DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gdh and glud1a

DIOPT Version :9

Sequence 1:	NP_524470.4	Gene:	Gdh / 42832	FlyBaseID:	FBgn0001098	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_997741.1	Gene:	glud1a / 317737	ZFINID:	ZDB-GENE-030114-2	Length:	544	Species:	Danio rerio

Alignment Length:	509	Identity:	359/509 - (70%)
Similarity:	427/509 - (83%)	Gaps:	14/509 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 DPRFFDMVEYFFHRGCQIAEESLVDDMKGKLTRDEKKQKVKGILMLMQPCDHIIEIAFPLRRDAG 118
            ||.||.|||.||.||..|.|:.||.|:|.:.|.::|:.:|:|||.:::||:|::.::||::||.|
Zfish    49 DPNFFRMVEGFFDRGASIVEDKLVHDLKTRETPEQKRHRVRGILKIIKPCNHVLSVSFPIKRDNG 113

  Fly   119 NYEMITGYRAQHSTHKTPTKGGIRFSLDVSRDEVKALSALMTFKCACVDVPFGGAKAGLKINPKE 183
            .:|||.|||||||.|:||.|||||:|.:||.||||||::|||:|||.|||||||||||:|||||.
Zfish   114 EWEMIEGYRAQHSQHRTPCKGGIRYSTEVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKN 178

  Fly   184 YSEHELEKITRRFTLELAKKGFIGPGVDVPAPDMGTGEREMSWIADTYAKTIGHLDINAHACVTG 248
            ||:.||||||||||:|||||||||||:|||||||.||||||||||||||.|:||.||||||||||
Zfish   179 YSDTELEKITRRFTIELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYANTMGHHDINAHACVTG 243

  Fly   249 KPINQGGIHGRVSATGRGVFHGLENFINEANYMSQIGTTPGWGGKTFIVQGFGNVGLHTTRYLTR 313
            |||:|||||||:||||||||||:|||:|||.||||:|.|||:|.|||::|||||||||:.|||.|
Zfish   244 KPISQGGIHGRISATGRGVFHGIENFVNEAAYMSQLGLTPGFGDKTFVIQGFGNVGLHSMRYLHR 308

  Fly   314 AGATCIGVIEHDGTLYNPEGIDPKLLEDYKNEHGTIVGYQNAKPYEGENLMFEKCDIFIPAAVEK 378
            .||.|:|:.|.||:::||.|||||.|||||..:||||||..|..||| |::..:|||.||||.||
Zfish   309 YGAKCVGIGELDGSIWNPSGIDPKELEDYKLANGTIVGYPGATAYEG-NILEAECDILIPAASEK 372

  Fly   379 VITSENANRIQAKIIAEAANGPTTPAADKILIDRNILVIPDLYINAGGVTVSFFEWLKNLNHVSY 443
            .:|.:|||.|:||||||.|||||||.||||.::|||:||||:|:||||||||:||||||||||||
Zfish   373 QLTKKNANNIKAKIIAEGANGPTTPEADKIFLERNIMVIPDMYLNAGGVTVSYFEWLKNLNHVSY 437

  Fly   444 GRLTFKYERESNYHLLASVQQSIERIINDESVQESLERRFGRVGGRIPVTPSESFQKRISGASEK 508
            |||||||||:||||||.             ||||||||:||:.||.||:.|:..||:||||||||
Zfish   438 GRLTFKYERDSNYHLLM-------------SVQESLERKFGKHGGAIPIVPTSDFQERISGASEK 489

  Fly   509 DIVHSGLDYTMERSARAIMKTAMKYNLGLDLRTAAYVNSIEKIFTTYRDAGLAF 562
            |||||||.||||||||.||:||.:||||||||||||||:|||:|..|.:|||.|
Zfish   490 DIVHSGLAYTMERSARQIMRTANRYNLGLDLRTAAYVNAIEKVFKVYHEAGLTF 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdh	NP_524470.4	GdhA	98..560	CDD:223411	333/461 (72%)
		ELFV_dehydrog_N	104..233	CDD:280903	98/128 (77%)
		NAD_bind_1_Glu_DH	254..552	CDD:133445	212/297 (71%)
glud1a	NP_997741.1	ELFV_dehydrog_N	99..226	CDD:280903	96/126 (76%)
		ELFV_dehydrog	249..540	CDD:278631	214/304 (70%)
		NAD_bind_1_Glu_DH	249..534	CDD:133445	212/298 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588142
Domainoid	1	1.000	296	1.000	Domainoid score	I1450
eggNOG	1	0.900	-	-		E1_COG0334
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55885
Inparanoid	1	1.050	752	1.000	Inparanoid score	I545
OMA	1	1.010	-	-		QHG54967
OrthoDB	1	1.010	-	-		D217293at33208
OrthoFinder	1	1.000	-	-		FOG0001473
OrthoInspector	1	1.000	-	-		otm25878
orthoMCL	1	0.900	-	-		OOG6_100455
Panther	1	1.100	-	-	O	PTHR11606
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R306
SonicParanoid	1	1.000	-	-		X1737
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	18	18.300