DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gdh and GDH3

DIOPT Version :9

Sequence 1:	NP_524470.4	Gene:	Gdh / 42832	FlyBaseID:	FBgn0001098	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_009339.1	Gene:	GDH3 / 851237	SGDID:	S000000058	Length:	457	Species:	Saccharomyces cerevisiae

Alignment Length:	442	Identity:	118/442 - (26%)
Similarity:	187/442 - (42%)	Gaps:	75/442 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 SLVDDMKGKLTRDEKKQKVKGILMLMQPCDHIIEIAFPLRRDAGNYEMITGYRAQHSTHKTPTKG 139
            |.|:|.|    ..||..:.|.:|.::...:.||:.......|.|..|:..|||.|.::.|.|.||
Yeast    16 SSVEDSK----IFEKFPQYKKVLPIVSVPERIIQFRVTWENDNGEQEVAQGYRVQFNSAKGPYKG 76

  Fly   140 GIRFSLDVSRDEVKALSALMTFKCACVDVPFGGAKAGLKINPKEYSEHELEKITRRFTLELAKKG 204
            |:||...|:...:|.|.....||.|...:..||.|.||.::.|..|::|:.:|...|..||::
Yeast    77 GLRFHPSVNLSILKFLGFEQIFKNALTGLDMGGGKGGLCVDLKGKSDNEIRRICYAFMRELSR-- 139

  Fly   205 FIGPGVDVPAPDMGTGEREMSWIADTYAKTIGHLDINAHACVTGKPINQGGIHGRVSATGRGVFH 269
            .||...||||.|:|.|.||:.::...|.......:    ..:|||.:|.||...|..|||.|:.:
Yeast   140 HIGKDTDVPAGDIGVGGREIGYLFGAYRSYKNSWE----GVLTGKGLNWGGSLIRPEATGFGLVY 200

  Fly   270 GLENFINEANYMSQIGTTPGWGGKTFIVQGFGNVGLHTTRYLTRAGATCIGVIEHDGTLYNPEGI 334
            ..:..|:.|....:     .:.||...:.|.|||..:....:...|...:.:.:..|.:.:..||
Yeast   201 YTQAMIDYATNGKE-----SFEGKRVTISGSGNVAQYAALKVIELGGIVVSLSDSKGCIISETGI 260

  Fly   335 DP-------------KLLEDYKNEHGT--------IVGYQNAKPYEGENLMFEKCDIFIPAAVEK 378
            ..             |.||:..:|:.|        :.|   |:|:    ......||.:|.|.:.
Yeast   261 TSEQIHDIASAKIRFKSLEEIVDEYSTFSESKMKYVAG---ARPW----THVSNVDIALPCATQN 318

  Fly   379 VITSENANRIQA---KIIAEAANGPTTPAADKILIDRN---------ILVIPDLYINAGGVTVSF 431
            .::.:.|..:.|   |.:||.||..:||.|..:.....         :...|....|.|||.||.
Yeast   319 EVSGDEAKALVASGVKFVAEGANMGSTPEAISVFETARSTATNAKDAVWFGPPKAANLGGVAVSG 383

  Fly   432 FEWLKNLNHVSYGRLTFKYERESNYHLLASVQQSIERII----ND--ESVQE 477
            .|..:|..     ::|:..||         |.|.:::|:    ||  ::.||
Yeast   384 LEMAQNSQ-----KVTWTAER---------VDQELKKIMINCFNDCIQAAQE 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdh	NP_524470.4	GdhA	98..560	CDD:223411	110/419 (26%)
		ELFV_dehydrog_N	104..233	CDD:280903	46/128 (36%)
		NAD_bind_1_Glu_DH	254..552	CDD:133445	60/263 (23%)
GDH3	NP_009339.1	PRK09414	4..454	CDD:181834	118/442 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I2038
eggNOG	1	0.900	-	-		E1_COG0334
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1193
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S1271
OMA	1	1.010	-	-		QHG54967
OrthoFinder	1	1.000	-	-		FOG0001473
OrthoInspector	1	1.000	-	-		mtm9211
orthoMCL	1	0.900	-	-		OOG6_100455
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R306
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.710