DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gdh and bb8

DIOPT Version :9

Sequence 1:	NP_524470.4	Gene:	Gdh / 42832	FlyBaseID:	FBgn0001098	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_651140.1	Gene:	bb8 / 42756	FlyBaseID:	FBgn0039071	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	248/540 - (45%)
Similarity:	352/540 - (65%)	Gaps:	25/540 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LPTAVMQSSRGYATEHQIPDRLKDVPTAKDPRFFDMVEYFFHRGCQIAEESLVDDMK--GKLTRD 87
            :|..|::.|     .||:|::||.|.|.|||.|.:||.|::|:..|..|.:|:.:|:  ..:..:
  Fly    16 MPRQVLKRS-----AHQVPEKLKKVETDKDPEFSEMVLYYYHKAAQTMEPALLKEMEKYPHMKPE 75

  Fly    88 EKKQKVKGILMLMQPCDHIIEIAFPLRRDAGNYEMITGYRAQHSTHKTPTKGGIRFSLDVSRDEV 152
            |::.:|..||.|:......:|:.||:.|..|.||:|:|||:.|..|:.|.|||||::|||:..||
  Fly    76 ERQARVTAILNLLGSVSTSVEVNFPIVRKNGTYEIISGYRSHHVRHRLPLKGGIRYALDVNESEV 140

  Fly   153 KALSALMTFKCACVDVPFGGAKAGLKINPKEYSEHELEKITRRFTLELAKKGFIGPGVDVPAPDM 217
            |||:|:||||||||:||:||:|.|:.|:||:|:..||:.||||:|:||.|:..||||:||||||:
  Fly   141 KALAAIMTFKCACVNVPYGGSKGGICIDPKKYTVDELQTITRRYTMELLKRNMIGPGIDVPAPDV 205

  Fly   218 GTGEREMSWIADTYAKTIGHLDINAHACVTGKPINQGGIHGRVSATGRGVFHGLENFINEANYMS 282
            .||.||||||.|.|.||.|:.|||:.|.|||||::.|||:||.|||||||:...:.|:.:..:|.
  Fly   206 NTGPREMSWIVDQYQKTFGYKDINSSAIVTGKPVHNGGINGRHSATGRGVWKAGDLFLKDKEWMD 270

  Fly   283 QIGTTPGWGGKTFIVQGFGNVGLHTTRYLTRAGATCIGVIEHDGTLYNPEGIDPKLLEDYKNEHG 347
            .:....||..||.|||||||||....:|:..|||..||:.|.|.:|.|.:|||...|.:|..|..
  Fly   271 LLKWKTGWKDKTVIVQGFGNVGSFAAKYVHEAGAKVIGIKEFDVSLVNKDGIDINDLFEYTEEKK 335

  Fly   348 TIVGYQNAKPYEGENLMFEKCDIFIPAAVEKVITSENANRIQAKIIAEAANGPTTPAADKILIDR 412
            ||.||..|:..: |:|:..:.||.:|.|.:||||::||..|:||:|.|.|||||||:.:|||:|:
  Fly   336 TIKGYPKAQESK-EDLLVAETDILMPCATQKVITTDNAKDIKAKLILEGANGPTTPSGEKILLDK 399

  Fly   413 NILVIPDLYINAGGVTVSFFEWLKNLNHVSYGRLTFKYERESNYHLLASVQQSIERIINDESVQE 477
            .:|::||||.||||||||:||:|||:||||||::..|...|....|:.|:.:|:....:.:
  Fly   400 GVLLVPDLYCNAGGVTVSYFEYLKNINHVSYGKMNSKSTSELIIELMNSINESLHECPDSQ---- 460

  Fly   478 SLERRFGRVGGRIP-VTPSESFQKRISGASEKDIVHSGLDYTMERSARAIMKTAMKYNLGLDLRT 541
                        :| :.|::..::.....:|.|||.|.|...||.:||.|.:.|.|:.|..|||.
  Fly   461 ------------LPNICPNKKLKRIQQCTTEADIVDSALQTVMESAARGIKEMAHKFELCNDLRR 513

  Fly   542 AAYVNSIEKIFTTYRDAGLA 561
            ||||.|..|||.....:|::
  Fly   514 AAYVWSSFKIFQAMESSGIS 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdh	NP_524470.4	GdhA	98..560	CDD:223411	221/462 (48%)
		ELFV_dehydrog_N	104..233	CDD:280903	76/128 (59%)
		NAD_bind_1_Glu_DH	254..552	CDD:133445	130/298 (44%)
bb8	NP_651140.1	GdhA	72..532	CDD:223411	225/476 (47%)
		ELFV_dehydrog_N	95..221	CDD:280903	76/125 (61%)
		NAD_bind_1_Glu_DH	242..517	CDD:133445	126/291 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458022
Domainoid	1	1.000	157	1.000	Domainoid score	I1308
eggNOG	1	0.900	-	-		E1_COG0334
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	281	1.000	Inparanoid score	I872
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S1271
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D18899at7147
OrthoFinder	1	1.000	-	-		FOG0001473
OrthoInspector	1	1.000	-	-		otm51385
orthoMCL	1	0.900	-	-		OOG6_100455
Panther	1	1.100	-	-	P	PTHR11606
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R306
SonicParanoid	1	1.000	-	-		X1737
	13	12.780