseID:	FBgn0039131	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001163168.1	Gene:	CG5065 / 36860	FlyBaseID:	FBgn0034145	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	187/514 - (36%)
Similarity:	306/514 - (59%)	Gaps:	7/514 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RSDADCGESDIAKFYANKTILITGATGFMGKVLVEKLLRSCADLNVIYLLIRTKKGVDPSVRKEQ 69
            |:| |.....||:|||.:::.|||.||||||||||||||||.::..||||||.|:|.:.|.|..:
  Fly   110 RAD-DTSYVPIAQFYAGRSVFITGGTGFMGKVLVEKLLRSCPEIRNIYLLIRPKRGQEVSARLTE 173

  Fly    70 YFKCVIFGKLLEKNPGIVDKVRVVKGDLLEPDLGLSANDTNTLASNVEVVFHCAANVRFDQPLRP 134
            .....:|..|.::.|..:.||..:.||:...:||:|..|.|.|..||.||||.||.|:||:.|:.
  Fly   174 LLNAPLFESLRQEKPKELSKVIPISGDITSEELGISEKDQNLLCRNVSVVFHSAATVKFDEKLKL 238

  Fly   135 MVMMNVVGTLKVLRLAEKMSQLQALVHVSTSYCQCNESVLEERAYPAPQNPFSIIEMVETMDDEA 199
            .|.:|::||.:::.|..:|..|.||:||||:||.|:.:.:.|..|..|.||..||.::..:.::.
  Fly   239 SVTINMLGTKRLVELCHRMLSLDALIHVSTAYCNCDRTDVSEVIYAPPYNPDDIISLINWLPEDI 303

  Fly   200 LAEITPKLLNGLPNTYAYSKALSEDLICRYNNKLPIIITRPSIVTAAIHEPLPGWIEGVNGPTGL 264
            |.::||:|:...||||.::|||:|.::.:....||:.|.|||||||:::||..||::..||||||
  Fly   304 LDQLTPRLIGKRPNTYTFTKALAEHMLLKEAGNLPVAIVRPSIVTASLNEPFAGWVDNFNGPTGL 368

  Fly   265 MIGAARGVIRSMHCNPDYASTVIPVDKAINGMILCGYQRGKASQEKGNKQTGVEFCNLCISSKAL 329
            :...|:|:.|:|.|..:|.:.::|||..||.||...::...      .|...:...|.|...:..
  Fly   369 VSALAKGMFRTMMCEKNYVADMVPVDIVINLMIAAAWRTAT------RKSNNLLIYNCCTGQRNP 427

  Fly   330 MSWGDSIETGRRFFYETPLSFALWYPGGSIKKNYYHHLFCVIFFHYLPAYFIDFWLLVFGQKPFL 394
            :.|.:.::.......:.||...||||.|.::.|...:....|..|:||||.:|....:.|:|||:
  Fly   428 IIWSEFVKHAMTSVRKHPLEGCLWYPTGDLRMNRPMNTLNCIAKHFLPAYILDGVARIMGKKPFV 492

  Fly   395 LNVQRKVSMGLKLLQYYTTKRWEFRNERFQEMSSQLSLLDQDLFDTSVGQVNWETYISNYIVGMR 459
            :|||.|::..::.|:|:.|::|.|:::....:...||..|:::|...|..:||:.|:..|::|.|
  Fly   493 VNVQNKIAKAVECLEYFATRQWRFKDDNVHALLHTLSPKDREIFVFDVRHINWDKYVERYVLGFR 557

  Fly   460 TYILGESEDTLPQARKVLRRLYILDWVSKVLFFSLSFWFLWTHLDGFVERSDAFIRSSL 518
            .::..:..::||.:||.:.|||.|..::|::...|::.||.:......:...:|:.::|
  Fly   558 EFLFKQRPESLPASRKRMLRLYYLHQLTKLVAVLLTWRFLMSRSKRLNDLWSSFLENAL 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12268	NP_001247272.1	PLN02996	12..463	CDD:215538	170/450 (38%)
		FAR-N_SDR_e	22..347	CDD:187547	126/324 (39%)
		FAR_C	372..463	CDD:176924	30/90 (33%)
CG5065	NP_001163168.1	FAR-N_SDR_e	126..445	CDD:187547	126/324 (39%)
CG5065	NP_001163168.1	Sterile	472..562	CDD:281068	30/89 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466822
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	1	0.950	-	0.712175	Normalized mean entropy	S3219
OMA	1	1.010	-	-		QHG28069
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	12	11.860