DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-1 and SPT7

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_009637.1	Gene:	SPT7 / 852373	SGDID:	S000000285	Length:	1332	Species:	Saccharomyces cerevisiae

Alignment Length:	482	Identity:	91/482 - (18%)
Similarity:	171/482 - (35%)	Gaps:	135/482 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PDYHAVVKHPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVYQAGKLLMEAFYM 139
            |:||.::|..|||:|:.|:|.:..|....|.::|..||:.|||.||.:.|...:...:.|:...:
Yeast   476 PNYHQIIKKSMDLNTVLKKLKSFQYDSKQEFVDDIMLIWKNCLTYNSDPSHFLRGHAIAMQKKSL 540

  Fly   140 RM----ESIDLSTEVELKPKSEKRKRKATESLDQASTSFSAPRASNNYSRQWLSSSSSWLCPPPM 200
            ::    .:|.:....:|:.:.|..::.....||:......:.|...|.....|:..:
Yeast   541 QLIRMIPNITIRNRADLEKEIEDMEKDKDYELDEEEEVAGSGRKGLNMGAHMLAKEN-------- 597

  Fly   201 PGGVSSFNPSFRNFVGPSLIPSFMPDSLVNPMQSMHPMSSMMNPIFKNNWETNEAMDPPPSEPIS 265
             |.||..:.|                                 ...|:...||:
Yeast   598 -GKVSEKDSS---------------------------------KTVKDEAPTND----------- 617

  Fly   266 YRPLDSLAAPLPSPPMEPMTLPWPTPAPVESPASSPPPAPNPPIIICYKSLDRMIEKSHSDHLLK 330
                |.|.:.:|....|.           :..|||        .:..::::::...|.:..:..:
Yeast   618 ----DKLTSVIPEGEKEK-----------DKTASS--------TVTVHENVNKNEIKENGKNEEQ 659

  Fly   331 SMVKRKRK-------------------QVTWAFNQADYWRRYSQNPDYDHDREEKL---DWKILQ 373
            .||:...|                   |...|.|:........:..|.|.|.:|.:   ...:|:
Yeast   660 DMVEESSKTEDSSKDADAAKKDTEDGLQDKTAENKEAGENNEEEEDDDDEDEDEDMVDSQSYLLE 724

  Fly   374 ERLDSDNFE--SFDGFVSSVR--------KMFQNALRCFPEDGLVK--VSVKKTNEIF-----EK 421
            :..|.|:.|  .:....:.||        :.|:|.......:..:|  ..:|:.:::|     :|
Yeast   725 KDDDRDDLEISVWKTVTAKVRAEICLKRTEYFKNGKLNSDSEAFLKNPQRMKRFDQLFLEYKEQK 789

  Fly   422 RLPKYRELIA--TAKEKGRQLVASREQD----FRDSQNLLIKQENANKNFKGWVPKPFIIK-TES 479
            .|..||:.|.  :..:.|...|..:|.|    |.:..:|     |.|:.|:   .:|..|: .::
Yeast   790 ALESYRQKIEQNSIMKNGFGTVLKQEDDDQLQFHNDHSL-----NGNEAFE---KQPNDIELDDT 846

  Fly   480 LFVQEQRVYKMEPQDVQEFSPGTEPLD 506
            .|:||..:....|..|.| ...|:.||
Yeast   847 RFLQEYDISNAIPDIVYE-GVNTKTLD 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	22/71 (31%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371	22/133 (17%)
SPT7	NP_009637.1	COG5076	282..680	CDD:227408	48/279 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860