DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gdh and GDH1

DIOPT Version :9

Sequence 1:	NP_524470.4	Gene:	Gdh / 42832	FlyBaseID:	FBgn0001098	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_197318.1	Gene:	GDH1 / 831935	AraportID:	AT5G18170	Length:	411	Species:	Arabidopsis thaliana

Alignment Length:	389	Identity:	161/389 - (41%)
Similarity:	222/389 - (57%)	Gaps:	46/389 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 DEKKQKVKGILMLMQPCDHI-IEIAFPLRRDAGNYEMITGYRAQHSTHKTPTKGGIRFSLDVSRD 150
            |.|.:|     .|:.|...| :|...|  :|.|......|:|.||...:.|.|||||:..:|..|
plant    21 DSKLEK-----SLLIPFREIKVECTIP--KDDGTLASFVGFRVQHDNARGPMKGGIRYHPEVDPD 78

  Fly   151 EVKALSALMTFKCACVDVPFGGAKAGLKINPKEYSEHELEKITRRFTLELAKKGFIGPGVDVPAP 215
            ||.||:.|||:|.|...:|:||||.|:..:|.:.|..|||::||.||.::  ...||...|||||
plant    79 EVNALAQLMTWKTAVAKIPYGGAKGGIGCDPSKLSISELERLTRVFTQKI--HDLIGIHTDVPAP 141

  Fly   216 DMGTGEREMSWIADTYAKTIGHLDINAHACVTGKPINQGGIHGRVSATGRGVFHGLENFINEANY 280
            |||||.:.|:||.|.|:|..|:    :.|.||||||:.||..||.:||||||..|.|..:||.
plant   142 DMGTGPQTMAWILDEYSKFHGY----SPAVVTGKPIDLGGSLGRDAATGRGVMFGTEALLNEH-- 200

  Fly   281 MSQIGTTPGWGGKTFIVQGFGNVGLHTTRYLTRAGATCIGVIEHDGTLYNPEGID-PKLLEDYKN 344
                |.|  ..|:.|::|||||||....:.::..|...:.|.:..|.:.|.:||| |.||:..|
plant   201 ----GKT--ISGQRFVIQGFGNVGSWAAKLISEKGGKIVAVSDITGAIKNKDGIDIPALLKHTK- 258

  Fly   345 EHGTIVGYQNAKPYEGENLMFEKCDIFIPAAVEKVITSENANRIQAKIIAEAANGPTTPAADKIL 409
            ||..:.|:..|.|.:..:::.|.|||.:|||:..||..||||.|:||.|.||||.||.|.||:||
plant   259 EHRGVKGFDGADPIDPNSILVEDCDILVPAALGGVINRENANEIKAKFIIEAANHPTDPDADEIL 323

  Fly   410 IDRNILVIPDLYINAGGVTVSFFEWLKNLNHVSYGRLTFKYERESNYHLLASVQQSIERIINDE 473
            ..:.::::||:|.|:||||||:|||::|:.       .|.:|.|.               :|||
plant   324 SKKGVVILPDIYANSGGVTVSYFEWVQNIQ-------GFMWEEEK---------------VNDE 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdh	NP_524470.4	GdhA	98..560	CDD:223411	158/378 (42%)
		ELFV_dehydrog_N	104..233	CDD:280903	58/129 (45%)
		NAD_bind_1_Glu_DH	254..552	CDD:133445	89/221 (40%)
GDH1	NP_197318.1	PLN02477	1..410	CDD:178095	161/389 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	157	1.000	Domainoid score	I1308
eggNOG	1	0.900	-	-		E1_COG0334
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	281	1.000	Inparanoid score	I872
OMA	1	1.010	-	-		QHG54967
OrthoDB	1	1.010	-	-		D692851at2759
OrthoFinder	1	1.000	-	-		FOG0001473
OrthoInspector	1	1.000	-	-		mtm1157
orthoMCL	1	0.900	-	-		OOG6_100455
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1737
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.740