Protein Alignment Rpt2 and YME1L1

DIOPT Version :10

• Sequence 1: NP_524469.2
• Gene: Rpt2 / 42828
• FlyBaseID: FBgn0015282
• Length: 439
• Species: Drosophila melanogaster
• Sequence 2: NP_647473.1
• Gene: YME1L1 / 10730
• HGNCID: 12843
• Length: 773
• Species: Homo sapiens
• Alignment Length: 406
• Identity: 117/406 - (28%)
• Similarity: 199/406 - (49%)
• Gaps: 45/406 - (11%)

  Fly    54 HTRCRLKLLKLERIKDYLMMEDEFIRNQ---------ERLKPQDEKNEEERSKVDD------LRG 103
            |:|.      |:.|...|.....||:::         .||:...|:..|.::....      ||.
Human   185 HSRA------LQSICSDLQYWPVFIQSRGFKTLKSRTRRLQSTSERLAETQNIAPSFVKGFLLRD 243

  Fly   104 TPMSVGNLEEI-----IDDNHAIVSTSVGSEHYVSILSFVDK--DQLEPGCSVLLNHKVHAVVGV 161
            ....|.:|:::     |.:.|.....:..:|.::...:...|  |.|.....:|....:..:.|:
Human   244 RGSDVESLDKLMKTKNIPEAHQDAFKTGFAEGFLKAQALTQKTNDSLRRTRLILFVLLLFGIYGL 308

  Fly   162 LSD-----------DTDPMVTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGI 215
            |.:           ..|..|..::::..   |:..:.|::...||::|.||. |.:|:.:..:|.
Human   309 LKNPFLSVRFRTTTGLDSAVDPVQMKNV---TFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGG 369

  Fly   216 KPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSI 280
            |.|||::|.|||||||||||:|||.:....|....|||..:.::|.|...:|.|||.|:.:||.:
Human   370 KLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCV 434

  Fly   281 VFIDEIDAVGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGR 345
            :||||:|:||.||.:|..  ....::|:.:||.::|||.....|.:|.|||..|.||.|||||||
Human   435 IFIDELDSVGGKRIESPM--HPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGR 497

  Fly   346 IDRKIEFPLPDEKTKRRIFTIHTSRMTLAEDVNLSELIMAKDDLSGADIKAICTEAGLMALRERR 410
            .|.::..|.||.|.:..|...:.:::...:.|:...:.......|||:::.:..:|.|.|..:.:
Human   498 FDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGK 562

  Fly   411 MKVTNEDFKKSKESVL 426
            ..||.::.:.||:.:|
Human   563 EMVTMKELEFSKDKIL 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rpt2	NP_524469.2	PTZ00361	1..439	CDD:185575	117/406 (29%)
YME1L1	NP_647473.1	HflB	<332..767	CDD:440233	91/253 (36%)