DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gdh and Glud1

DIOPT Version :9

Sequence 1:	NP_524470.4	Gene:	Gdh / 42832	FlyBaseID:	FBgn0001098	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_032159.1	Gene:	Glud1 / 14661	MGIID:	95753	Length:	558	Species:	Mus musculus

Alignment Length:	572	Identity:	372/572 - (65%)
Similarity:	450/572 - (78%)	Gaps:	39/572 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RRQQELATLAKALPTAVMQS----------SRGYATEHQIPDRLKDVPTAK------------DP 55
            ||..|...|::|.|.|:..:          :||..:....|..   .|.|:            ||
Mouse     3 RRLGEALLLSRAGPAALGSAAADSAALLGWARGQPSAAPQPGL---TPVARRHYSEAAADREDDP 64

  Fly    56 RFFDMVEYFFHRGCQIAEESLVDDMKGKLTRDEKKQKVKGILMLMQPCDHIIEIAFPLRRDAGNY 120
            .||.|||.||.||..|.|:.||:|:|.:.:.::|:.:|:|||.:::||:|::.::||:|||.|::
Mouse    65 NFFKMVEGFFDRGASIVEDKLVEDLKTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSW 129

  Fly   121 EMITGYRAQHSTHKTPTKGGIRFSLDVSRDEVKALSALMTFKCACVDVPFGGAKAGLKINPKEYS 185
            |:|.|||||||.|:||.|||||:|.|||.||||||::|||:|||.|||||||||||:|||||.|:
Mouse   130 EVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYT 194

  Fly   186 EHELEKITRRFTLELAKKGFIGPGVDVPAPDMGTGEREMSWIADTYAKTIGHLDINAHACVTGKP 250
            ::||||||||||:|||||||||||:|||||||.||||||||||||||.||||.||||||||||||
Mouse   195 DNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKP 259

  Fly   251 INQGGIHGRVSATGRGVFHGLENFINEANYMSQIGTTPGWGGKTFIVQGFGNVGLHTTRYLTRAG 315
            |:|||||||:||||||||||:|||||||:|||.:|.|||:|.|||:||||||||||:.|||.|.|
Mouse   260 ISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFG 324

  Fly   316 ATCIGVIEHDGTLYNPEGIDPKLLEDYKNEHGTIVGYQNAKPYEGENLMFEKCDIFIPAAVEKVI 380
            |.|:||.|.||:::||:|||||.|||:|.:||:|:|:..||.||| :::...|||.||||.||.:
Mouse   325 AKCVGVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKVYEG-SILEADCDILIPAASEKQL 388

  Fly   381 TSENANRIQAKIIAEAANGPTTPAADKILIDRNILVIPDLYINAGGVTVSFFEWLKNLNHVSYGR 445
            |..||.|::||||||.|||||||.||||.::|||:||||||:||||||||:||||||||||||||
Mouse   389 TKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGR 453

  Fly   446 LTFKYERESNYHLLASVQQSIERIINDESVQESLERRFGRVGGRIPVTPSESFQKRISGASEKDI 510
            |||||||:||||||.             ||||||||:||:.||.|||.|:..||.||||||||||
Mouse   454 LTFKYERDSNYHLLM-------------SVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDI 505

  Fly   511 VHSGLDYTMERSARAIMKTAMKYNLGLDLRTAAYVNSIEKIFTTYRDAGLAF 562
            |||||.||||||||.||:||||||||||||||||||:|||:|..|.:||:.|
Mouse   506 VHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTF 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdh	NP_524470.4	GdhA	98..560	CDD:223411	336/461 (73%)
		ELFV_dehydrog_N	104..233	CDD:280903	98/128 (77%)
		NAD_bind_1_Glu_DH	254..552	CDD:133445	214/297 (72%)
Glud1	NP_032159.1	GdhA	104..546	CDD:223411	335/455 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843208
Domainoid	1	1.000	290	1.000	Domainoid score	I1546
eggNOG	1	0.900	-	-		E1_COG0334
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55885
Inparanoid	1	1.050	753	1.000	Inparanoid score	I566
Isobase	1	0.950	-	0.917438	Normalized mean entropy	S1271
OMA	1	1.010	-	-		QHG54967
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001473
OrthoInspector	1	1.000	-	-		oto94259
orthoMCL	1	0.900	-	-		OOG6_100455
Panther	1	1.100	-	-	LDO	PTHR11606
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R306
SonicParanoid	1	1.000	-	-		X1737
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740