Protein Alignment Gdh and gdh2

DIOPT Version :9

• Sequence 1: NP_524470.4
• Gene: Gdh / 42832
• FlyBaseID: FBgn0001098
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_588149.1
• Gene: gdh2 / 2539148
• PomBaseID: SPCC132.04c
• Length: 1106
• Species: Schizosaccharomyces pombe
• Alignment Length: 682
• Identity: 156/682 - (22%)
• Similarity: 242/682 - (35%)
• Gaps: 204/682 - (29%)

  Fly    18 LATLAKALPTAVMQSSRGYATEHQIPDRLKDVPTAKDPRFFDMVEYFF-------------HR-- 67
            |.|:.:.|.|...       |..:|.|.:...|......|    |.|:             ||
pombe   453 LETIKRRLSTLAF-------TRTKIHDTIMQYPGLVHTLF----EQFYLEHAINHNSTPHLHRAK 506

  Fly    68 -GCQIAEE------------SLVDDMKGKLTRDEKKQKVKGILMLMQPCDHIIEIAF-------- 111
             ...:|:|            :|:|.::...|.:|   .|..:.|.::...|:::..|
pombe   507 SATSLADEASTYSITPMSATALMDLIQKTCTNEE---DVSVMEMFVKFNTHLLKTNFFQTTKVAL 568

  Fly   112 -----PLRRDAGNYE-------MITG--YRAQHSTHKTPTKGGIR---------FSLDVSR--DE 151
                 |...|:..|:       |..|  :|..|...:...:||||         |.|:...  ||
pombe   569 SFRFDPSFLDSTQYKDPLYAMIMSIGNEFRGFHLRFRDVARGGIRLIKSANPEAFGLNARGLFDE 633

  Fly   152 VKALSALMTFKCACVDVPFGGAKAGLKINPKEYSEHELEKITRRFTLELAKKGFIGPGVDV---- 212
            ...|:.....|..  |:|.|||| |:.:..|:..:..          |||...:|...:|:
pombe   634 NYNLAKTQMLKNK--DIPEGGAK-GVILLGKDCQDKP----------ELAFMKYIDSIIDLLIVN 685

  Fly   213 ---PAPDMGTGEREMSWIA--DTYAKTIGHLDINAH--------ACVTGKPINQGGI----HGRV 260
               |..|. .|:.|:.::.  :..|..:....|:||        :..|||....|||    :|..
pombe   686 KSQPLVDK-LGKPEILFMGPDENTADLVNWATIHAHRRNAPWWKSFFTGKKPTMGGIPHDKYGMT 749

  Fly   261 SATGRGVFHGLENFIN--EANYMSQIGTTPGWGGKTFIVQGFGNVGLHTTRYLTRAGATCIGVIE 323
            |.:.|....|:...:|  :.:.::::.|    ||....: |...:.|...:|        |.||:
pombe   750 SLSVRCYVEGIYKKLNITDPSKLTKVQT----GGPDGDL-GSNEIKLSNEKY--------IAVID 801

  Fly   324 HDGTLYNPEGIDPKLLEDYKNEHGTI----------VGYQ------NAKPYEGE----NLMFE-- 366
            ..|.||:|.|:|...|....:|..||          .||:      |.|...||    ..:|.
pombe   802 GSGVLYDPAGLDRTELLRLADERKTIDHFDAGKLSPEGYRVLVKDTNLKLPNGEIVRNGTIFRNT 866

  Fly   367 -----KCDIFIPAA----------VEKVITSENANRIQAKIIAEAANGPTTPAADKILIDRNILV 416
                 |.|.|:|..          ||::|  ::..|...|.:.|.||...|..|..:|....::|
pombe   867 AHLRYKADTFVPCGGRPNAININNVEQLI--DDHGRPAFKYLVEGANLFITQDAKSVLEKAGVIV 929

  Fly   417 IPDLYINAGGVTVSFFEWLKNLNHVSYGRLTFKYERESNYH------LLASVQQSIERIINDESV 475
            |.|...|.||||.|..|.|.:|   |:...:||  .....|      ..|.....::|||
pombe   930 IRDASANKGGVTSSSLEVLASL---SFDDASFK--ENMCVHDGKVPTFYADYVNEVKRII----- 984

  Fly   476 QESLERRF-----GRVGGRIPVTPSESFQKRISGASEKDIVHSGLD-YTME--------RSA--R 524
            |.:....|     |....:||.|       .:|.....:||....| |..|        |:|  |
pombe   985 QRNANLEFEAIWKGHSENKIPYT-------SLSNHLSTEIVKLDHDIYNYEKLWADVGFRNAVLR 1042

  Fly   525 AIMKTAMKYNLGLDLRTAAYVNS-IEKIFTTY 555
            |.:...::..:||:........| :..||:||
pombe  1043 ASIPKTLQAKIGLEKMLERIPESYLRAIFSTY 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gdh	NP_524470.4	GdhA	98..560	CDD:223411	136/574 (24%)
		ELFV_dehydrog_N	104..233	CDD:280903	36/170 (21%)
		NAD_bind_1_Glu_DH	254..552	CDD:133445	88/363 (24%)
gdh2	NP_588149.1	PTZ00324	87..1105	CDD:240359	156/682 (23%)
		Bac_GDH	<556..>655	CDD:304617	24/101 (24%)
		NADB_Rossmann	740..1006	CDD:304358	72/290 (25%)
		ELFV_dehydrog	872..979	CDD:214847	32/113 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0334
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810