Protein Alignment Ndc1 and NDC1

DIOPT Version :10

• Sequence 1: NP_651191.1
• Gene: Ndc1 / 42825
• FlyBaseID: FBgn0039125
• Length: 578
• Species: Drosophila melanogaster
• Sequence 2: NP_013681.1
• Gene: NDC1 / 854977
• SGDID: S000004493
• Length: 655
• Species: Saccharomyces cerevisiae
• Alignment Length: 671
• Identity: 121/671 - (18%)
• Similarity: 231/671 - (34%)
• Gaps: 235/671 - (35%)

  Fly     7 SNACK---------LLLLGRCLRAVLLS-----------VAIQFL-----LLTVFLLFV------ 40
            |:.||         |..:...::.|::|           :|:.|:     |..|.||.:
Yeast    20 SDVCKTRFNHLVTRLFFICSIIQTVVISLLALPHSPLWELALAFIPNILALNLVSLLIIVTRKNY 84

  Fly    41 ----NFQLLHPLAWVTGTLRLVASWYTWFASIPLVASVVL---YGVILCQQHLSERRYCPTRYRW 98
                ||...:.|.::.|  :|::..:..:..:..:.|::|   .||:..:....          |
Yeast    85 MHVKNFGFANSLTFILG--QLLSVKFLVYQGVYSMGSILLSFVLGVVFGRGGSG----------W 137

  Fly    99 LLHYGPRKVLFLFAHLLVGLLTAWLYTGYLH-TDYQHLKYKCYGQDCISAYNVYLLGIGMTAGCY 162
            ..:|          .|.:.|:...:|....| ||...|.:.|  ::...|...|:|
Yeast   138 KPYY----------KLFIWLVVPTIYNLQHHVTDADKLSFNC--ENFFQAPQDYVL--------- 181

  Fly   163 YFVSVHMRKEISIEFPIVEQSRAEKMRELLYASLAKSLLSSLLPTISYTAVFCLFGPMVCHRLSH 227
                                   |:::.::..|:..|::|..:..| :|.||
Yeast   182 -----------------------ERVKRIMEKSVILSVISMFVLPI-FTTVF------------- 209

  Fly   228 ILSVDMDERLDGFF-----GV--VTNVRLLFYGYLLTAQILS---NMHL-MRCFY-GILLSEDLP 280
                 ...:..|.|     ||  |||:.::.....:|.:.::   :.|: :.|.: |.|:|.
Yeast   210 -----FSRQKSGLFDSFTNGVLAVTNLLIISCIIFITFEFINIAFDAHMSIGCLHKGKLISN--- 266

  Fly   281 LVVTKPRAAFAHEQDITLVAGLGVFNVYVVQCLAAHHFYKLALRKNS--PQ-RAEIFQLTEPGNR 342
             :.:.|..        ||::||.....:.  .|.|  :.:||.|..|  |. ||.|:......:.
Yeast   267 -LSSTPME--------TLLSGLSADKPFT--RLTA--YQELAYRATSLDPSLRAPIYHSKFRSSS 318

  Fly   343 PASWRSLCDQCLSILGSFTEELTESMQKISILKCAQSLPMPKITESLTTSLMAEKVLLRQYNQK- 406
            ..:|..:.::||..:....|::.:.::.:..|..:.:....|..|:|  ..|.|...|...|::
Yeast   319 GNTWSLILNECLKTIQINNEKVVQYLRSVQDLGGSATARHKKKVENL--DYMYENGKLTSANERL 381

  Fly   407 HGIRP-IVSPSREVAV--ESP-------ADGI--------RH----------------------- 430
            .|.|| :::|.|:..:  |||       .|.:        ||
Yeast   382 FGNRPSMMAPLRDNGLLDESPNRLRVRTDDSVLLNRGNKKRHRSSYYDNDLDETTQTFNGSIFTH 446

  Fly   431 -----------------------FPNWCERVSTQLEQSLQRLL-----QRVPGIVYLFNEPEGAK 467
                                   ||::.||.|:. |....|||     :....|:.:::..:..:
Yeast   447 ETTFMTAMRLMLKKLKNSIMSFIFPSYAERQSSD-ESDNYRLLPNGSNKAQISIIDIWSISKKRQ 510

  Fly   468 TTFLLANSLPVVYMTQ--ALAQVCAASLKEDPYGVVQNDLPAIIKAINKLRNELDKLSSVIGNI- 529
            ...|:  .||:.:...  ||..:...|..|||.|       .||.::..:...|::....:|..
Yeast   511 AEKLV--PLPICHANSVVALTGLLIRSKTEDPKG-------GIIASVGDILKTLERSICALGEFA 566

  Fly   530 -----RISSSSFNVLRCAVRR 545
                 .::.::|...|.|..|
Yeast   567 DWDPESMAYTAFQTQRTAQDR 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ndc1	NP_651191.1	Ndc1_Nup	63..572	CDD:462824	104/580 (18%)
NDC1	NP_013681.1	Ndc1_Nup	21..640	CDD:462824	120/670 (18%)