DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rpt2 and Atad2

DIOPT Version :9

Sequence 1:	NP_001287493.1	Gene:	Rpt2 / 42828	FlyBaseID:	FBgn0015282	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_081711.2	Gene:	Atad2 / 70472	MGIID:	1917722	Length:	1364	Species:	Mus musculus

Alignment Length:	488	Identity:	137/488 - (28%)
Similarity:	221/488 - (45%)	Gaps:	126/488 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GQNQSAQGGA------GEKKDDKDKKK------------------KYEPPIPTRVGKKKRRAKGP 42
            |..:|::.|.      ||.:||:|:::                  .|:.|:.:    |.|..:.|
Mouse   238 GSVESSEEGEEQEDDDGEDEDDEDEEEGEEDNQKRYYLRQRKTTVYYQSPLES----KPRHQRKP 298

  Fly    43 DAAMKLPQVTPHTRCRLK--------LLKLERIKDYLMMEDEFIRNQERLKPQDEKNEEERSKV- 98
            :.....|......|.||.        ..::.|.:..:...|....:.......:.:.:..|::.
Mouse   299 NMFYSGPASPARPRFRLSSTGPRSPYCKRMSRRRHAIHSSDSTSSSSSEDDCFERRTKRNRNRAI 363

  Fly    99 ----------DDLRGTPMSVGNLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEPGCSVLLNH 153
                      |::||                                  :.||:::.|.|:.
Mouse   364 NRCLPLNFRKDEIRG----------------------------------IYKDRMKIGASLA--- 391

  Fly   154 KVHAVVGVLSDDTDPMVTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGIKPP 218
                       |.||    |:|:.:.:  :..:|||.:.|..:||.|..||.:||.:|:..|:||
Mouse   392 -----------DVDP----MQLDTSVR--FDSVGGLSSHIAALKEMVVFPLLYPEVFEKFKIQPP 439

  Fly   219 KGVILYGPPGTGKTLLAKAVANQTS------ATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHA 277
            :|.:.||||||||||:|:|:||:.|      |.|:| .|::.:.|::|:..:.:|.||..|.:..
Mouse   440 RGCLFYGPPGTGKTLVARALANECSRGDKRVAFFMR-KGADCLSKWVGESERQLRLLFDQAYQMR 503

  Fly   278 PSIVFIDEIDAVGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIR 342
            |:|:|.||||.:...|..........|..|:|.|   :||.||||::.||.||||::::||||.|
Mouse   504 PAIIFFDEIDGLAPVRSSRQDQIHSSIVSTLLAL---MDGLDSRGEIVVIGATNRLDSIDPALRR 565

  Fly   343 PGRIDRKIEFPLPDEKTKRRIFTIHTSRMTLAEDVNLSELIMAKDDLS-------GADIKAICTE 400
            |||.||:..|.|||:..::.|..|||      .|.|...:.|..::|:       |||||:||.|
Mouse   566 PGRFDREFLFSLPDKNARKEILKIHT------RDWNPKPVDMFLEELAEHCVGYCGADIKSICAE 624

  Fly   401 AGLMALRER--RMKVTNEDFKKSKESVLYRKKE 431
            |.|.|||.|  ::..|:|..:....|:....|:
Mouse   625 AALCALRRRYPQIYTTSEKLQLDLSSITISAKD 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rpt2	NP_001287493.1	PTZ00361	1..439	CDD:185575	137/488 (28%)
Atad2	NP_081711.2	AAA	438..579	CDD:214640	64/144 (44%)
		AAA	443..577	CDD:278434	60/137 (44%)
		Bromo_AAA	960..1070	CDD:99957
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0554
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900