Protein Alignment sba and Mbd6

DIOPT Version :10

• Sequence 1: NP_001262888.1
• Gene: sba / 42824
• FlyBaseID: FBgn0016754
• Length: 1606
• Species: Drosophila melanogaster
• Sequence 2: NP_149063.2
• Gene: Mbd6 / 110962
• MGIID: 106378
• Length: 1005
• Species: Mus musculus
• Alignment Length: 1238
• Identity: 272/1238 - (21%)
• Similarity: 388/1238 - (31%)
• Gaps: 376/1238 - (30%)

  Fly   233 NGNINRKTATSYNGNLAP-------GWRRLTNNNEVAYISPSGKTLRTQFQIKDYLLTQGTCKCG 290
            ||: |..:|....|..|.       ||:|......|.||||||..|.:..|.:.|||:.||||||
Mouse     2 NGD-NASSAADRAGGPAATPVPIPIGWQRCVREGAVYYISPSGTELSSLEQTRSYLLSDGTCKCG 65

  Fly   291 LPCPLRPEYLFDFNAQVPNQPLKL---PTEASTATPTPCRHQRRFLESQQLQLPQQQQQQQHLQH 352
            |.|||....:|:|:...|..|...   |......|.. |.|:|:.:....|
Mouse    66 LECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKL-CNHRRKAVAMATL-------------- 115

  Fly   353 QQQQQQAVKDVSVDVAVSVSGPAAVSDVFSTLMTSTARTATMVTPTAATSPAQAATTTTHEMANK 417
                   .:.:....:.|..|..|...:|.|:...         |.:...|.:|..||
Mouse   116 -------YRSMETTCSHSSPGEGASPQMFHTVSPG---------PPSVRPPCRAPPTT------- 157

  Fly   418 DADCHKYGNNKLPATNRTATTPTPAPT---------------PPPQHPNGMPTSQALALGGVPVG 467
                        |......:.|...|:               |||:.|:.:|::.:.:...:|.|
Mouse   158 ------------PLNGGPGSIPQDPPSVPQAFPPLTGPAGLFPPPRLPDPVPSAGSSSPCFLPRG 210

  Fly   468 VHPKRPTGGHVIKQPASVLGPPCTPPLAVG--------GA---NTVIQQQQPLQQHPNFKDDPAG 521
            ..|          .||    ||  ||.|:.        ||   :.::.........|:....|
Mouse   211 NAP----------SPA----PP--PPPAISLNAPSYNWGASLRSNLVPSDLGSPPAPHASSSP-- 257

  Fly   522 YLQQQTALLHNSLGVGLDATKTAAGTSTARALPQEPIVHSSQQQQQQQQQQLQQQQQLQRQKIRR 586
              ...:.|.|.|                 .||...|:..|:.....
Mouse   258 --PSDSPLFHCS-----------------DALTSPPLPPSNNPPGP------------------- 284

  Fly   587 LSLFGKWETDPAPATNSQPTNGTRALQV------DAAAFARPQKPQVTCVTL--------VPPPQ 637
                   ...|.|||....::.|..|.:      .|.|...|..|.....:|        :|||
Mouse   285 -------PGPPGPATQPPVSSATMHLPLVLGSLGGAPAVEGPGAPPFLASSLLSAAAKAQLPPP- 341

  Fly   638 ESPVSSSAAETLEKRPEQVGAISTSHESPRQSLSSPT-----------DSVDSAKSTPSASPKPQ 691
                     .||:.|..:..|.|.:|.|||.|...|.           ....:.:.|...:|.|.
Mouse   342 ---------STLQGRRPRAQAPSAAHASPRPSQRRPRRPPTVLRLLEGGGPQTPRRTRPRAPAPV 397

  Fly   692 TQ-----VPMQPQLLQMRPHLQANLSAQTPVTVPAHVR---VMRQQQAQIIPGQRLPVASSSAAM 748
            .|     .|.||.|    |.:.:.|...||  .|:|..   .:....|.:.|    |.|.||.:.
Mouse   398 PQPFPLPEPSQPIL----PSVLSLLGLPTP--GPSHSDGSFNLLGSDAHLPP----PPALSSGSP 452

  Fly   749 ATMTRSIVTSTAGT-----STITGRPVATTLNNSNPTVAQ--LQSMANAMN-GAGGGGQLIMTSS 805
            ......|..|..||     |::.|.|.....:.: |.|..  |||.::.:. |||....|...:.
Mouse   453 PQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKA-PVVPSPVLQSPSDGLGMGAGPACPLPPLAG 516

  Fly   806 GQLLVIPTPSKQTTQHHRPGQPGQ-GVIIQQQQPAELHPQPGGGYIVSQPSPVAAASSSSSSSTV 869
            |:....|:| :|.......|.||. |.:          |.|   ..:.||.|
Mouse   517 GEAFPFPSP-EQGLALSGAGFPGMLGAL----------PLP---LSLGQPPP------------- 554

  Fly   870 ILNSGGAKLLHHQIITSQAGQINQATSGGSGNQPQTVLLNTLPNGGYIVQQQPQTQSPQQAEQIL 934
                  :..|.|.:.         ....|.|..|...||.  |.||   ...|......:...:|
Mouse   555 ------SPFLSHSLF---------GVLAGGGQPPPEPLLP--PPGG---PGPPSAPGEPEGPSLL 599

  Fly   935 --AMPQPPPAQTLIISSPDTKRRARKRKSSVCHTPPPSGSPAKIIS---PQISPSIPNQAPALLH 994
              ::..|||:..|                     ||||..|:.:::   |.::     ..|....
Mouse   600 VASLLSPPPSDLL---------------------PPPSAPPSNLLASFLPLLA-----LGPTAGD 638

  Fly   995 QQAAAAAAAAPQ---FQQQFQLSPGIQGIVVNKPNPP-QQPQTQQLLLQNGQILQQVNLIGQQLL 1055
            .:.:|..|..|.   |.....|.|.:        .|| ..|.|  |:..|..      |:...|.
Mouse   639 GEGSAEGAGGPNGEPFSGLGDLPPLL--------FPPLSAPPT--LIALNSA------LLAASLD 687

  Fly  1056 MPAGLVMGPDATLLQIQNMPATSLMT-----PQGPVMLRTPSPQNKPSFISP------SAGGQQY 1109
            .|:|....| ..|...|..|.||.:|     |....:.:.||...:|..:||      .||....
Mouse   688 PPSGTPPQP-CVLSAPQPGPPTSSVTTATTDPGASSLGKAPSNSGRPQLLSPLLSASLLAGDLSS 751

  Fly  1110 LVGANGQ----LSPIGQIYSTPMGL-VMPTGQQGGASFVQASPTTTTIQ-IQQQPAPQPTQISLQ 1168
            |..:.|.    |.|.|.:.|:.:|| ::|.|....|....:||....:| :||.|..||....|.
Mouse   752 LASSPGALPSLLQPPGPLLSSQLGLQLLPGGGAPPALSEASSPLACLLQSLQQIPPEQPDAPCLP 816

  Fly  1169 PAQATYMTETVMSRQGTAASPPDTTTCSPRSPE----RPSSHRS--SGSDMVQCVSSSEPDAAVS 1227
            |.......|...:|...:|..|...:..|..||    |.|..|.  .|..:......:.|.....
Mouse   817 PESPASALEPEPARPPLSALAPPHASPDPPVPELLTGRGSGKRGRRGGGGLRGINGETRPGRGRK 881

  Fly  1228 PQSTESRQSPSSTDCERSICKNNVFTQPSGIYKHSEPKIRRIHITSQTSAENGISLMQGQESPTT 1292
            |   .||:.|.     |...|   :....|.....|...||.|...    .|| .|.:|...|..
Mouse   882 P---GSRREPG-----RLALK---WGTRGGFNGQMERSPRRTHHWQ----HNG-ELAEGGAEPKD 930

  Fly  1293 TQLLSSVPTAQPTVEKTTVRTPTKRSRRPQRGAAR----AAPSASDK-------------SFPLP 1340
            ..|        |......::.|....|:.:||..|    |..|:|.:             :.|||
Mouse   931 PPL--------PGTHSEDLKVPPGIVRKSRRGRRRKYNPARNSSSSRQDVTLEPSPTTRAAVPLP 987

  Fly  1341 PRS 1343
            ||:
Mouse   988 PRA 990

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sba	NP_001262888.1	MBD	241..315	CDD:128673	32/83 (39%)
		PWWP_MBD5	1344..1441	CDD:438969	272/1238 (22%)
Mbd6	NP_149063.2	MBD	21..86	CDD:469618	28/64 (44%)
		Required for interaction with ASXL1/2/3. /evidence=ECO:0000250|UniProtKB:Q96DN6	59..70		8/10 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	123..222		27/142 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	241..302		14/107 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	334..619		83/373 (22%)
		PHA03247	<379..838	CDD:223021	127/559 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	631..659		5/32 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	684..736		14/52 (27%)
		PHA03247	<687..1005	CDD:223021	81/329 (25%)