DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-1 and BRDT

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001229735.2	Gene:	BRDT / 676	HGNCID:	1105	Length:	951	Species:	Homo sapiens

Alignment Length:	434	Identity:	112/434 - (25%)
Similarity:	178/434 - (41%)	Gaps:	98/434 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IVQPPVIPP----PNRPGRRTNILEEL-KSVLNCLWRNRFSYHFRHPVDSVSLGVPDYHAVVKHP 84
            ||.||  ||    ..:.||.||.|:.| |.||..||::.||:.|:.|||:|.|.:|||:.::|:|
Human    11 IVNPP--PPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNP 73

  Fly    85 MDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVYQAGKLLMEAFYMRMESIDLSTE 149
            |||:||:|||.||||.:|||.:|||..:|.||.|||..|..:....:.|.:.|..::..:....:
Human    74 MDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQ 138

  Fly   150 -VELKPKSEKRKRKATESLDQASTS--FSAPRASNNYSRQWLSSSSSWLCPPPMPGGVSSFNPSF 211
             |.:|.:.:|.|...|:.....|::  .|:|.|:....:|
Human   139 VVGVKERIKKGKAGGTQQNIAVSSAKEKSSPSATEKVFKQ------------------------- 178

  Fly   212 RNFVGPSLIPSFMPDSLVNPMQ-----SMHPMSSMMNPIFKNNWETNEAMDPPPSEPISYRPLDS 271
                  ..|||..|.:.::|:.     |::..|.....:.|......:...|..|
Human   179 ------QEIPSVFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATS---------- 227

  Fly   272 LAAPLPSPPMEPMTLPWPTPAPVESPASSPPPAPNPP------------IIICYKSLDRMIEKSH 324
              |...|...        :|...|...:.||...|.|            ::...|..:::   .|
Human   228 --AVKASSEF--------SPTFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQL---RH 279

  Fly   325 SDHLLKSMVKRKRKQVTWAF-NQADY-------WRRYSQNPDYDHDREEKLDWKILQERLDSDNF 381
            ...:||.|:.:|.....|.| |..|.       :....:||         :|...::|::|:..:
Human   280 CSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNP---------MDLGTIKEKMDNQEY 335

  Fly   382 ESFDGFVSSVRKMFQNALRCFPEDGLVKVSVKKTNEIFEKRLPK 425
            :....|.:.||.||.|..:..|.|..|....:...::||....|
Human   336 KDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSK 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	50/104 (48%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371	24/102 (24%)
BRDT	NP_001229735.2	Bromo_Brdt_I_like	27..133	CDD:99929	50/105 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..232		4/37 (11%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:22971749	213..224		1/10 (10%)
		Bromo_Brdt_II_like	276..377	CDD:99930	25/112 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..424
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..515
		BET	513..575	CDD:293640
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..702
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..928
		BRD4_CDT	909..951	CDD:293710
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4344
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.820