DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gdh and gdh-1

DIOPT Version :9

Sequence 1:	NP_524470.4	Gene:	Gdh / 42832	FlyBaseID:	FBgn0001098	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_502267.1	Gene:	gdh-1 / 178130	WormBaseID:	WBGene00014095	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	550	Identity:	330/550 - (60%)
Similarity:	417/550 - (75%)	Gaps:	21/550 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LATLAK-ALPTAVMQSSRGYATEH-QIPDRLKDVPTAKDPRFFDMVEYFFHRGCQIAEESLVDDM 80
            |:||:: |...||...|......| |:.|..|.:....:|.|:.||:::|::|.::....|.:::
Worm     2 LSTLSRGARSVAVRSYSAATLDAHSQVLDEQKPMEEQVNPSFYKMVDFYFNKGAEVIAPKLAEEL 66

  Fly    81 K-GKLTRDEKKQKVKGILMLMQPCDHIIEIAFPLRRDAGNYEMITGYRAQHSTHKTPTKGGIRFS 144
            | ..|::.:||..|.|||..::|.:.::.|.||:|||.|.:|:|..:|||||.|:||||||||:|
Worm    67 KSNSLSQKDKKNLVSGILGAIKPVNKVLYITFPIRRDNGEFEVIEAWRAQHSEHRTPTKGGIRYS 131

  Fly   145 LDVSRDEVKALSALMTFKCACVDVPFGGAKAGLKINPKEYSEHELEKITRRFTLELAKKGFIGPG 209
            |||..|||||||||||:|||.|||||||||.|:||:||:|:::|:||||||..:|.|||||:|||
Worm   132 LDVCEDEVKALSALMTYKCAVVDVPFGGAKGGVKIDPKQYTDYEIEKITRRIAIEFAKKGFLGPG 196

  Fly   210 VDVPAPDMGTGEREMSWIADTYAKTIGHLDINAHACVTGKPINQGGIHGRVSATGRGVFHGLENF 274
            |||||||||||||||.|||||||:||||||.:|.||:|||||..||||||||||||||:.|||.|
Worm   197 VDVPAPDMGTGEREMGWIADTYAQTIGHLDRDASACITGKPIVSGGIHGRVSATGRGVWKGLEVF 261

  Fly   275 INEANYMSQIGTTPGWGGKTFIVQGFGNVGLHTTRYLTRAGATCIGVIEHDGTLYNPEGIDPKLL 339
            .|:|:||..:|...|..|||.|:||||||||||.|||.|||:..||:.|:|..:|||:||.||.|
Worm   262 TNDADYMKMVGLDTGLAGKTAIIQGFGNVGLHTHRYLHRAGSKVIGIQEYDCAVYNPDGIHPKEL 326

  Fly   340 EDYKNEHGTIVGYQNAKPYEG-ENLMFEKCDIFIPAAVEKVITSENANRIQAKIIAEAANGPTTP 403
            ||:|:.:|||..:..||.::. ..||:||||||:|||.||.|..|||:|||||||||||||||||
Worm   327 EDWKDANGTIKNFPGAKNFDPFTELMYEKCDIFVPAACEKSIHKENASRIQAKIIAEAANGPTTP 391

  Fly   404 AADKILIDR-NILVIPDLYINAGGVTVSFFEWLKNLNHVSYGRLTFKYERESNYHLLASVQQSIE 467
            |||:||:.| :.|:|||:|:|:||||||:|||||||||||||||||||:.|:|..||||||:|:.
Worm   392 AADRILLARGDCLIIPDMYVNSGGVTVSYFEWLKNLNHVSYGRLTFKYDEEANKMLLASVQESLS 456

  Fly   468 RIINDESVQESLERRFGRVGGRIPVTPSESFQKRISGASEKDIVHSGLDYTMERSARAIMKTAMK 532
            :                .||...||.|:.:|..:|:||||||||||||:|||:||..||::||.|
Worm   457 K----------------AVGKDCPVEPNAAFAAKIAGASEKDIVHSGLEYTMQRSGEAIIRTAHK 505

  Fly   533 YNLGLDLRTAAYVNSIEKIFTTYRDAGLAF 562
            ||||||:|||||.|||||::.|||.||..|
Worm   506 YNLGLDIRTAAYANSIEKVYNTYRTAGFTF 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdh	NP_524470.4	GdhA	98..560	CDD:223411	302/463 (65%)
		ELFV_dehydrog_N	104..233	CDD:280903	93/128 (73%)
		NAD_bind_1_Glu_DH	254..552	CDD:133445	189/299 (63%)
gdh-1	NP_502267.1	GdhA	75..533	CDD:223411	308/473 (65%)
		ELFV_dehydrog_N	91..218	CDD:280903	91/126 (72%)
		NAD_bind_1_Glu_DH	241..526	CDD:133445	189/300 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I980
eggNOG	1	0.900	-	-		E1_COG0334
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55885
Inparanoid	1	1.050	654	1.000	Inparanoid score	I416
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S1271
OMA	1	1.010	-	-		QHG54967
OrthoDB	1	1.010	-	-		D217293at33208
OrthoFinder	1	1.000	-	-		FOG0001473
OrthoInspector	1	1.000	-	-		oto20718
orthoMCL	1	0.900	-	-		OOG6_100455
Panther	1	1.100	-	-	LDO	PTHR11606
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R306
SonicParanoid	1	1.000	-	-		X1737
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.860