DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sba and Mbd6

DIOPT Version :9

Sequence 1:	NP_001262888.1	Gene:	sba / 42824	FlyBaseID:	FBgn0016754	Length:	1606	Species:	Drosophila melanogaster
Sequence 2:	NP_149063.2	Gene:	Mbd6 / 110962	MGIID:	106378	Length:	1005	Species:	Mus musculus

Alignment Length:	1238	Identity:	272/1238 - (21%)
Similarity:	388/1238 - (31%)	Gaps:	376/1238 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 NGNINRKTATSYNGNLAP-------GWRRLTNNNEVAYISPSGKTLRTQFQIKDYLLTQGTCKCG 290
            ||: |..:|....|..|.       ||:|......|.||||||..|.:..|.:.|||:.||||||
Mouse     2 NGD-NASSAADRAGGPAATPVPIPIGWQRCVREGAVYYISPSGTELSSLEQTRSYLLSDGTCKCG 65

  Fly   291 LPCPLRPEYLFDFNAQVPNQPLKL---PTEASTATPTPCRHQRRFLESQQLQLPQQQQQQQHLQH 352
            |.|||....:|:|:...|..|...   |......|.. |.|:|:.:....|
Mouse    66 LECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKL-CNHRRKAVAMATL-------------- 115

  Fly   353 QQQQQQAVKDVSVDVAVSVSGPAAVSDVFSTLMTSTARTATMVTPTAATSPAQAATTTTHEMANK 417
                   .:.:....:.|..|..|...:|.|:...         |.:...|.:|..||
Mouse   116 -------YRSMETTCSHSSPGEGASPQMFHTVSPG---------PPSVRPPCRAPPTT------- 157

  Fly   418 DADCHKYGNNKLPATNRTATTPTPAPT---------------PPPQHPNGMPTSQALALGGVPVG 467
                        |......:.|...|:               |||:.|:.:|::.:.:...:|.|
Mouse   158 ------------PLNGGPGSIPQDPPSVPQAFPPLTGPAGLFPPPRLPDPVPSAGSSSPCFLPRG 210

  Fly   468 VHPKRPTGGHVIKQPASVLGPPCTPPLAVG--------GA---NTVIQQQQPLQQHPNFKDDPAG 521
            ..|          .||    ||  ||.|:.        ||   :.::.........|:....|
Mouse   211 NAP----------SPA----PP--PPPAISLNAPSYNWGASLRSNLVPSDLGSPPAPHASSSP-- 257

  Fly   522 YLQQQTALLHNSLGVGLDATKTAAGTSTARALPQEPIVHSSQQQQQQQQQQLQQQQQLQRQKIRR 586
              ...:.|.|.|                 .||...|:..|:.....
Mouse   258 --PSDSPLFHCS-----------------DALTSPPLPPSNNPPGP------------------- 284

  Fly   587 LSLFGKWETDPAPATNSQPTNGTRALQV------DAAAFARPQKPQVTCVTL--------VPPPQ 637
                   ...|.|||....::.|..|.:      .|.|...|..|.....:|        :|||
Mouse   285 -------PGPPGPATQPPVSSATMHLPLVLGSLGGAPAVEGPGAPPFLASSLLSAAAKAQLPPP- 341

  Fly   638 ESPVSSSAAETLEKRPEQVGAISTSHESPRQSLSSPT-----------DSVDSAKSTPSASPKPQ 691
                     .||:.|..:..|.|.:|.|||.|...|.           ....:.:.|...:|.|.
Mouse   342 ---------STLQGRRPRAQAPSAAHASPRPSQRRPRRPPTVLRLLEGGGPQTPRRTRPRAPAPV 397

  Fly   692 TQ-----VPMQPQLLQMRPHLQANLSAQTPVTVPAHVR---VMRQQQAQIIPGQRLPVASSSAAM 748
            .|     .|.||.|    |.:.:.|...||  .|:|..   .:....|.:.|    |.|.||.:.
Mouse   398 PQPFPLPEPSQPIL----PSVLSLLGLPTP--GPSHSDGSFNLLGSDAHLPP----PPALSSGSP 452

  Fly   749 ATMTRSIVTSTAGT-----STITGRPVATTLNNSNPTVAQ--LQSMANAMN-GAGGGGQLIMTSS 805
            ......|..|..||     |::.|.|.....:.: |.|..  |||.::.:. |||....|...:.
Mouse   453 PQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKA-PVVPSPVLQSPSDGLGMGAGPACPLPPLAG 516

  Fly   806 GQLLVIPTPSKQTTQHHRPGQPGQ-GVIIQQQQPAELHPQPGGGYIVSQPSPVAAASSSSSSSTV 869
            |:....|:| :|.......|.||. |.:          |.|   ..:.||.|
Mouse   517 GEAFPFPSP-EQGLALSGAGFPGMLGAL----------PLP---LSLGQPPP------------- 554

  Fly   870 ILNSGGAKLLHHQIITSQAGQINQATSGGSGNQPQTVLLNTLPNGGYIVQQQPQTQSPQQAEQIL 934
                  :..|.|.:.         ....|.|..|...||.  |.||   ...|......:...:|
Mouse   555 ------SPFLSHSLF---------GVLAGGGQPPPEPLLP--PPGG---PGPPSAPGEPEGPSLL 599

  Fly   935 --AMPQPPPAQTLIISSPDTKRRARKRKSSVCHTPPPSGSPAKIIS---PQISPSIPNQAPALLH 994
              ::..|||:..|                     ||||..|:.:::   |.::     ..|....
Mouse   600 VASLLSPPPSDLL---------------------PPPSAPPSNLLASFLPLLA-----LGPTAGD 638

  Fly   995 QQAAAAAAAAPQ---FQQQFQLSPGIQGIVVNKPNPP-QQPQTQQLLLQNGQILQQVNLIGQQLL 1055
            .:.:|..|..|.   |.....|.|.:        .|| ..|.|  |:..|..      |:...|.
Mouse   639 GEGSAEGAGGPNGEPFSGLGDLPPLL--------FPPLSAPPT--LIALNSA------LLAASLD 687

  Fly  1056 MPAGLVMGPDATLLQIQNMPATSLMT-----PQGPVMLRTPSPQNKPSFISP------SAGGQQY 1109
            .|:|....| ..|...|..|.||.:|     |....:.:.||...:|..:||      .||....
Mouse   688 PPSGTPPQP-CVLSAPQPGPPTSSVTTATTDPGASSLGKAPSNSGRPQLLSPLLSASLLAGDLSS 751

  Fly  1110 LVGANGQ----LSPIGQIYSTPMGL-VMPTGQQGGASFVQASPTTTTIQ-IQQQPAPQPTQISLQ 1168
            |..:.|.    |.|.|.:.|:.:|| ::|.|....|....:||....:| :||.|..||....|.
Mouse   752 LASSPGALPSLLQPPGPLLSSQLGLQLLPGGGAPPALSEASSPLACLLQSLQQIPPEQPDAPCLP 816

  Fly  1169 PAQATYMTETVMSRQGTAASPPDTTTCSPRSPE----RPSSHRS--SGSDMVQCVSSSEPDAAVS 1227
            |.......|...:|...:|..|...:..|..||    |.|..|.  .|..:......:.|.....
Mouse   817 PESPASALEPEPARPPLSALAPPHASPDPPVPELLTGRGSGKRGRRGGGGLRGINGETRPGRGRK 881

  Fly  1228 PQSTESRQSPSSTDCERSICKNNVFTQPSGIYKHSEPKIRRIHITSQTSAENGISLMQGQESPTT 1292
            |   .||:.|.     |...|   :....|.....|...||.|...    .|| .|.:|...|..
Mouse   882 P---GSRREPG-----RLALK---WGTRGGFNGQMERSPRRTHHWQ----HNG-ELAEGGAEPKD 930

  Fly  1293 TQLLSSVPTAQPTVEKTTVRTPTKRSRRPQRGAAR----AAPSASDK-------------SFPLP 1340
            ..|        |......::.|....|:.:||..|    |..|:|.:             :.|||
Mouse   931 PPL--------PGTHSEDLKVPPGIVRKSRRGRRRKYNPARNSSSSRQDVTLEPSPTTRAAVPLP 987

  Fly  1341 PRS 1343
            ||:
Mouse   988 PRA 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sba	NP_001262888.1	MBD	241..315	CDD:128673	32/83 (39%)
sba	NP_001262888.1	PWWP	1344..1440	CDD:295359	272/1238 (22%)
Mbd6	NP_149063.2	MBD	21..86	CDD:381808	28/64 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	123..222		27/142 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..302		14/107 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	334..619		83/373 (22%)
		PHA03247	<379..838	CDD:223021	127/559 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	631..659		5/32 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	684..736		14/52 (27%)
		PHA03247	<687..1005	CDD:223021	81/329 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850823
Domainoid	1	1.000	79	1.000	Domainoid score	I8732
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44331
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16112
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6504
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.060