DRSC/TRiP Functional Genomics Resources

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Protein Alignment Rpt2 and PSMC4

DIOPT Version :10

Sequence 1:NP_524469.2 Gene:Rpt2 / 42828 FlyBaseID:FBgn0015282 Length:439 Species:Drosophila melanogaster
Sequence 2:NP_006494.1 Gene:PSMC4 / 5704 HGNCID:9551 Length:418 Species:Homo sapiens


Alignment Length:399 Identity:195/399 - (48%)
Similarity:290/399 - (72%) Gaps:13/399 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 GPDAAMKLPQVTPHTRCRLKLLKLERIKDYLMMEDEFIRN-QERLKPQDEKNEEERSKVDDLRGT 104
            ||:     |:.......|.|  ||::..::|.:::|:|:: |:.||.:....:||..::..:   
Human    31 GPE-----PEDLEDLYSRYK--KLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSI--- 85

  Fly   105 PMSVGNLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEPGCSVLLNHKVHAVVGVLSDDTDPM 169
            |:.:|...|.:|.|.|||.::.||.:||.|||.:|::.|:|..||.|:...:|:|.||..:.|..
Human    86 PLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSS 150

  Fly   170 VTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLL 234
            :.::..::.|...||||||:|.|.||::|:|||||||.|.|:::||.||:||::|||||.|||:|
Human   151 IMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTML 215

  Fly   235 AKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNSG 299
            |||||:.|:|.|:||||||.:|||||:||::||::||:|:|:||:|:|||||||:.|||:|:.:|
Human   216 AKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTG 280

  Fly   300 GEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIF 364
            .:||:||.:||||||:||||...:|||||||||.:||||||:||||:||||||||||.:.||.||
Human   281 ADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIF 345

  Fly   365 TIHTSRMTLAEDVNLSELIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKESVLYRK 429
            :..||:|.|:|:|:|.:.:...|.:|||||.:||.|:|::|:||.|..|..:||:|:.::|:  |
Human   346 STITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVI--K 408

  Fly   430 KEGTPEGLY 438
            |:......|
Human   409 KDEQEHEFY 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Rpt2NP_524469.2 PTZ00361 1..439 CDD:185575 195/399 (49%)
PSMC4NP_006494.1 PTZ00454 34..418 CDD:240423 193/391 (49%)

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