DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sba and Mbd5

DIOPT Version :9

Sequence 1:	NP_001262888.1	Gene:	sba / 42824	FlyBaseID:	FBgn0016754	Length:	1606	Species:	Drosophila melanogaster
Sequence 2:	NP_084200.1	Gene:	Mbd5 / 109241	MGIID:	2138934	Length:	1728	Species:	Mus musculus

Alignment Length:	1862	Identity:	372/1862 - (19%)
Similarity:	567/1862 - (30%)	Gaps:	757/1862 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   246 GNLAP-----GWRRLTNNNEVAYISPSGKTLRTQFQIKDYLLTQGTCKCGLPCPLRPEYLFDFN- 304
            |.||.     ||:|..::|.|.||||||..|....|:|.||||.|||||||.|||....:|:|:
Mouse    14 GGLAAIQVPVGWQRRVDHNGVLYISPSGSLLSCLDQVKTYLLTDGTCKCGLECPLILPKVFNFDP 78

  Fly   305 ---------------------------------------AQVPNQPLKLPTEASTATP------- 323
                                                   |..|:..|..|...:.|||
Mouse    79 GAAVKQRTAEDVKADDDVTKLCIHKRKIIAVATLHQSMEAPHPSLVLTSPGGGTNATPVVPSRAA 143

  Fly   324 TP------------------CRHQRRFLESQ--------QLQLPQQQQQQQHLQHQQQQQQAVKD 362
            ||                  |::..:.:...        ...||..|||:.|..:.:|:
Mouse   144 TPRSVRNKSHEGITNSVMPECKNPFKLMTGSSNAMGRLYMQDLPGSQQQELHPVYPRQR------ 202

  Fly   363 VSVDVAVSVSGPAAVSDVFSTLMTSTARTATMVTPTAATSPAQAATTTTHEMANKDADCHKYGNN 427
                :..|..|..:........:.|.|.:.:.:....:.||......:.......:...|...|:
Mouse   203 ----LGSSEHGQKSPFRGSHGGLPSPASSGSQIYGDGSISPRTDPLGSPDVFTRNNPGFHGAPNS 263

  Fly   428 KLPATNRTATTPTPAPTPPPQHPNGMPTSQALALGG---VPVGVHPKRPTGGHVIKQPASVL--- 486
            .....|||..      :||....:|.|...:.|:.|   :|:.  |...|...|:|:|....
Mouse   264 SPIHLNRTPL------SPPSVMLHGSPVQSSCAMAGRTNIPLS--PTLTTKSPVMKKPMCNFSTN 320

  Fly   487 --------------GPPCTPPLAVGGANTVIQQQQPLQQHPNFKDDPAGYLQ-------QQTALL 530
                          |||..||      .:...|::||..    :.||.|.|.       .|..::
Mouse   321 MEIPRAMFHHKPPQGPPPPPP------PSCALQKKPLTS----EKDPLGILDPIPSKPVNQNPII 375

  Fly   531 ----------HNSLGVGLDATKTAAGTSTARALPQEPIVHSSQQQQQQQQQQLQQQQQLQRQKIR 585
                      |:.:.| ::.:...|.......||. |.|...........|::|..
Mouse   376 INPTSFHSNVHSQVPV-MNVSMPPAVVPLPSNLPL-PTVKPGHMNHGSHVQRIQHS--------- 429

  Fly   586 RLSLFGKWETDPAPATNSQPTNGTRALQVDAAAFARPQK-------------------PQVTCVT 631
                 ......|:|.|:.....||...:::|:    ||:                   ||.||..
Mouse   430 -----ASTSLSPSPVTSPVHMMGTGIGRIEAS----PQRSRSSSTSSDHGNFMMPPVGPQATCSG 485

  Fly   632 LVPPPQESPVSSSAAETLEKRPEQVGAISTSHESPRQSLSSPTD---SVDSAKSTPSA-----SP 688
            :..||: ||.|:..:    .||....:.||..:...|....|..   .:.:..:|||:     :|
Mouse   486 IKVPPR-SPRSTIGS----PRPSMPSSPSTKSDGHHQYKDIPNPLIAGMSNVLNTPSSAAFPTAP 545

  Fly   689 KPQTQVPMQPQLLQM------RPHLQANLSAQTPVTVPAHVRVMRQQQAQIIPGQRLPVASSSAA 747
            .....|..||.||.|      ..|..|:..|.:.::..|..::..|.:   :.|.....:::|.|
Mouse   546 AGNGSVKSQPGLLGMPLNQILNQHNAASFPASSLLSAAAKAQLANQNK---LAGNNSSSSNNSGA 607

  Fly   748 MATMTRSIVTSTAGTSTI-------------TG-------------------------RPVATTL 774
            :|:.     .:|.|.||:             ||                         :|..|.|
Mouse   608 VASS-----GNTEGHSTLNTMFPPTANMLLPTGEGQSGRAALRDKLMSQQKDSLRKRKQPPTTVL 667

  Fly   775 N-------------------------NSNP--TVAQ-LQSM--------ANAMNGAGGGGQLIMT 803
            :                         .|.|  :::| ||||        :|:..|.||....:..
Mouse   668 SLLRQSQMDSSAAPKPGPDLLRKHGQGSFPISSMSQLLQSMSCQSSHLSSNSTPGCGGSNTALPC 732

  Fly   804 SSGQLLVIPTPSKQTT----------------------------------QHHRPGQPGQ----- 829
            |:.| |..|.|:..:|                                  .||..|...|
Mouse   733 SANQ-LHFPDPNMNSTVLQNSLTQSIPLRGEAVHCHNANTNFVHSNSPVPNHHLAGLINQIQASG 796

  Fly   830 --GVIIQQQQPA--ELHPQPGGGYIVSQPSPVAAASSSSSSSTVILNSGGAKL--------LHHQ 882
              |::.|.....  .|||.|....|.:..:||...|..||.:.....:||:.|        .:|.
Mouse   797 NCGMLSQSGMALGNSLHPNPPQSRISTSSTPVIPNSIVSSYNQTSSEAGGSSLPSSIAIAGSNHP 861

  Fly   883 -------------IITSQAGQINQ---------------------ATSGGSGNQPQTV---LLNT 910
                         |:|:.||...|                     :.|..:.:.|..:   ||::
Mouse   862 AITKTTSVLQDGVIVTTAAGNPLQSQLPIGSDFPFVGQEHALHFPSNSTANNHLPHPLNPSLLSS 926

  Fly   911 LP-----NGGYIVQQ------QPQT---------------------------------------- 924
            ||     |..:::.|      ||..
Mouse   927 LPISLPVNQQHLLNQNLLNILQPSAGEGKSEINLHPLGFLNPNVNAALAFLSGDVDGQVLQPVHF 991

  Fly   925 -------QSPQQAEQILAMPQ--------------PPPAQTLIISSPD---TKRRARKRKSSVCH 965
                   |:..||..:|.:|.              |.|..|.:.:.||   :.:....|..::..
Mouse   992 QLLAALLQNQAQAAAMLPLPSFNLTISDLLQPQNTPLPLLTQMTAPPDRLPSNQSDNSRADTLLG 1056

  Fly   966 TP---PPSGS---------PA-------KIISPQISPSIPNQAPA--LLHQQAAAA--------- 1000
            :|   |.:||         ||       ..::||:...:.|.|.|  .:|.:.:.|
Mouse  1057 SPLGNPLAGSDTTFNPLLLPAVTGASGLMALNPQLLGGVLNSASANTAIHPEVSIATSSQATTTT 1121

  Fly  1001 -----AAAA----------------------------------------PQFQQQFQLSPGIQGI 1020
                 |.||                                        ||..... |..|:.|.
Mouse  1122 TTTSSAVAALTVSTLGGTAVVSMAETLLNISNNAGNPPGPAKLNSNSMVPQLLNPL-LGTGLLGD 1185

  Fly  1021 V--------------------VNKPNPPQQPQTQQLLLQNGQILQQVNLIGQQLL-MPAG----- 1059
            :                    .|:..||.| |.||.|||..|.||...  ||..: .||.
Mouse  1186 ISSINNSLNNHQLTHLQSLLNSNQMFPPNQ-QPQQHLLQGHQNLQAFQ--GQPTVPCPANNNPMA 1247

  Fly  1060 -------LVMGPDATLL--QIQNMPATSLMTPQGPVMLRTPSPQNKPSFISPSAGGQQYLVGANG 1115
                   :.|..||.||  :|...|..:.: |:.| .|..|..|:.|..:.|..
Mouse  1248 CLFQNFQVRMQGDAALLNKRISTQPGLTTL-PENP-NLALPHFQDTPCELQPRI----------- 1299

  Fly  1116 QLSPIGQIYSTPM--GLVMPTGQQGGAS-------FVQASP------TTTTIQIQQQPAPQPTQI 1165
               .:||    ||  ||||  |.||.||       .|.|:.      .||.:....|.:|.|...
Mouse  1300 ---DLGQ----PMKDGLVM--GGQGDASVDAIYKAVVDAASKGMQVVITTAVNSTTQISPIPALS 1355

  Fly  1166 SL--------QPAQATYMTETVMSRQGTAASPPDTTTCSPRSPERPSS----HRSSGSDMVQCVS 1218
            ::        .|...:.....|:..:.......|....:.|....|.:    ..||..|..:|..
Mouse  1356 AMSAFTASIGDPLNLSSAVSAVIHGRNMGGVDHDGRLRNARGARLPKNIDHGKNSSEGDGFECFK 1420

  Fly  1219 SSEPDAAVSPQSTESRQSPSSTDCERSICKNNVFTQPSGIYKHSEPKIRRIHITSQTSAENGIS- 1282
            |:  ....|.:..:..|||..   ||:..|...|....| :.||.|...|         .|.:|
Mouse  1421 SA--SCHTSRKQWDGEQSPRG---ERNRWKYEEFLDHPG-HIHSSPCHER---------PNNVST 1470

  Fly  1283 --LMQGQESPTT--------TQLLS----------SVPTAQPTVEKTTVRTPTKRSRRPQR---- 1323
              .:.|::.|..        .::|.          ::.:.:..:|.|..|.......||::
Mouse  1471 LPFLAGEQHPILLPPRNCQGDKILEENFRYNNYKRTMMSFKERLESTVERCTHINGNRPRQSRGF 1535

  Fly  1324 ----GAAR--------------------------------------AAPSASD-KSFP------- 1338
                |.|:                                      ..||.|| ||..
Mouse  1536 GELLGTAKQDLVLEGQSPGSSNSLESSLVKDYIHYNGDFNAKTINGCVPSPSDAKSISSEDDLRN 1600

  Fly  1339 -----------LPPRSFAIGELIWGPARGHPAWPGKIVKMPDGVCTPSQQFDHVWVQWFGGGGRS 1392
                       ..||:|.:|:|:||..:|..:||||.:: .|.|....||              |
Mouse  1601 PDSPSSHELIHYRPRTFNVGDLVWGQIKGLTSWPGKFIR-EDDVHNSCQQ--------------S 1650

  Fly  1393 TSE-LIPVNSLQSLSEGLEAHHKAQKDTRKSRKLNSQLERAIQEAMTELDNISASSTPAATSSSS 1456
            ..| .:....|::|:|||||:.:.:|.:|||.|||:.||.||.|||:|||.:            |
Mouse  1651 PEEGKVEPEKLKTLTEGLEAYSRVRKRSRKSGKLNNHLEAAIHEAMSELDKM------------S 1703

  Fly  1457 ATISAVPASAGPAVIGGQQQYQQQQQQQQQQQSPSSTNNKIN 1498
            .|:..:|                  |..:|.:.|.....||:
Mouse  1704 GTVHQIP------------------QGDRQMRPPKPKRRKIS 1727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sba	NP_001262888.1	MBD	241..315	CDD:128673	36/113 (32%)
sba	NP_001262888.1	PWWP	1344..1440	CDD:295359	37/96 (39%)
Mbd5	NP_084200.1	MBD	21..79	CDD:412167	30/57 (53%)
Mbd5	NP_084200.1	PWWP	1617..1694	CDD:413370	34/91 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850822
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28KVR
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4015
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44331
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR16112
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6504
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.010