DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rpt2 and KATNAL2

DIOPT Version :9

Sequence 1:	NP_001287493.1	Gene:	Rpt2 / 42828	FlyBaseID:	FBgn0015282	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001340828.1	Gene:	KATNAL2 / 83473	HGNCID:	25387	Length:	564	Species:	Homo sapiens

Alignment Length:	442	Identity:	131/442 - (29%)
Similarity:	204/442 - (46%)	Gaps:	94/442 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KKKKYEPPIPTRVGKKKRRAKGPDAAMKLPQVTPHTRCRLKLLKLERIKDYLMMEDEFIRNQERL 84
            |.:||    |..|.|....|:.     .|||     |.|.|..:        ||.|. .:|..::
Human   108 KFQKY----PKIVKKSSDTAEN-----NLPQ-----RSRGKTRR--------MMNDS-CQNLPKI 149

  Fly    85 KPQDEKNEEERSKVDDLRGTPMSVGNLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLE----P 145
            ..|..:::....|..|.:.......| :|::|      :|.:.|.::...:|.:.||..|    |
Human   150 NQQRPRSKTTAGKTGDTKSLNKEHPN-QEVVD------NTRLESANFGLHISRIRKDSGEENAHP 207

  Fly   146 GCSVLLNHK---VHAVVGVLSD--------DTDPMVTVMKLEKA--------------------- 178
            ....:::.:   ..|:.|..|:        :.||...::|...|
Human   208 RRGQIIDFQGLLTDAIKGATSELALNTFDHNPDPSERLLKPLSAFIGMNSEMRELAAVVSRDIYL 272

  Fly   179 --PQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQ 241
              |...:.||.|||...|.:||:|..|:.:|:.:..: :.|.||::|||||||||||||||||.:
Human   273 HNPNIKWNDIIGLDAAKQLVKEAVVYPIRYPQLFTGI-LSPWKGLLLYGPPGTGKTLLAKAVATE 336

  Fly   242 TSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNSGGERE-IQ 305
            ...||..:..|.::.|:.||..||||.||.:|..||||.:|:||:::|.::| .:.||||.| ..
Human   337 CKTTFFNISASTIVSKWRGDSEKLVRVLFELARYHAPSTIFLDELESVMSQR-GTASGGEHEGSL 400

  Fly   306 RTMLELLNQLDGFDSRGD-VKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEK----------- 358
            |...|||.|:||.....| |.|:.|:|....||.|::|  |::::|...||..:
Human   401 RMKTELLVQMDGLARSEDLVFVLAASNLPWELDCAMLR--RLEKRILVDLPSREARQAMIYHWLP 463

  Fly   359 --TKRRIFTIHTSRMTLAEDVNLSELIMAKDDLSGADIKAICTEAGLMALRE 408
              :|.|...:||       ::..|.|....:..||:|||.:|.||.:..:|:
Human   464 PVSKSRALELHT-------ELEYSVLSQETEGYSGSDIKLVCREAAMRPVRK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt2	NP_001287493.1	PTZ00361	1..439	CDD:185575	131/442 (30%)
KATNAL2	NP_001340828.1	LisH	51..81	CDD:128913
KATNAL2	NP_001340828.1	SpoVK	<264..559	CDD:223540	94/256 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810