DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sba and DNMT3A

DIOPT Version :9

Sequence 1:	NP_001262888.1	Gene:	sba / 42824	FlyBaseID:	FBgn0016754	Length:	1606	Species:	Drosophila melanogaster
Sequence 2:	NP_072046.2	Gene:	DNMT3A / 1788	HGNCID:	2978	Length:	912	Species:	Homo sapiens

Alignment Length:	542	Identity:	111/542 - (20%)
Similarity:	177/542 - (32%)	Gaps:	177/542 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   983 PSIPNQAPALLHQQAAAAAAAAPQFQQQFQLSPGIQGIVVNKPNPPQQPQTQQLLLQNGQILQQV 1047
            |::|:..|......||.........::|                  ::|:.::...:.....::|
Human     2 PAMPSSGPGDTSSSAAEREEDRKDGEEQ------------------EEPRGKEERQEPSTTARKV 48

  Fly  1048 NLIGQQLLMPAGLVMGPDATLLQIQNMPATSLMTPQGP-VMLRTPSPQNKPSFISPSAGGQQYLV 1111
            ...|::...|                 |..|..||:.| |:.::||       ::..:|..:.|
Human    49 GRPGRKRKHP-----------------PVESGDTPKDPAVISKSPS-------MAQDSGASELL- 88

  Fly  1112 GANGQL-----------SPIGQIYSTPMGLVMPTGQQGGASFVQASPTTTTIQIQQQPAPQPTQI 1165
             .||.|           ||.|             ||:|||
Human    89 -PNGDLEKRSEPQPEEGSPAG-------------GQKGGA------------------------- 114

  Fly  1166 SLQPAQATYMTETVMSRQGTAASPPDTTTCSPRSPERPSSHRSSGSDMVQC-VSSSEPDAAVS-- 1227
               ||:.....||:..    |:...:...|:|:  |...:...:|.:..:. :.|.:.:.:..
Human   115 ---PAEGEGAAETLPE----ASRAVENGCCTPK--EGRGAPAEAGKEQKETNIESMKMEGSRGRL 170

  Fly  1228 ------PQSTESRQSPSSTDCERSICKNNVFTQPSGIYKHSEPK----IRRIHITSQTSAE--NG 1280
                  ..|...|..|..|            .|....|..|:.|    :.|....::..|:  .|
Human   171 RGGLGWESSLRQRPMPRLT------------FQAGDPYYISKRKRDEWLARWKREAEKKAKVIAG 223

  Fly  1281 ISLMQGQESPTTTQLL--SSVPTA-QPT--VEKTTVRTPTKRSRRP---QRGAARAAPSASDKSF 1337
            ::.::..:.|..:|.:  :|.|.. |||  ...|...||     .|   ..|...|..:..|:..
Human   224 MNAVEENQGPGESQKVEEASPPAVQQPTDPASPTVATTP-----EPVGSDAGDKNATKAGDDEPE 283

  Fly  1338 PLPPRSFAIGELIWGPARGHPAWPGKIV--------KMPDGVCTPSQQFDHVWVQWFGGGGRSTS 1394
            ....|.|.||||:||..||...|||:||        :..:|.         .||.|||.|..|
Human   284 YEDGRGFGIGELVWGKLRGFSWWPGRIVSWWMTGRSRAAEGT---------RWVMWFGDGKFS-- 337

  Fly  1395 ELIPVNSLQSLSEGLEAHHKAQKDTRKSRKLNSQ--LERAIQEAMTELDNISASSTPAA-TSSSS 1456
             ::.|..|..||....|.|:|        ..|.|  ..:||.|.:....:.:....|.. .|..|
Human   338 -VVCVEKLMPLSSFCSAFHQA--------TYNKQPMYRKAIYEVLQVASSRAGKLFPVCHDSDES 393

  Fly  1457 ATISAVPASAGPAV---IGGQQ 1475
            .|..||.....|.:   :||.|
Human   394 DTAKAVEVQNKPMIEWALGGFQ 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sba	NP_001262888.1	MBD	241..315	CDD:128673
sba	NP_001262888.1	PWWP	1344..1440	CDD:295359	34/105 (32%)
DNMT3A	NP_072046.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..178		41/266 (15%)
		BASP1	<11..156	CDD:330577	37/235 (16%)
		Interaction with DNMT1 and DNMT3B. /evidence=ECO:0000269\|PubMed:12145218	199..403		60/228 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..286		15/69 (22%)
		Dnmt3b_related	290..376	CDD:99896	34/105 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..466
		ADDz_Dnmt3a	487..614	CDD:277255
		Interaction with the PRC2/EED-EZH2 complex. /evidence=ECO:0000250\|UniProtKB:O88508	494..586
		Dcm	632..>795	CDD:223348
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269\|PubMed:17713477, ECO:0007744\|PDB:2QRV	641..645
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269\|PubMed:17713477, ECO:0007744\|PDB:2QRV	686..688
		S-adenosyl-L-methionine binding. /evidence=ECO:0000269\|PubMed:17713477, ECO:0007744\|PDB:2QRV	891..893
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S8329
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950