Protein Alignment Rpt2 and AFG3

DIOPT Version :10

• Sequence 1: NP_524469.2
• Gene: Rpt2 / 42828
• FlyBaseID: FBgn0015282
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: NP_010933.1
• Gene: AFG3 / 856737
• SGDID: S000000819
• Length: 761
• Species: Saccharomyces cerevisiae
• Alignment Length: 503
• Identity: 139/503 - (27%)
• Similarity: 223/503 - (44%)
• Gaps: 113/503 - (22%)

  Fly     1 MGQNQSAQGGAGEKKDDKDKKKKYEPPIPTRVGKKKRRAKGPDAAMKLPQVTPHTRCRLKLLKLE 65
            :.:|:..:.|.|:...:||.....|.      ||.||...|                  .|.:..
Yeast    71 LNENRPNKEGEGKNNGNKDNNSNKED------GKDKRNEFG------------------SLSEYF 111

  Fly    66 RIKDY---LMMEDEFIRNQERLKPQDEKNEEERSKV---DDLRGTPMSVGNLEEI---------- 114
            |.|::   :.:...|......|.|....:.::.::|   .|.:...:..|.:.:|
Yeast   112 RSKEFANTMFLTIGFTIIFTLLTPSSNNSGDDSNRVLTFQDFKTKYLEKGLVSKIYVVNKFLVEA 176

  Fly   115 -IDDNHAIVSTSVGS--------EHYVSILSFVDKDQL--------EP--------------GCS 148
             :.:...:||.::||        :....:|:...:|::        .|              |..
Yeast   177 ELVNTKQVVSFTIGSVDIFEEQMDQIQDLLNIPPRDRIPIKYIERSSPFTFLFPFLPTIILLGGL 241

  Fly   149 VLLNHKVHAV-----------------VG-----VLSDDTDPMVTVMKLEKAPQETYADIGGLDT 191
            ..:..|:::.                 ||     :.:.:||..:           ::.::.|.|.
Yeast   242 YFITRKINSSPPNANGGGGGGLGGMFNVGKSRAKLFNKETDIKI-----------SFKNVAGCDE 295

  Fly   192 QIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQ 256
            ..|||.|.|.. |.:|..|.::|.|.|:|.||.|||||||||||||.|.:.:..||.|.|||.::
Yeast   296 AKQEIMEFVHF-LKNPGKYTKLGAKIPRGAILSGPPGTGKTLLAKATAGEANVPFLSVSGSEFVE 359

  Fly   257 KYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNS--GGEREIQRTMLELLNQLDGFD 319
            .::|.|...||:||..|...||||:|||||||:|.:|....:  |...|.:.|:.:||.::|||.
Yeast   360 MFVGVGASRVRDLFTQARSMAPSIIFIDEIDAIGKERGKGGALGGANDEREATLNQLLVEMDGFT 424

  Fly   320 SRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIFTIHTSRMT----LAEDV-NL 379
            :...|.|:..|||.:.||.||:||||.||.|:...||...:::|:.:|..|:.    |.:|: ||
Yeast   425 TSDQVVVLAGTNRPDVLDNALMRPGRFDRHIQIDSPDVNGRQQIYLVHLKRLNLDPLLTDDMNNL 489

  Fly   380 S-ELIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKESVL 426
            | :|.......:||||...|.||.|:|.|.....:|...|:::.|.|:
Yeast   490 SGKLATLTPGFTGADIANACNEAALIAARHNDPYITIHHFEQAIERVI 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpt2	NP_524469.2	PTZ00361	1..439	CDD:185575	139/503 (28%)
AFG3	NP_010933.1	FtsH_ext	124..215	CDD:377663	13/90 (14%)
		FtsH_fam	223..730	CDD:273520	112/327 (34%)