DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gdh and GLUD2

DIOPT Version :9

Sequence 1:	NP_524470.4	Gene:	Gdh / 42832	FlyBaseID:	FBgn0001098	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_036216.2	Gene:	GLUD2 / 2747	HGNCID:	4336	Length:	558	Species:	Homo sapiens

Alignment Length:	570	Identity:	372/570 - (65%)
Similarity:	442/570 - (77%)	Gaps:	25/570 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 YHLKSL--ARQG-------ARRQQELATLAKALPTAVMQSSRGYATEHQIPDRLKDVPTAKDPRF 57
            |..|:|  :|.|       |.....|....:..|.|..|.....|......:.:.|  ...||.|
Human     4 YLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVAD--REDDPNF 66

  Fly    58 FDMVEYFFHRGCQIAEESLVDDMKGKLTRDEKKQKVKGILMLMQPCDHIIEIAFPLRRDAGNYEM 122
            |.|||.||.||..|.|:.||.|::.:.:.::|:.:|:|||.:::||:|::.::||:|||.|::|:
Human    67 FKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEV 131

  Fly   123 ITGYRAQHSTHKTPTKGGIRFSLDVSRDEVKALSALMTFKCACVDVPFGGAKAGLKINPKEYSEH 187
            |.|||||||.|:||.|||||:|.|||.||||||::|||:|||.|||||||||||:|||||.|:|:
Human   132 IEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTEN 196

  Fly   188 ELEKITRRFTLELAKKGFIGPGVDVPAPDMGTGEREMSWIADTYAKTIGHLDINAHACVTGKPIN 252
            ||||||||||:|||||||||||||||||||.||||||||||||||.||||.|||||||||||||:
Human   197 ELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPIS 261

  Fly   253 QGGIHGRVSATGRGVFHGLENFINEANYMSQIGTTPGWGGKTFIVQGFGNVGLHTTRYLTRAGAT 317
            |||||||:||||||||||:|||||||:|||.:|.|||:..|||:||||||||||:.|||.|.||.
Human   262 QGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAK 326

  Fly   318 CIGVIEHDGTLYNPEGIDPKLLEDYKNEHGTIVGYQNAKPYEGENLMFEKCDIFIPAAVEKVITS 382
            ||.|.|.||:::||:|||||.|||:|.:||:|:|:..||||||..|..: |||.||||.||.:|.
Human   327 CIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEVD-CDILIPAATEKQLTK 390

  Fly   383 ENANRIQAKIIAEAANGPTTPAADKILIDRNILVIPDLYINAGGVTVSFFEWLKNLNHVSYGRLT 447
            .||.|::||||||.|||||||.||||.::||||||||||:||||||||:||||||||||||||||
Human   391 SNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLT 455

  Fly   448 FKYERESNYHLLASVQQSIERIINDESVQESLERRFGRVGGRIPVTPSESFQKRISGASEKDIVH 512
            |||||:||||||.             ||||||||:||:.||.||:.|:..||..|||||||||||
Human   456 FKYERDSNYHLLL-------------SVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVH 507

  Fly   513 SGLDYTMERSARAIMKTAMKYNLGLDLRTAAYVNSIEKIFTTYRDAGLAF 562
            |.|.||||||||.||.||||||||||||||||||:|||:|..|.:||:.|
Human   508 SALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTF 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdh	NP_524470.4	GdhA	98..560	CDD:223411	337/461 (73%)
		ELFV_dehydrog_N	104..233	CDD:280903	100/128 (78%)
		NAD_bind_1_Glu_DH	254..552	CDD:133445	213/297 (72%)
GLUD2	NP_036216.2	GdhA	104..555	CDD:223411	340/464 (73%)
		ELFV_dehydrog_N	113..240	CDD:280903	98/126 (78%)
		NAD_bind_1_Glu_DH	263..548	CDD:133445	213/298 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153110
Domainoid	1	1.000	292	1.000	Domainoid score	I1518
eggNOG	1	0.900	-	-		E1_COG0334
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	755	1.000	Inparanoid score	I566
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54967
OrthoDB	1	1.010	-	-		D217293at33208
OrthoFinder	1	1.000	-	-		FOG0001473
OrthoInspector	1	1.000	-	-		otm41717
orthoMCL	1	0.900	-	-		OOG6_100455
Panther	1	1.100	-	-	O	PTHR11606
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R306
SonicParanoid	1	1.000	-	-		X1737
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800