DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbrd-1 and Brd3

DIOPT Version :9

Sequence 1:	NP_001369030.1	Gene:	tbrd-1 / 42823	FlyBaseID:	FBgn0039124	Length:	513	Species:	Drosophila melanogaster
Sequence 2:	NP_001107046.1	Gene:	Brd3 / 67382	MGIID:	1914632	Length:	743	Species:	Mus musculus

Alignment Length:	515	Identity:	136/515 - (26%)
Similarity:	211/515 - (40%)	Gaps:	130/515 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 PPPRNEPYLQPVNGIVQPPVIPPPNRPGRRTNILEELKS-VLNCLWRNRFSYHFRHPVDSVSLGV 74
            |.|.|.|          ||.:..|::|||:||.|:.::: |:..||:::|::.|..|||::.|.:
Mouse    15 PGPVNPP----------PPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNL 69

  Fly    75 PDYHAVVKHPMDLSTIRKRLHNKYYWQASEALEDFKLIFDNCLLYNLEGSPVYQAGKLLMEAFYM 139
            ||||.::|:|||:.||:|||.|.|||.|||.::||..:|.||.:||.....:....:.|.:.|..
Mouse    70 PDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQ 134

  Fly   140 RMESIDLSTEVELKPKSEKRK-RKATESLDQASTSFSAPRASNNYSRQWLSSSSSWLCPPPMPGG 203
            ::..:. ..||||.|.:.|.| ||            .|..|.|..|:|              ...
Mouse   135 KVAQMP-QEEVELLPPAPKGKGRK------------PAAGAQNAGSQQ--------------VAA 172

  Fly   204 VSSFNPS--FRNFVGPSLIPSFMPDSLVNPMQSMHPMSSMMNPIFKNNWETNEAMDPPPSEPISY 266
            |||.:|:  |:|      ||         |..|..|:.: ..|:............|||:.|
Mouse   173 VSSVSPATPFQN------IP---------PTVSQTPVIA-ATPVPTITANVTSVPVPPPAAP--- 218

  Fly   267 RPLDSLAAPLPSPPMEPMTLPWP------------------TPAPVESPASSPPPAPNP------ 307
                    |.|:.|:.|:..|.|                  |.|...|.:.||||...|
Mouse   219 --------PPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSEPKQAKVV 275

  Fly   308 --------PIIICYKSLD------------RMIEK-SHSDHLLKSMVKRKRKQVTWAFNQ---AD 348
                    ||....|.|:            ::.|. .|.|.:|:.|:.:|.....|.|.:   |:
Mouse   276 ARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRHCDSILREMLSKKHAAYAWPFYKPVDAE 340

  Fly   349 YWRRYSQNPDYDHDREEKLDWKILQERLDSDNFESFDGFVSSVRKMFQNALRCFPEDGLVKVSVK 413
            ....:    ||....:..:|...::.::||..:....||.:.:|.||.|..:..|.|..|....:
Mouse   341 ALELH----DYHDIIKHPMDLSTVKRKMDSREYPDAQGFAADIRLMFSNCYKYNPPDHEVVAMAR 401

  Fly   414 KTNEIFEKRLPKYRE----------LIATAKEKGRQLVASREQDFRDSQNLLIKQENANK 463
            |..::||.|..|..:          ..|....||.:...|.|:...||.:...::|.|.:
Mouse   402 KLQDVFEMRFAKMPDEPMEAPALPAPTAPIVSKGAESSRSSEESSSDSGSSDSEEERATR 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbrd-1	NP_001369030.1	Bromodomain	39..143	CDD:413371	42/104 (40%)
tbrd-1	NP_001369030.1	Bromodomain	328..423	CDD:413371	23/97 (24%)
Brd3	NP_001107046.1	Bromo_Brdt_I_like	33..139	CDD:99929	42/105 (40%)
		Bromo_Brdt_II_like	310..411	CDD:99930	25/104 (24%)
		BET	589..653	CDD:374956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842378
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	153	1.000	Inparanoid score	I4316
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000322
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100249
Panther	1	1.100	-	-	O	PTHR22880
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.750