DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-1 and BDF1

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_013503.1	Gene:	BDF1 / 851115	SGDID:	S000004391	Length:	686	Species:	Saccharomyces cerevisiae

Alignment Length:	506	Identity:	99/506 - (19%)
Similarity:	180/506 - (35%)	Gaps:	141/506 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ELQSNSNQPPPRNEPYLQPVNGIVQPPVIPPP-----NRP------GRRTNILEELKSVLNCLWR 56
            :|..||.|..|...|        .:|...|||     |.|      .::.:.|..:|:|.    |
Yeast   114 DLDENSKQELPMEVP--------KEPAPAPPPEPDMNNLPQNPIPKHQQKHALLAIKAVK----R 166

  Fly    57 NRFSYHFRHPVDSVSLGVPDYHAVVKHPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNL 121
            .:.:..|..|||.|.|.:|.|...:|.|||||||.::|:...|....:..|||.|:.:|.:.:|.
Yeast   167 LKDARPFLQPVDPVKLDIPFYFNYIKRPMDLSTIERKLNVGAYEVPEQITEDFNLMVNNSIKFNG 231

  Fly   122 EGSPVYQAGKLLMEAFYMRMESIDLSTEVELKPKSEKRKRKATES-----LDQASTSFSAPRASN 181
            ..:.:.|..:.:..:|...|.::...   :..|...|.:|.:.:.     :.:|.|....|:.:
Yeast   232 PNAGISQMARNIQASFEKHMLNMPAK---DAPPVIAKGRRSSAQEDAPIVIRRAQTHNGRPKRT- 292

  Fly   182 NYSRQWLSSSSSWLCPPPMPGGVSSFNPSFRNFVGPSLIPSFMPDSLVNPMQSMHPMSSMMNPIF 246
                         :.||....                          :.|.:|..|.|..:....
Yeast   293 -------------IHPPKSKD--------------------------IYPYESKKPKSKRLQQAM 318

  Fly   247 KNNWETNEAMDPPPSEPISY---RPLDSLAAPLPS------PPMEPMTL-----PWPTPAPVESP 297
            |......:.:........:|   .|:|.::..||:      .||:..|:     .|.
Yeast   319 KFCQSVLKELMAKKHASYNYPFLEPVDPVSMNLPTYFDYVKEPMDLGTIAKKLNDWQ-------- 375

  Fly   298 ASSPPPAPNPPIIICYKSLD------RMIEKS----HSDHLLKSMVKRKRKQVTWAFNQADYWRR 352
                           |::::      |::.|:    :.|..:.:|:..:.::|   ||..  |..
Yeast   376 ---------------YQTMEDFERDVRLVFKNCYTFNPDGTIVNMMGHRLEEV---FNSK--WAD 420

  Fly   353 YSQNPDYDHDREEKLDWKILQERLDSDNFESFDGFVSSVRKMFQNALRCFPEDGLVKVSVK---- 413
            .....|||.|.:.:...       |.|::||..........:..|....:.|:.|.::.|:
Yeast   421 RPNLDDYDSDEDSRTQG-------DYDDYESEYSESDIDETIITNPAIQYLEEQLARMKVELQQL 478

  Fly   414 KTNEIFEKRLPKYRELIATAKEKGRQLVASREQDFRDSQNLLIKQENANKN 464
            |..|:  :::.|.|.|...:|::|:     |.:....|:|...|.....||
Yeast   479 KKQEL--EKIRKERRLARGSKKRGK-----RSKGRSGSKNASSKGRRDKKN 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	31/103 (30%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371	19/98 (19%)
BDF1	NP_013503.1	COG5076	1..373	CDD:227408	64/313 (20%)
		Bromodomain	<339..417	CDD:413371	16/103 (16%)
		PTZ00108	<386..647	CDD:240271	33/156 (21%)
		BET	527..589	CDD:407211
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345970
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	1	1.000	-	-		mtm9193
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.700