DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12268 and fard-1

DIOPT Version :9

Sequence 1:	NP_001247272.1	Gene:	CG12268 / 42833	FlyBaseID:	FBgn0039131	Length:	531	Species:	Drosophila melanogaster
Sequence 2:	NP_001370741.1	Gene:	fard-1 / 180582	WormBaseID:	WBGene00022200	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	471	Identity:	157/471 - (33%)
Similarity:	259/471 - (54%)	Gaps:	20/471 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 YANKTILITGATGFMGKVLVEKLLRSCADLNVIYLLIRTKKGVDPSVRKEQYFKCVIFGKLLEKN 83
            ||..::|:||.|||:|||:|||||.:..|:..|||:|||:||.:|..|........:|.::.::.
Worm     9 YAGSSVLLTGGTGFLGKVIVEKLLWTIDDIQNIYLMIRTRKGKNPQERLSGLLHDPLFNRIRQEK 73

  Fly    84 PGIVDKVRVVKGDLLEPDLGLSANDTNTLASNVEVVFHCAANVRFDQPLRPMVMMNVVGTLKVLR 148
            |...||::.:.||::..:||:...|...:..||.||.|.||.|:||:.||..|.|||:||.:::.
Worm    74 PEAFDKLKAIGGDMMVENLGMDPEDVMLIRDNVNVVIHSAATVKFDEHLRAAVTMNVIGTKRIID 138

  Fly   149 LAEKMSQLQALVHVSTSYCQCNESVLEERAYPAPQNPFSIIEMVETMDDEALAEITPKLLNGLPN 213
            |..::..|:.||||||:|..|:.....|:.|.:|..|..:::.:..||||.|.:||||:|...||
Worm   139 LCHQIKDLKVLVHVSTAYANCDRFETTEKIYKSPMAPQKLVDALSWMDDETLTKITPKILGLRPN 203

  Fly   214 TYAYSKALSEDLICRYNNKLPIIITRPSIVTAAIHEPLPGWIEGVNGPTGLMIGAARGVIRSMHC 278
            ||..:|||:|..|......:|:||.|||||.|....|||||.:.:|||||:.....|||:.:|..
Worm   204 TYTLTKALAESTIETEAKDIPVIIIRPSIVGAMWQGPLPGWTDNINGPTGIFAAVGRGVLTNMCG 268

  Fly   279 NPDYASTVIPVDKAINGMILCGYQRGKASQEKGNKQTGVEFCNLCISSKALMSWGDSIETGRRFF 343
            :.:..:.:||||...|.:|      ..||.......|.:...:........:.||..:....:|:
Worm   269 SSESKADIIPVDIVANMII------ASASYRTSINTTEIPVIHCSSGELNPLYWGHIVLFLEQFY 327

  Fly   344 YETPLS--FALWYPGGSIKKNYYH---HLFCVIFF--HYLPAYFIDFWLLVFGQKPFLLNVQRKV 401
            .:.|:.  ||       :...|:|   .||.:.::  |::||...|....:.|::...:.:..||
Worm   328 KKYPMEQCFA-------VPSTYFHKSRSLFLINYYIKHHIPAAISDISARLIGKRKNNVKLYSKV 385

  Fly   402 SMGLKLLQYYTTKRWEFRNERFQEMSSQLSLLDQDLFDTSVGQVNWETYISNYIVGMRTYILGES 466
            ...::.|.::||:.|.|......|...:::..||..::..|.||:|.:|:.:|::|::.::|.|:
Worm   386 WKMIETLHFFTTRGWSFNARGLPEFFEKMTPADQKEYNFDVRQVDWNSYLFDYVMGIKKFLLKEN 450

  Fly   467 EDTLPQARKVLRRLYI 482
            .:.|.::|..|.::.|
Worm   451 LENLNRSRAHLLKMRI 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12268	NP_001247272.1	PLN02996	12..463	CDD:215538	151/450 (34%)
		FAR-N_SDR_e	22..347	CDD:187547	120/324 (37%)
		FAR_C	372..463	CDD:176924	22/92 (24%)
fard-1	NP_001370741.1	FAR-N_SDR_e	13..331	CDD:187547	120/323 (37%)
fard-1	NP_001370741.1	Sterile	358..448	CDD:397244	22/89 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165456
Domainoid	1	1.000	74	1.000	Domainoid score	I5949
eggNOG	1	0.900	-	-		E1_COG3320
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.712175	Normalized mean entropy	S3219
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D221518at33208
OrthoFinder	1	1.000	-	-		FOG0000172
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11011
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X145
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.800