Protein Alignment sba and MBD5

DIOPT Version :10

• Sequence 1: NP_001262888.1
• Gene: sba / 42824
• FlyBaseID: FBgn0016754
• Length: 1606
• Species: Drosophila melanogaster
• Sequence 2: NP_001425783.1
• Gene: MBD5 / 55777
• HGNCID: 20444
• Length: 1740
• Species: Homo sapiens
• Alignment Length: 1852
• Identity: 371/1852 - (20%)
• Similarity: 565/1852 - (30%)
• Gaps: 740/1852 - (39%)

  Fly   251 GWRRLTNNNEVAYISPSGKTLRTQFQIKDYLLTQGTCKCGLPCPLRPEYLFDFN----------- 304
            ||:|..:.|.|.|:||||..|....|:|.||||.|||||||.|||....:|:|:
Human    24 GWQRRVDQNGVLYVSPSGSLLSCLEQVKTYLLTDGTCKCGLECPLILPKVFNFDPGAAVKQRTAE 88

  Fly   305 -----------------------------AQVPNQPLKLPTEASTATP-------TP-------- 325
                                         |..|:..|..|...:.|||       ||
Human    89 DVKADEDVTKLCIHKRKIIAVATLHKSMEAPHPSLVLTSPGGGTNATPVVPSRAATPRSVRNKSH 153

  Fly   326 ----------CRHQRRFL--ESQQL------QLPQQQQQQQHLQHQQQQQQAVKDVSVDVAVSVS 372
                      |::..:.:  .|..:      :||..|||:.|..:.:|:          :..|..
Human   154 EGITNSVMPECKNPFKLMIGSSNAMGRLYVQELPGSQQQELHPVYPRQR----------LGSSEH 208

  Fly   373 GPAAVSDVFSTLMTSTARTATMVTPTAATSPAQAATTTTHEMANKDADCHKYGNNKLPATNRTAT 437
            |..:........:.|.|.:.:.:....:.||......:.......:...|...|:.....|||..
Human   209 GQKSPFRGSHGGLPSPASSGSQIYGDGSISPRTDPLGSPDVFTRSNPGFHGAPNSSPIHLNRTPL 273

  Fly   438 TPTPAPTPPPQHPNGMPTSQALALGG---VPVGVHPKRPTGGHVIKQPASVL------------- 486
                  :||....:|.|...:.|:.|   :|:.  |...|...|:|:|....
Human   274 ------SPPSVMLHGSPVQSSCAMAGRTNIPLS--PTLTTKSPVMKKPMCNFSTNMEIPRAMFHH 330

  Fly   487 ----GPPCTPPLAVGGANTVIQQQQPLQQHPNFKDDPAGYLQQQTALLHNSLGVGLDATKTAAGT 547
                |||..||      .:...|::||..    :.||.|.|.                      .
Human   331 KPPQGPPPPPP------PSCALQKKPLTS----EKDPLGILD----------------------P 363

  Fly   548 STARALPQEPIV------HSSQQQQQQQQQ--------QLQQQQQLQRQK---------IRRLSL 589
            ..::.:.|.|::      ||:...|.....        .|.....|...|         ::|:..
Human   364 IPSKPVNQNPVIINPTSFHSNVHSQVPMMNVSMPPAVVPLPSNLPLPTVKPGHMNHGSHVQRVQH 428

  Fly   590 FGKWETDPAPATNSQPTNGTRALQVDAAAFARPQKPQVTCVTLVPPPQESPVSSSAAETLEKRPE 654
            .......|:|.|:.....||...:::|:                  ||.|..||::::.......
Human   429 SASTSLSPSPVTSPVHMMGTGIGRIEAS------------------PQRSRSSSTSSDHGNFMMP 475

  Fly   655 QVGAISTSH------ESPRQSLSSPTDSVDSAKS-------------------------TPSASP 688
            .||..:||.      .|||.::.||..|:.|:.|                         |||::.
Human   476 PVGPQATSSGIKVPPRSPRSTIGSPRPSMPSSPSTKSDGHHQYKDIPNPLIAGISNVLNTPSSAA 540

  Fly   689 KP-----QTQVPMQPQLLQM------RPHLQANLSAQTPVTVPAHVRVMRQQQAQIIPGQRLPVA 742
            .|     .:.|..||.||.|      ..|..|:..|.:.::..|..::..|.:   :.|.....:
Human   541 FPTASAGSSSVKSQPGLLGMPLNQILNQHNAASFPASSLLSAAAKAQLANQNK---LAGNNSSSS 602

  Fly   743 SSSAAMATMTRSIVTSTAGTSTI-------------TG-------------------------RP 769
            |:|.|:|..     .:|.|.||:             ||                         :|
Human   603 SNSGAVAGS-----GNTEGHSTLNTMFPPTANMLLPTGEGQSGRAALRDKLMSQQKDALRKRKQP 662

  Fly   770 VATTLN-------------------------NSNP--TVAQ-LQSM--------ANAMNGAGGGG 798
            ..|.|:                         .|.|  :::| ||||        :|:..|.|...
Human   663 PTTVLSLLRQSQMDSSAVPKPGPDLLRKQGQGSFPISSMSQLLQSMSCQSSHLSSNSTPGCGASN 727

  Fly   799 QLIMTSSGQL-LVIPTPSKQTTQ---------------------------HHRPGQPGQ------ 829
            ..:..|:.|| ...|:.:....|                           ||..|...|
Human   728 TALPCSANQLHFTDPSMNSSVLQNIPLRGEAVHCHNANTNFVHSNSPVPNHHLAGLINQIQASGN 792

  Fly   830 -GVIIQQQQPA--ELHPQPGGGYIVSQPSPV---------------AAASSSSSS---------- 866
             |::.|.....  .|||.|....|.:..:||               |..|..|||
Human   793 CGMLSQSGMALGNSLHPNPPQSRISTSSTPVIPNSIVSSYNQTSSEAGGSGPSSSIAIAGTNHPA 857

  Fly   867 ---STVILNSGGAKLLHHQIITSQAGQINQ---------------------ATSGGSGNQPQTV- 906
               :|.:|..|       .|:|:.||...|                     :.|..:.:.|..:
Human   858 ITKTTSVLQDG-------VIVTTAAGNPLQSQLPIGSDFPFVGQEHALHFPSNSTSNNHLPHPLN 915

  Fly   907 --LLNTLP-----NGGYIVQQ------QPQT---------------------------------- 924
              ||::||     |..:::.|      ||..
Human   916 PSLLSSLPISLPVNQQHLLNQNLLNILQPSAGEGKSEINLHPLGFLNPNVNAALAFLSSDMDGQV 980

  Fly   925 -------------QSPQQAEQILAMPQ--------------PPPAQTLIISSPD-------TKRR 955
                         |:..||..:|.:|.              |.|:.|.:.:.||       ...|
Human   981 LQPVHFQLLAALLQNQAQAAAMLPLPSFNLTISDLLQQQNTPLPSLTQMTAPPDHLPSNQSDNSR 1045

  Fly   956 ARKRKSSVCHTPPPS--GS---------PA-------KIISPQISPSIPNQAPA--LLHQQAAAA 1000
            |....:|....|.||  ||         ||       ..::||:...:.|.|.|  ..|.:.:.|
Human  1046 AETLLTSPLGNPLPSFAGSDTTFNPLFLPAVNGASGLMTLNPQLLGGVLNSASANTANHPEVSIA 1110

  Fly  1001 --------------AAAA----------------------------------------PQFQQQF 1011
                          |.||                                        ||.....
Human  1111 TSSQATTTTTTTSSAVAALTVSTLGGTAVVSMAETLLNISNNAGNTPGPAKLNSNSVVPQLLNPL 1175

  Fly  1012 QLSPGIQG--------------------IVVNKPNPPQQPQTQQLLLQNGQILQQVNLIGQQLL- 1055
             |..|:.|                    :..|:..||.|.|.|  |||..|.||...  ||..:
Human  1176 -LGTGLLGDMSSINNTLSNHQLTHLQSLLNNNQMFPPNQQQQQ--LLQGYQNLQAFQ--GQSTIP 1235

  Fly  1056 MPAG------------LVMGPDATLL--QIQNMPATSLMTPQGPVMLRTP---SPQNKPSFISPS 1103
            .||.            :.|..||.||  :|...|..:.: |:.|.....|   :|......|.||
Human  1236 CPANNNPMACLFQNFQVRMQEDAALLNKRISTQPGLTAL-PENPNTTLPPFQDTPCELQPRIDPS 1299

  Fly  1104 AGGQ---QYLVGANGQLSPIGQIYSTPMGLVMPTGQQGGASFVQASPTTTTIQIQQQPAPQPTQI 1165
            .|.|   ..:||..|..| :..||..    |:....:|....:..:..:||   |..|.|..:.:
Human  1300 LGQQVKDGLVVGGPGDAS-VDAIYKA----VVDAASKGMQVVITTAVNSTT---QISPIPALSAM 1356

  Fly  1166 SL------QPAQATYMTETVMSRQGTAASPPDTTTCSPRSPERPSS-------HRSSGSD---MV 1214
            |.      .|...:.....|:..:.......|....:.|....|.:       :...|.:   ..
Human  1357 SAFTASIGDPLNLSSAVSAVIHGRNMGGVDHDGRLRNSRGARLPKNLDHGKNVNEGDGFEYFKSA 1421

  Fly  1215 QC-VSSSEPDAAVSPQSTESR-------QSPS---STDC-ERSICKNNVFTQP------------ 1255
            .| .|..:.|...||:...:|       ..|.   |:.| ||   .|||.|.|
Human  1422 SCHTSKKQWDGEQSPRGERNRWKYEEFLDHPGHIHSSPCHER---PNNVSTLPFLPGEQHPILLP 1483

  Fly  1256 ---------------SGIYKHSEPKIR-RIHITSQTSAE-NGISLMQGQESPTTTQLLSSV---- 1299
                           ...||.:....: |:..|.:..|. ||   .:.::|....:|||:.
Human  1484 PRNCPGDKILEENFRYNNYKRTMMSFKERLENTVERCAHING---NRPRQSRGFGELLSTAKQDL 1545

  Fly  1300 ------PTAQPTVEKTTVR----------TPTKRSRRPQRGAARAAPSASDKSFP---------- 1338
                  |::..::|.:.|:          ..:.....|....|::..|..|...|
Human  1546 VLEEQSPSSSNSLENSLVKDYIHYNGDFNAKSVNGCVPSPSDAKSISSEDDLRNPDSPSSNELIH 1610

  Fly  1339 LPPRSFAIGELIWGPARGHPAWPGKIVKMPD--GVCTPSQQFDHVWVQWFGGGGRSTSELIPVNS 1401
            ..||:|.:|:|:||..:|..:||||:|:..|  ..|..|.:...|||.||   |..|...:....
Human  1611 YRPRTFNVGDLVWGQIKGLTSWPGKLVREDDVHNSCQQSPEEGKVWVMWF---GLHTFTQVEPEK 1672

  Fly  1402 LQSLSEGLEAHHKAQKDTRKSRKLNSQLERAIQEAMTELDNISASSTPAATSSSSATISAVPASA 1466
            |::|:|||||:.:.:|..|||.|||:.||.||.|||:|||.:            |.|:..:|
Human  1673 LKTLTEGLEAYSRVRKRNRKSGKLNNHLEAAIHEAMSELDKM------------SGTVHQIP--- 1722

  Fly  1467 GPAVIGGQQQYQQQQQQQQQQQSPSSTNNKIN 1498
                           |..:|.:.|.....||:
Human  1723 ---------------QGDRQMRPPKPKRRKIS 1739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sba	NP_001262888.1	MBD	241..315	CDD:128673	32/103 (31%)
		PWWP_MBD5	1344..1441	CDD:438969	43/98 (44%)
MBD5	NP_001425783.1	None