DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12268 and CG1441

DIOPT Version :9

Sequence 1:	NP_001247272.1	Gene:	CG12268 / 42833	FlyBaseID:	FBgn0039131	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_610535.1	Gene:	CG1441 / 36029	FlyBaseID:	FBgn0033464	Length:	517	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	190/512 - (37%)
Similarity:	290/512 - (56%)	Gaps:	35/512 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DADCGESD-IAKFYANKTILITGATGFMGKVLVEKLLRSCADLNVIYLLIRTKKGVDPSVRKEQY 70
            :.|..|.| ||:.:..:::.|||.|||:||||||||||||..|..||||||.|||.||..|.:..
  Fly    19 EIDDNEVDRIAECFKGRSLFITGGTGFLGKVLVEKLLRSCGGLKRIYLLIRPKKGKDPQERIKDI 83

  Fly    71 FKCVIFG--KLLEKNPGIVDKVRVVKGDLLEPDLGLSANDTNTLASNVEVVFHCAANVRFDQPLR 133
            |:.|:|.  |.:.....|:.:|..:.||:|.|.||:|..|..||...|.:|:||||.||||:|||
  Fly    84 FQNVLFDQVKQMRGEEHILQQVVAIAGDVLSPGLGISEKDLETLRQEVSIVYHCAATVRFDEPLR 148

  Fly   134 PMVMMNVVGTLKVLRLAEKMSQLQALVHVSTSYCQCNESVLEERAYPAPQNPFSIIEMVETMDDE 198
            ..|.||..||..:|.||..:..|....:.||:||..:...|.|:.|..|.:|..:::..|.:.|:
  Fly   149 NAVFMNTRGTKYMLELALTLKHLDFFAYCSTAYCHLHVKTLYEKPYDPPADPHKVMQACEWLTDD 213

  Fly   199 ALAEITPKLLNGLPNTYAYSKALSEDLICRYNNKLPIIITRPSIVTAAIHEPLPGWIEGVNGPTG 263
            .:|.|..|:|..:||||||:|:|:|.|:.....:||.:|.|||||.....||:|||.:.:|||||
  Fly   214 EVATIERKVLGAIPNTYAYTKSLAEALVVEKFEELPAVILRPSIVIPIWKEPIPGWTDNINGPTG 278

  Fly   264 LMIGAARGVIRSMHCNPDYASTVIPVDKAINGMILCGYQRGKASQEKGNKQTGVEFCNLCISSKA 328
            |:|||.:||||:|:||.......:|||.|:||:::..::...|..:|.|:     ..::..|:..
  Fly   279 LLIGAGKGVIRTMYCNSSGYGDFLPVDVAVNGILVASWRNITAGTDKTNR-----VAHMTSSNDI 338

  Fly   329 LMSWGDSIETGRRFF-YETPLSFALWYPGGSIKKNYYHHLFCVIFFHYLPAYFIDFWLLVFGQKP 392
            .:||.:.||.||... .:.||:...||||||:|.||:.|..|::.|.::||.|:|..|.:....|
  Fly   339 KVSWAEIIELGRWVIENKVPLNGVAWYPGGSMKSNYWVHFICMVLFQWMPALFVDALLWILRYPP 403

  Fly   393 FLLNVQRKVSMGLKLLQYYTTKRWEFRNERFQEMSSQLS----------LLDQDLFDTSVGQVNW 447
            .|..||.::..|.::.:||....|.|.|....::...::          .::.||.|
  Fly   404 VLCRVQNRIYKGFEVFEYYANNVWNFDNSEAVKLRKLMNNKERRTYVIEKIELDLID-------- 460

  Fly   448 ETYISNYIVGMRTYILGESEDTLPQARKVLRRLYILD------WVSKVLFFSLSFWF 498
              |.:|.::..|..||.||::::|.||:.::.::::|      |:..:|:.....:|
  Fly   461 --YFTNCVLCARRLILKESDESIPAARRHMKVMWVVDKVYKGIWIFGILYMLYRCFF 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12268	NP_001247272.1	PLN02996	12..463	CDD:215538	178/464 (38%)
		FAR-N_SDR_e	22..347	CDD:187547	139/327 (43%)
		FAR_C	372..463	CDD:176924	22/100 (22%)
CG1441	NP_610535.1	PLN02996	24..464	CDD:215538	176/454 (39%)
		FAR-N_SDR_e	35..348	CDD:187547	136/317 (43%)
		Sterile	385..475	CDD:281068	22/99 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466734
Domainoid	1	1.000	159	1.000	Domainoid score	I1277
eggNOG	1	0.900	-	-		E1_COG3320
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I1437
Isobase	1	0.950	-	0.712175	Normalized mean entropy	S3219
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	1	1.000	-	-		mtm964
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
	11	10.850