DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12268 and Far2

DIOPT Version :9

Sequence 1:	NP_001247272.1	Gene:	CG12268 / 42833	FlyBaseID:	FBgn0039131	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001334445.1	Gene:	Far2 / 330450	MGIID:	2687035	Length:	515	Species:	Mus musculus

Alignment Length:	525	Identity:	188/525 - (35%)
Similarity:	289/525 - (55%)	Gaps:	29/525 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SDIAKFYANKTILITGATGFMGKVLVEKLLRSCADLNVIYLLIRTKKGVDPSVRKEQYFKCVIFG 77
            |.||.||:||:|||||||||:||||:|||.|:...|.|||:|:|.|.|.....|..|.....:|.
Mouse     2 SMIAAFYSNKSILITGATGFLGKVLMEKLFRTSPHLKVIYILVRPKSGQTLQERVFQILNSKLFE 66

  Fly    78 KLLEKNPGIVDKVRVVKGDLLEPDLGLSANDTNTLASNVEVVFHCAANVRFDQPLRPMVMMNVVG 142
            |:.|..|.:.:|:|.:..||.:.|..:|..|...|.|...::|||||.||||..||..|.:||..
Mouse    67 KVKEVCPNVHEKIRPISADLNQRDFAISKEDVQELLSCTNIIFHCAATVRFDAHLREAVQLNVTA 131

  Fly   143 TLKVLRLAEKMSQLQALVHVSTSYCQCNESVLEERAYPAPQNPFSIIEMVETMDDEALAEITPKL 207
            |.::|.:|.:|.:|:|.:|:||::..||.|.::|..||.|..|..||:.:|.:||..:.||||||
Mouse   132 TQQLLLMASQMPKLEAFIHISTAFSNCNLSHIDEVIYPCPVEPRKIIDSMEWLDDSIIEEITPKL 196

  Fly   208 LNGLPNTYAYSKALSEDLICRYNNKLPIIITRPSIVTAAIHEPLPGWIEGVNGPTGLMIGAARGV 272
            :...||||.|:|||.|.::.:.:..|.:.|.|||||.|...||.|||::.:|||:||:|...:|.
Mouse   197 IGDRPNTYTYTKALGEIVVQQESGNLNVAIVRPSIVGATWQEPFPGWVDNLNGPSGLIIATGKGF 261

  Fly   273 IRSMHCNPDYASTVIPVDKAINGMILCGY----QRGKASQEKGNKQTGVEFCNLCISSKALMSWG 333
            :||:...|...:.|||||..:|..|..|:    .|.|::....:....:..||.......:::
Mouse   262 LRSIKATPMAVADVIPVDTVVNLTIAVGWYTAVHRPKSTLIYHSTSGNLNPCNWYKMGLQVLA-- 324

  Fly   334 DSIETGRRFFYETPLSFALWYPGGSI-KKNYYHHLFCVIFFHYLPAYFIDFWLLVFGQKPFLLNV 397
             :||       :.|...|...|.... ..|:..|.:..: .|.:||...||:|.:.|:||.:|.:
Mouse   325 -TIE-------KIPFESAFRRPNADFTTSNFTTHYWNTV-SHRVPAIIYDFYLRLTGRKPRMLKL 380

  Fly   398 QRKVSMGLKLLQYYTTKRWEFRNERFQEMSSQLSLLDQDLFDTSVGQVNWETYISNYIVGMRTYI 462
            ..::...:.:|:|:....||:.....:.:.|:||..||.:|:..|.|:||..||.||::|::.|:
Mouse   381 MNRLLKTISMLEYFINHSWEWSTNNTEMLLSELSPEDQRVFNFDVRQLNWLEYIENYVLGVKKYL 445

  Fly   463 LGESEDTLPQARKVLRRLYILDWVSKVLFFSLSFWFL-----------WTHLDGFVERSDAFIRS 516
            |.|....:|:|::.||||..:.::.....| |..|.|           |..:..|..:..::.|:
Mouse   446 LKEDLAGIPKAKQHLRRLRNIHYLFNTALF-LIIWRLLIARSQMARNVWFFIVSFCYKFISYFRA 509

  Fly   517 SLSTI 521
            | ||:
Mouse   510 S-STL 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12268	NP_001247272.1	PLN02996	12..463	CDD:215538	170/454 (37%)
		FAR-N_SDR_e	22..347	CDD:187547	129/328 (39%)
		FAR_C	372..463	CDD:176924	30/90 (33%)
Far2	NP_001334445.1	FAR-N_SDR_e	11..315	CDD:187547	126/303 (42%)
Far2	NP_001334445.1	Sterile	357..447	CDD:397244	30/89 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847929
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750