DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gdh and glud1b

DIOPT Version :9

Sequence 1:	NP_524470.4	Gene:	Gdh / 42832	FlyBaseID:	FBgn0001098	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_955839.2	Gene:	glud1b / 373092	ZFINID:	ZDB-GENE-030828-1	Length:	542	Species:	Danio rerio

Alignment Length:	564	Identity:	367/564 - (65%)
Similarity:	449/564 - (79%)	Gaps:	25/564 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MY-HLKSLARQGARRQQELATLAKALP-TAVMQSSRGYATEHQIPDRLKDVPTAKDPRFFDMVEY 63
            || :...|..:||........:..||| ::.:...|.|:......|         ||.||.|||.
Zfish     1 MYRYFGELLTRGAGSALASGCVESALPASSSLLRVRHYSDAADKED---------DPNFFRMVEG 56

  Fly    64 FFHRGCQIAEESLVDDMKGKLTRDEKKQKVKGILMLMQPCDHIIEIAFPLRRDAGNYEMITGYRA 128
            ||.||..|.|..||:|:|.:.|.::|:.:|:|||.:::||:|::.::||::||.|.:|:|.||||
Zfish    57 FFDRGATIVENKLVEDLKTRETPEQKRSRVRGILKIIKPCNHVLSVSFPIKRDNGEWEVIEGYRA 121

  Fly   129 QHSTHKTPTKGGIRFSLDVSRDEVKALSALMTFKCACVDVPFGGAKAGLKINPKEYSEHELEKIT 193
            |||.|:||.|||||:|:|||.||||||::|||:|||.|||||||||||:||||:.||::||||||
Zfish   122 QHSQHRTPCKGGIRYSMDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPRNYSDNELEKIT 186

  Fly   194 RRFTLELAKKGFIGPGVDVPAPDMGTGEREMSWIADTYAKTIGHLDINAHACVTGKPINQGGIHG 258
            ||||:|||||||||||:|||||||.||||||||||||||.||.|.|||||||||||||:||||||
Zfish   187 RRFTIELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYANTIAHTDINAHACVTGKPISQGGIHG 251

  Fly   259 RVSATGRGVFHGLENFINEANYMSQIGTTPGWGGKTFIVQGFGNVGLHTTRYLTRAGATCIGVIE 323
            |:||||||||||:|||||||:|||::|.|||:..||||:|||||||||:.|||.|.||.|:|:.|
Zfish   252 RISATGRGVFHGIENFINEASYMSKLGLTPGFADKTFIIQGFGNVGLHSMRYLHRYGAKCVGIAE 316

  Fly   324 HDGTLYNPEGIDPKLLEDYKNEHGTIVGYQNAKPYEGENLMFEKCDIFIPAAVEKVITSENANRI 388
            .||:::||.|:|||.|||||.:||||||:.|::|||| |::..:|||.||||.||.:|.:||:.|
Zfish   317 IDGSIWNPNGMDPKELEDYKLQHGTIVGFPNSQPYEG-NILEAQCDILIPAAGEKQLTRKNAHNI 380

  Fly   389 QAKIIAEAANGPTTPAADKILIDRNILVIPDLYINAGGVTVSFFEWLKNLNHVSYGRLTFKYERE 453
            :||||||.|||||||.||||.|:||::||||:|:||||||||:|||||||||||||||||||||:
Zfish   381 KAKIIAEGANGPTTPDADKIFIERNVMVIPDMYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERD 445

  Fly   454 SNYHLLASVQQSIERIINDESVQESLERRFGRVGGRIPVTPSESFQKRISGASEKDIVHSGLDYT 518
            ||||||.             ||||||||:||:.||.||:.|:..||.|::||||||||||||.||
Zfish   446 SNYHLLM-------------SVQESLERKFGKQGGPIPIVPTADFQARVAGASEKDIVHSGLAYT 497

  Fly   519 MERSARAIMKTAMKYNLGLDLRTAAYVNSIEKIFTTYRDAGLAF 562
            ||||||.||:||.|||||||||||||||:|||:|..|.:|||.|
Zfish   498 MERSARQIMRTANKYNLGLDLRTAAYVNAIEKVFKVYNEAGLTF 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdh	NP_524470.4	GdhA	98..560	CDD:223411	330/461 (72%)
		ELFV_dehydrog_N	104..233	CDD:280903	97/128 (76%)
		NAD_bind_1_Glu_DH	254..552	CDD:133445	210/297 (71%)
glud1b	NP_955839.2	ELFV_dehydrog_N	97..224	CDD:280903	95/126 (75%)
		NAD_bind_1_Glu_DH	247..532	CDD:133445	210/298 (70%)
		ELFV_dehydrog	247..530	CDD:278631	209/296 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588141
Domainoid	1	1.000	296	1.000	Domainoid score	I1450
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55885
Inparanoid	1	1.050	752	1.000	Inparanoid score	I545
OMA	1	1.010	-	-		QHG54967
OrthoDB	1	1.010	-	-		D217293at33208
OrthoFinder	1	1.000	-	-		FOG0001473
OrthoInspector	1	1.000	-	-		otm25878
orthoMCL	1	0.900	-	-		OOG6_100455
Panther	1	1.100	-	-	LDO	PTHR11606
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R306
SonicParanoid	1	1.000	-	-		X1737
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940