DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12268 and Far1

DIOPT Version :9

Sequence 1:	NP_001247272.1	Gene:	CG12268 / 42833	FlyBaseID:	FBgn0039131	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001011933.1	Gene:	Far1 / 293173	RGDID:	1306647	Length:	515	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	181/537 - (33%)
Similarity:	284/537 - (52%)	Gaps:	54/537 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 IAKFYANKTILITGATGFMGKVLVEKLLRSCADLNVIYLLIRTKKGVDPSVRKEQYFKCVIFGKL 79
            |.::|..|.||:||||||:||||:|||||||..:|.:|:|:|.|.|..|..|.|:.....:|.:|
  Rat     4 IPEYYEGKNILLTGATGFLGKVLLEKLLRSCPKVNSVYVLVRQKAGQTPQERVEEILSGKLFDRL 68

  Fly    80 LEKNPGIVDKVRVVKGDLLEPDLGLSANDTNTLASNVEVVFHCAANVRFDQPLRPMVMMNVVGTL 144
            .::||....|:..:..:|.:|.|.||..|...:..:..|:|||||.|||::.||..|.:||:.|.
  Rat    69 RDENPDFRQKIIAINSELTQPKLALSEEDKEIIIDSTNVIFHCAATVRFNENLRDAVQLNVIATR 133

  Fly   145 KVLRLAEKMSQLQALVHVSTSYCQCNESVLEERAYPAPQNPFSIIEMVETMDDEALAEITPKLLN 209
            :::.||::|..|:..:||||:|..||...::|..||.|.:|..:|:.:|.|||..:.:|||||:.
  Rat   134 QLILLAQQMKNLEVFMHVSTAYAYCNRKHIDEVVYPPPVDPKKLIDSLEWMDDGLVNDITPKLIG 198

  Fly   210 GLPNTYAYSKALSEDLICRYNNKLPIIITRPSIVTAAIHEPLPGWIEGVNGPTGLMIGAARGVIR 274
            ..||||.|:|||:|.::.:...||.:.|.|||||.|:..||.||||:..|||:||.|.|.:|::|
  Rat   199 DRPNTYIYTKALAEYVVQQEGAKLNVAIVRPSIVGASWKEPFPGWIDNFNGPSGLFIAAGKGILR 263

  Fly   275 SMHCNPDYASTVIPVDKAINGMILCGYQRGKASQEKGNKQTGVEFCNLCISSKALMSWGDSIETG 339
            :|..:.:..:.::|||..:|..:...:..|.      |:...:...|....|.....||:..:..
  Rat   264 TMRASNNALADLVPVDVVVNTSLAAAWYSGV------NRPRNIMVYNCTTGSTNPFHWGEVGDYL 322

  Fly   340 RRFFYETPLSFALWYPGGSIKKNYYHHLFCVIFFHY-------LPAYFIDFWLLVFGQKPFLLNV 397
            ...|...||:....:|   ..|.|.::|    ..||       :||..:|..|.:.||||:::..
  Rat   323 NHSFKTNPLNQVFRHP---YVKFYSNNL----MLHYWKGVKHTVPALLLDLALRLTGQKPWMMKT 380

  Fly   398 QRKVSMGLKLLQYYTTKRWEFRNERFQEMSSQLSLLDQDLFDTSVGQVNWETYISNYIVGMRTYI 462
            ..::...:..|:|:|:..|.:..:....:.:||:..|:..|:..|.|::|..||.||.:|.:.|:
  Rat   381 ITRLHKAMVFLEYFTSNSWVWNTDNVNMLMNQLNPEDKKTFNIDVRQLHWAEYIENYCMGTKKYV 445

  Fly   463 LGESEDTLPQARKVLRR-----------LYILDW---------VSKVLFF--SLSFWFLWTHLDG 505
            |.|....||.|||.|.:           |.||.|         ...:.:|  ||.:.||
  Rat   446 LNEEMSGLPAARKHLNKLRNIRYGFNTILVILIWRIFIARSQMARNIWYFVVSLCYKFL------ 504

  Fly   506 FVERSDAFIRSSLSTIY 522
                  ::.|:|.:..|
  Rat   505 ------SYFRASSTMRY 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12268	NP_001247272.1	PLN02996	12..463	CDD:215538	161/454 (35%)
		FAR-N_SDR_e	22..347	CDD:187547	126/324 (39%)
		FAR_C	372..463	CDD:176924	27/97 (28%)
Far1	NP_001011933.1	PLN02996	2..446	CDD:215538	161/454 (35%)
		FAR-N_SDR_e	11..330	CDD:187547	126/324 (39%)
		Sterile	371..447	CDD:281068	21/75 (28%)
		Necessary and sufficient for PEX19-mediated localization into peroxisome membrane. /evidence=ECO:0000250\|UniProtKB:Q8WVX9	451..507		15/67 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351489
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11011
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.850